Clinical and Translational Considerations for Understanding Depression and Anxiety in Patients with Inflammatory Bowel Disease
Depression and anxiety are comorbidities of inflammatory bowel disease (IBD). Though previous studies have proposed a relationship between anxiety, depression, and IBD, causality and directionality are largely unknown. Current and future research in these areas is aimed at exploring the biological u...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/6689443 |
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| _version_ | 1850168076427853824 |
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| author | Ashley M. Sidebottom Tina G. Rodriguez Jordan E. Karpin David T. Rubin |
| author_facet | Ashley M. Sidebottom Tina G. Rodriguez Jordan E. Karpin David T. Rubin |
| author_sort | Ashley M. Sidebottom |
| collection | DOAJ |
| description | Depression and anxiety are comorbidities of inflammatory bowel disease (IBD). Though previous studies have proposed a relationship between anxiety, depression, and IBD, causality and directionality are largely unknown. Current and future research in these areas is aimed at exploring the biological underpinnings of this relationship, specifically pertaining to small molecule metabolism, such as tryptophan. Tryptophan is acquired through the diet and is the precursor to several vital bioactive metabolites including the hormone melatonin, the neurotransmitter serotonin, and vitamin B3. In this review, we discuss previous findings relating mental health comorbidities with IBD and underline ongoing research of tryptophan catabolite analysis. |
| format | Article |
| id | doaj-art-e668bd09d13c46ac8d9fb926546c23a9 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-e668bd09d13c46ac8d9fb926546c23a92025-08-20T02:21:04ZengWileyGastroenterology Research and Practice1687-61211687-630X2021-01-01202110.1155/2021/66894436689443Clinical and Translational Considerations for Understanding Depression and Anxiety in Patients with Inflammatory Bowel DiseaseAshley M. Sidebottom0Tina G. Rodriguez1Jordan E. Karpin2David T. Rubin3Department of Medicine, University of Chicago, Chicago, IL, USADepartment of Medicine, University of Chicago, Chicago, IL, USADepartment of Medicine, University of Chicago, Chicago, IL, USADepartment of Medicine, University of Chicago, Chicago, IL, USADepression and anxiety are comorbidities of inflammatory bowel disease (IBD). Though previous studies have proposed a relationship between anxiety, depression, and IBD, causality and directionality are largely unknown. Current and future research in these areas is aimed at exploring the biological underpinnings of this relationship, specifically pertaining to small molecule metabolism, such as tryptophan. Tryptophan is acquired through the diet and is the precursor to several vital bioactive metabolites including the hormone melatonin, the neurotransmitter serotonin, and vitamin B3. In this review, we discuss previous findings relating mental health comorbidities with IBD and underline ongoing research of tryptophan catabolite analysis.http://dx.doi.org/10.1155/2021/6689443 |
| spellingShingle | Ashley M. Sidebottom Tina G. Rodriguez Jordan E. Karpin David T. Rubin Clinical and Translational Considerations for Understanding Depression and Anxiety in Patients with Inflammatory Bowel Disease Gastroenterology Research and Practice |
| title | Clinical and Translational Considerations for Understanding Depression and Anxiety in Patients with Inflammatory Bowel Disease |
| title_full | Clinical and Translational Considerations for Understanding Depression and Anxiety in Patients with Inflammatory Bowel Disease |
| title_fullStr | Clinical and Translational Considerations for Understanding Depression and Anxiety in Patients with Inflammatory Bowel Disease |
| title_full_unstemmed | Clinical and Translational Considerations for Understanding Depression and Anxiety in Patients with Inflammatory Bowel Disease |
| title_short | Clinical and Translational Considerations for Understanding Depression and Anxiety in Patients with Inflammatory Bowel Disease |
| title_sort | clinical and translational considerations for understanding depression and anxiety in patients with inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2021/6689443 |
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