Remodeling of Embryo Architecture in Response to Vanadium and Increased Temperatures: From Morphometric to Molecular Changes
The study of ecotoxicity induced by vanadium (V) represents an area of increasing interest due to the growing use of V in both the industrial and pharmaceutical areas. This leads to its introduction into water environments, marking a developing problem, especially since rising global temperatures ap...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-02-01
|
| Series: | Journal of Xenobiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2039-4713/15/1/22 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850080915470942208 |
|---|---|
| author | Roberto Chiarelli Chiara Martino Rosaria Scudiero Alessio Terenzi Fabiana Geraci |
| author_facet | Roberto Chiarelli Chiara Martino Rosaria Scudiero Alessio Terenzi Fabiana Geraci |
| author_sort | Roberto Chiarelli |
| collection | DOAJ |
| description | The study of ecotoxicity induced by vanadium (V) represents an area of increasing interest due to the growing use of V in both the industrial and pharmaceutical areas. This leads to its introduction into water environments, marking a developing problem, especially since rising global temperatures appear to intensify its toxic properties. Cytotoxicological approaches carried out on whole marine embryos represent a valid research tool since they grow directly in contact with the pollutants and are equipped with highly responsive cells to stressors. Here, we discuss the detrimental impact on <i>Paracentrotus lividus</i> sea urchin embryos resulting from the combination of V and higher temperatures, reflecting the effects of climate variation. The results demonstrate the remodeling of embryonic architecture at the morphometric level, revealing developmental delays and anomalies. These malformations involve variations in the total skeletal mass due to the almost total absence of the skeleton, with the exception of small calcareous aggregates. Furthermore, both a modulation in total tissue remodeling enzymatic activities and a variation in the amount of three MMP-like gelatinases (MMP-2, -9, and -14) were observed. This research demonstrates that climate change significantly increases the harmful effects of V, emphasizing the necessity for comprehensive toxicity assessments in environmental evaluations. |
| format | Article |
| id | doaj-art-e66c61b2d44f49ef8bf09d2808ac7c59 |
| institution | DOAJ |
| issn | 2039-4705 2039-4713 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Xenobiotics |
| spelling | doaj-art-e66c61b2d44f49ef8bf09d2808ac7c592025-08-20T02:44:50ZengMDPI AGJournal of Xenobiotics2039-47052039-47132025-02-011512210.3390/jox15010022Remodeling of Embryo Architecture in Response to Vanadium and Increased Temperatures: From Morphometric to Molecular ChangesRoberto Chiarelli0Chiara Martino1Rosaria Scudiero2Alessio Terenzi3Fabiana Geraci4Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, 90128 Palermo, ItalyDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, 90128 Palermo, ItalyDepartment of Biology, University Federico II, 80126 Napoli, ItalyDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, 90128 Palermo, ItalyDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, 90128 Palermo, ItalyThe study of ecotoxicity induced by vanadium (V) represents an area of increasing interest due to the growing use of V in both the industrial and pharmaceutical areas. This leads to its introduction into water environments, marking a developing problem, especially since rising global temperatures appear to intensify its toxic properties. Cytotoxicological approaches carried out on whole marine embryos represent a valid research tool since they grow directly in contact with the pollutants and are equipped with highly responsive cells to stressors. Here, we discuss the detrimental impact on <i>Paracentrotus lividus</i> sea urchin embryos resulting from the combination of V and higher temperatures, reflecting the effects of climate variation. The results demonstrate the remodeling of embryonic architecture at the morphometric level, revealing developmental delays and anomalies. These malformations involve variations in the total skeletal mass due to the almost total absence of the skeleton, with the exception of small calcareous aggregates. Furthermore, both a modulation in total tissue remodeling enzymatic activities and a variation in the amount of three MMP-like gelatinases (MMP-2, -9, and -14) were observed. This research demonstrates that climate change significantly increases the harmful effects of V, emphasizing the necessity for comprehensive toxicity assessments in environmental evaluations.https://www.mdpi.com/2039-4713/15/1/22embryo cytotoxicityskeletongelatinasesmetalloproteinasesglobal warmingclimate change |
| spellingShingle | Roberto Chiarelli Chiara Martino Rosaria Scudiero Alessio Terenzi Fabiana Geraci Remodeling of Embryo Architecture in Response to Vanadium and Increased Temperatures: From Morphometric to Molecular Changes Journal of Xenobiotics embryo cytotoxicity skeleton gelatinases metalloproteinases global warming climate change |
| title | Remodeling of Embryo Architecture in Response to Vanadium and Increased Temperatures: From Morphometric to Molecular Changes |
| title_full | Remodeling of Embryo Architecture in Response to Vanadium and Increased Temperatures: From Morphometric to Molecular Changes |
| title_fullStr | Remodeling of Embryo Architecture in Response to Vanadium and Increased Temperatures: From Morphometric to Molecular Changes |
| title_full_unstemmed | Remodeling of Embryo Architecture in Response to Vanadium and Increased Temperatures: From Morphometric to Molecular Changes |
| title_short | Remodeling of Embryo Architecture in Response to Vanadium and Increased Temperatures: From Morphometric to Molecular Changes |
| title_sort | remodeling of embryo architecture in response to vanadium and increased temperatures from morphometric to molecular changes |
| topic | embryo cytotoxicity skeleton gelatinases metalloproteinases global warming climate change |
| url | https://www.mdpi.com/2039-4713/15/1/22 |
| work_keys_str_mv | AT robertochiarelli remodelingofembryoarchitectureinresponsetovanadiumandincreasedtemperaturesfrommorphometrictomolecularchanges AT chiaramartino remodelingofembryoarchitectureinresponsetovanadiumandincreasedtemperaturesfrommorphometrictomolecularchanges AT rosariascudiero remodelingofembryoarchitectureinresponsetovanadiumandincreasedtemperaturesfrommorphometrictomolecularchanges AT alessioterenzi remodelingofembryoarchitectureinresponsetovanadiumandincreasedtemperaturesfrommorphometrictomolecularchanges AT fabianageraci remodelingofembryoarchitectureinresponsetovanadiumandincreasedtemperaturesfrommorphometrictomolecularchanges |