Low-intensity ultrasound lysis of amyloid microclots in a lab-on-chip model

Low-intensity ultrasound lysis of amyloid microclots in a lab-on-chip model

Amyloid fibrin(ogen) microclots are misfolded protein aggregates with β-sheet structures that have been associated with Long COVID and numerous thrombo-inflammatory diseases. These microclots persist in circulation and obstruct microvasculature, impair oxygen transport and promote chronic inflammati...

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Bibliographic Details
Main Authors: Reza Rasouli, Brad Hartl, Soren D. Konecky
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
microclots
ultrasound
fibrinolysis
long COVID
lab on a chip
LIFU
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1604447/full
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