Multifunctional biosynthesized magnetosome for multimodal imaging and combined therapy of tumor
The large recruitment of tumor-associated macrophages and low exposure of tumor-associated antigens in tumor microenvironment have severely suppress the efficacy of anti-tumor immunotherapy. Herein, biosynthesized magnetosome (Mag) from bacteria was loaded with photothermal/photodynamic agent/near i...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004903 |
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| author | Xiaoqing Han Xingbo Wang Jiao Yan Panpan Song Yanjing Wang Yaqing Kang Abdur Rauf Haiyuan Zhang |
| author_facet | Xiaoqing Han Xingbo Wang Jiao Yan Panpan Song Yanjing Wang Yaqing Kang Abdur Rauf Haiyuan Zhang |
| author_sort | Xiaoqing Han |
| collection | DOAJ |
| description | The large recruitment of tumor-associated macrophages and low exposure of tumor-associated antigens in tumor microenvironment have severely suppress the efficacy of anti-tumor immunotherapy. Herein, biosynthesized magnetosome (Mag) from bacteria was loaded with photothermal/photodynamic agent/near infrared (NIR) fluorescence dye (IR780) and further modified with lipid-PEG-c(RGDyK) through biomembrane, forming IMagRGD for fluorescence imaging, magnetic resonance imaging, immunotherapy and photodynamic/photothermal therapy. After intravenous injection into B16F10 tumor-bearing mice, IMagRGD could efficiently accumulate in tumor tissues based on near infrared (NIR) fluorescence and magnetic resonance dual-modality imaging, and repolarize tumor-associated macrophages (TAMs) from M2 phenotype to M1 phenotype, significantly improving the effect of tumor immunotherapy. Moreover, photothermal and photodynamic effect of IR780 could kill tumor cells and elicit immunogenic cell death to mediate anti-tumor immunity, promoting dendritic cells (DCs) maturation and then activating specific effector T cells to further eliminate tumor cells. This study provides a new approach for reversing the activity of tumor immunosuppressive microenvironment and strengthening the efficiency of tumor photoimmunotherapy. |
| format | Article |
| id | doaj-art-e6689478387a452ea03f74b9597ba707 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-e6689478387a452ea03f74b9597ba7072025-01-17T04:52:11ZengElsevierMaterials Today Bio2590-00642025-02-0130101429Multifunctional biosynthesized magnetosome for multimodal imaging and combined therapy of tumorXiaoqing Han0Xingbo Wang1Jiao Yan2Panpan Song3Yanjing Wang4Yaqing Kang5Abdur Rauf6Haiyuan Zhang7Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, 130024, China; Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, ChinaSchool of Biomedical Engineering & The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, ChinaSchool of Biomedical Engineering & The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, ChinaSchool of Biomedical Engineering & The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, ChinaSchool of Biomedical Engineering & The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, ChinaSchool of Biomedical Engineering & The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, ChinaDepartment of Chemistry, University of Swabi, Ambar, 23430, PakistanLaboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; School of Biomedical Engineering & The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China; Corresponding author. Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Biomedical Engineering & The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China.zhangh@ciac.ac.cnThe large recruitment of tumor-associated macrophages and low exposure of tumor-associated antigens in tumor microenvironment have severely suppress the efficacy of anti-tumor immunotherapy. Herein, biosynthesized magnetosome (Mag) from bacteria was loaded with photothermal/photodynamic agent/near infrared (NIR) fluorescence dye (IR780) and further modified with lipid-PEG-c(RGDyK) through biomembrane, forming IMagRGD for fluorescence imaging, magnetic resonance imaging, immunotherapy and photodynamic/photothermal therapy. After intravenous injection into B16F10 tumor-bearing mice, IMagRGD could efficiently accumulate in tumor tissues based on near infrared (NIR) fluorescence and magnetic resonance dual-modality imaging, and repolarize tumor-associated macrophages (TAMs) from M2 phenotype to M1 phenotype, significantly improving the effect of tumor immunotherapy. Moreover, photothermal and photodynamic effect of IR780 could kill tumor cells and elicit immunogenic cell death to mediate anti-tumor immunity, promoting dendritic cells (DCs) maturation and then activating specific effector T cells to further eliminate tumor cells. This study provides a new approach for reversing the activity of tumor immunosuppressive microenvironment and strengthening the efficiency of tumor photoimmunotherapy.http://www.sciencedirect.com/science/article/pii/S2590006424004903MagnetosomeTumor-associated macrophagesPhotoimmunotherapyRepolarization |
| spellingShingle | Xiaoqing Han Xingbo Wang Jiao Yan Panpan Song Yanjing Wang Yaqing Kang Abdur Rauf Haiyuan Zhang Multifunctional biosynthesized magnetosome for multimodal imaging and combined therapy of tumor Materials Today Bio Magnetosome Tumor-associated macrophages Photoimmunotherapy Repolarization |
| title | Multifunctional biosynthesized magnetosome for multimodal imaging and combined therapy of tumor |
| title_full | Multifunctional biosynthesized magnetosome for multimodal imaging and combined therapy of tumor |
| title_fullStr | Multifunctional biosynthesized magnetosome for multimodal imaging and combined therapy of tumor |
| title_full_unstemmed | Multifunctional biosynthesized magnetosome for multimodal imaging and combined therapy of tumor |
| title_short | Multifunctional biosynthesized magnetosome for multimodal imaging and combined therapy of tumor |
| title_sort | multifunctional biosynthesized magnetosome for multimodal imaging and combined therapy of tumor |
| topic | Magnetosome Tumor-associated macrophages Photoimmunotherapy Repolarization |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004903 |
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