Microwave-enhanced additive-free C–H amination of benzoxazoles catalysed by supported copper

Microwave-enhanced additive-free C–H amination of benzoxazoles catalysed by supported copper

The C2-amination of benzoxazole offers wide-ranging potential for substrate expansion and the functionalisation of bioactive compounds. This study presents a green and efficient C–H amination, catalysed by CuCl and CuCl2, in acetonitrile without acidic, basic or oxidant additives that is accelerated...

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Bibliographic Details
Main Authors: Andrei Paraschiv, Valentina Maruzzo, Filippo Pettazzi, Stefano Magliocco, Paolo Inaudi, Daria Brambilla, Gloria Berlier, Giancarlo Cravotto, Katia Martina
Format: Article
Language:English
Published: Beilstein-Institut 2025-07-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
aerobic oxidation
copper
grafted silica
heterogeneous catalysis
microwave
Online Access:https://doi.org/10.3762/bjoc.21.108
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