Dual-pathological cascade delivery of apoptotic vesicles for targeted therapy in intervertebral disc degeneration

Dual-pathological cascade delivery of apoptotic vesicles for targeted therapy in intervertebral disc degeneration

Achieving effective drug delivery and therapeutic efficacy poses significant challenges in intervertebral disc degeneration (IDD). Here, we developed a dual-pathological cascade delivery system utilizing therapeutic mesenchymal stem cell-derived apoptotic vesicles (ApoVs). These vesicles are enginee...

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Bibliographic Details
Main Authors: Wei Chen, Tianyuan Zhao, Yiming Ren, Wenzhe Huang, Jiyuan Xia, Zhenxin Hu, Libo Chen, Hao Li, Qi Zhang, Han Wang, Penglei Cui, Quanyi Guo, Da He
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Materials Today Bio
Subjects:
Apoptotic vesicles
Aptamer
Hydrogel
Cellular senescence
Intervertebral disc degeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425007707
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