The Corrective Effect of Fucoidan, a Sulfated Polysaccharide Extracted from Brown Algae Fucus evanescens, in the Formation of a Specific Immune Response Against Seasonal Influenza Viruses in the Elderly
The article establishes the particularities of immune system dysfunction in the elderly during formation of a specific immune response to vaccination with a seasonal influenza vaccine depending on the level of seroconversion. The corrective effect of fucoidan — a sulfated polysaccharide extracted fr...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-06-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/718 |
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| author | T. S. Zaporozhets S. P. Kryzhanovsky E. V. Persianova T. A. Kuznetsova T. P. Smolina A. K. Gazha N. M. Shevchenko S. P. Ermakova T. N. Zvyagintseva N. N. Besednova |
| author_facet | T. S. Zaporozhets S. P. Kryzhanovsky E. V. Persianova T. A. Kuznetsova T. P. Smolina A. K. Gazha N. M. Shevchenko S. P. Ermakova T. N. Zvyagintseva N. N. Besednova |
| author_sort | T. S. Zaporozhets |
| collection | DOAJ |
| description | The article establishes the particularities of immune system dysfunction in the elderly during formation of a specific immune response to vaccination with a seasonal influenza vaccine depending on the level of seroconversion. The corrective effect of fucoidan — a sulfated polysaccharide extracted from brown algae Fucus evanescens — was shown in the formation of a specific immune response, accompanied by an increase in the expression of the activation molecules CD69 and CD86 on monocytes, a decrease in the expression density of CD20 on B-lymphocytes, and an increase in the relative content of memory cells (CD4+CD45RO+-T-lymphocytes and cytotoxic CD8+CD45RO+-T-lymphocytes). Fucoidan extracted from the brown algae Fucus evanescens of the Sea of Okhotsk can be used to increase the effectiveness of seasonal influenza vaccination in the elderly. |
| format | Article |
| id | doaj-art-e6612da65e1348529aa10315b6775730 |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-06-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-e6612da65e1348529aa10315b67757302025-08-20T03:20:32ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-06-01653-4232810.37489/0235-2990-2020-65-3-4-23-28716The Corrective Effect of Fucoidan, a Sulfated Polysaccharide Extracted from Brown Algae Fucus evanescens, in the Formation of a Specific Immune Response Against Seasonal Influenza Viruses in the ElderlyT. S. Zaporozhets0S. P. Kryzhanovsky1E. V. Persianova2T. A. Kuznetsova3T. P. Smolina4A. K. Gazha5N. M. Shevchenko6S. P. Ermakova7T. N. Zvyagintseva8N. N. Besednova9Somov Research Institute of Epidemiology and MicrobiologyMedical Association of the Far East Branch of the Russian Academy of SciencesMedical Association of the Far East Branch of the Russian Academy of SciencesSomov Research Institute of Epidemiology and MicrobiologySomov Research Institute of Epidemiology and MicrobiologySomov Research Institute of Epidemiology and MicrobiologyG.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far East Branch of the Russian Academy of SciencesG.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far East Branch of the Russian Academy of SciencesG.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far East Branch of the Russian Academy of SciencesSomov Research Institute of Epidemiology and MicrobiologyThe article establishes the particularities of immune system dysfunction in the elderly during formation of a specific immune response to vaccination with a seasonal influenza vaccine depending on the level of seroconversion. The corrective effect of fucoidan — a sulfated polysaccharide extracted from brown algae Fucus evanescens — was shown in the formation of a specific immune response, accompanied by an increase in the expression of the activation molecules CD69 and CD86 on monocytes, a decrease in the expression density of CD20 on B-lymphocytes, and an increase in the relative content of memory cells (CD4+CD45RO+-T-lymphocytes and cytotoxic CD8+CD45RO+-T-lymphocytes). Fucoidan extracted from the brown algae Fucus evanescens of the Sea of Okhotsk can be used to increase the effectiveness of seasonal influenza vaccination in the elderly.https://www.antibiotics-chemotherapy.ru/jour/article/view/718vaccinationinfluenzaadjuvantsfucoidansulfated polysaccharidesbrown algaeelderly people |
| spellingShingle | T. S. Zaporozhets S. P. Kryzhanovsky E. V. Persianova T. A. Kuznetsova T. P. Smolina A. K. Gazha N. M. Shevchenko S. P. Ermakova T. N. Zvyagintseva N. N. Besednova The Corrective Effect of Fucoidan, a Sulfated Polysaccharide Extracted from Brown Algae Fucus evanescens, in the Formation of a Specific Immune Response Against Seasonal Influenza Viruses in the Elderly Антибиотики и Химиотерапия vaccination influenza adjuvants fucoidan sulfated polysaccharides brown algae elderly people |
| title | The Corrective Effect of Fucoidan, a Sulfated Polysaccharide Extracted from Brown Algae Fucus evanescens, in the Formation of a Specific Immune Response Against Seasonal Influenza Viruses in the Elderly |
| title_full | The Corrective Effect of Fucoidan, a Sulfated Polysaccharide Extracted from Brown Algae Fucus evanescens, in the Formation of a Specific Immune Response Against Seasonal Influenza Viruses in the Elderly |
| title_fullStr | The Corrective Effect of Fucoidan, a Sulfated Polysaccharide Extracted from Brown Algae Fucus evanescens, in the Formation of a Specific Immune Response Against Seasonal Influenza Viruses in the Elderly |
| title_full_unstemmed | The Corrective Effect of Fucoidan, a Sulfated Polysaccharide Extracted from Brown Algae Fucus evanescens, in the Formation of a Specific Immune Response Against Seasonal Influenza Viruses in the Elderly |
| title_short | The Corrective Effect of Fucoidan, a Sulfated Polysaccharide Extracted from Brown Algae Fucus evanescens, in the Formation of a Specific Immune Response Against Seasonal Influenza Viruses in the Elderly |
| title_sort | corrective effect of fucoidan a sulfated polysaccharide extracted from brown algae fucus evanescens in the formation of a specific immune response against seasonal influenza viruses in the elderly |
| topic | vaccination influenza adjuvants fucoidan sulfated polysaccharides brown algae elderly people |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/718 |
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