Clustered Regularly Interspersed Short Palindromic Repeats Gene Editing: Precision Medicine and Newer Therapies for Retinal Dystrophies
Personalized medicine with the development of targeted therapies toward clinical disorders is predicted to be the future of medicine. Ophthalmology is at the forefront of the development of newer therapies, as the eye forms an excellent target for the development of such therapies given the accessib...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Delhi Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/DLJO.DLJO_16_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850279978716889088 |
|---|---|
| author | Mayank Bansal |
| author_facet | Mayank Bansal |
| author_sort | Mayank Bansal |
| collection | DOAJ |
| description | Personalized medicine with the development of targeted therapies toward clinical disorders is predicted to be the future of medicine. Ophthalmology is at the forefront of the development of newer therapies, as the eye forms an excellent target for the development of such therapies given the accessibility of eye to interventions, the immune privilege, and ability to directly monitor response to interventions. Within ophthalmology, inherited retinal dystrophies (IRDs) form a dynamic area of research, as no definitive therapy exists for such a blinding eye condition. There are various approaches in research, and in early clinical trials for treating IRDs including Food and Drug Administration approved gene therapy Voretegene neparvovec for retinal pigment epithelium 65 gene associated Leber’s Congenital Amaurosis, Argus II bionic eye, and regenerative therapies such as stem cells. This narrative review delves deeper into Clustered Regularly Interspersed Short Palindromic Repeats gene editing-based therapies for the management of IRDs, the advantages, limitations, current research, and future direction. |
| format | Article |
| id | doaj-art-e65ee1e5fc46434ab87f999b19a0aa8d |
| institution | OA Journals |
| issn | 0972-0200 2454-2784 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Delhi Journal of Ophthalmology |
| spelling | doaj-art-e65ee1e5fc46434ab87f999b19a0aa8d2025-08-20T01:48:54ZengWolters Kluwer Medknow PublicationsDelhi Journal of Ophthalmology0972-02002454-27842023-01-01331767810.4103/DLJO.DLJO_16_23Clustered Regularly Interspersed Short Palindromic Repeats Gene Editing: Precision Medicine and Newer Therapies for Retinal DystrophiesMayank BansalPersonalized medicine with the development of targeted therapies toward clinical disorders is predicted to be the future of medicine. Ophthalmology is at the forefront of the development of newer therapies, as the eye forms an excellent target for the development of such therapies given the accessibility of eye to interventions, the immune privilege, and ability to directly monitor response to interventions. Within ophthalmology, inherited retinal dystrophies (IRDs) form a dynamic area of research, as no definitive therapy exists for such a blinding eye condition. There are various approaches in research, and in early clinical trials for treating IRDs including Food and Drug Administration approved gene therapy Voretegene neparvovec for retinal pigment epithelium 65 gene associated Leber’s Congenital Amaurosis, Argus II bionic eye, and regenerative therapies such as stem cells. This narrative review delves deeper into Clustered Regularly Interspersed Short Palindromic Repeats gene editing-based therapies for the management of IRDs, the advantages, limitations, current research, and future direction.https://journals.lww.com/10.4103/DLJO.DLJO_16_23adenine base editorclustered regularly interspersed short palindromic repeatshomology-directed repairnonhomologous end joining |
| spellingShingle | Mayank Bansal Clustered Regularly Interspersed Short Palindromic Repeats Gene Editing: Precision Medicine and Newer Therapies for Retinal Dystrophies Delhi Journal of Ophthalmology adenine base editor clustered regularly interspersed short palindromic repeats homology-directed repair nonhomologous end joining |
| title | Clustered Regularly Interspersed Short Palindromic Repeats Gene Editing: Precision Medicine and Newer Therapies for Retinal Dystrophies |
| title_full | Clustered Regularly Interspersed Short Palindromic Repeats Gene Editing: Precision Medicine and Newer Therapies for Retinal Dystrophies |
| title_fullStr | Clustered Regularly Interspersed Short Palindromic Repeats Gene Editing: Precision Medicine and Newer Therapies for Retinal Dystrophies |
| title_full_unstemmed | Clustered Regularly Interspersed Short Palindromic Repeats Gene Editing: Precision Medicine and Newer Therapies for Retinal Dystrophies |
| title_short | Clustered Regularly Interspersed Short Palindromic Repeats Gene Editing: Precision Medicine and Newer Therapies for Retinal Dystrophies |
| title_sort | clustered regularly interspersed short palindromic repeats gene editing precision medicine and newer therapies for retinal dystrophies |
| topic | adenine base editor clustered regularly interspersed short palindromic repeats homology-directed repair nonhomologous end joining |
| url | https://journals.lww.com/10.4103/DLJO.DLJO_16_23 |
| work_keys_str_mv | AT mayankbansal clusteredregularlyinterspersedshortpalindromicrepeatsgeneeditingprecisionmedicineandnewertherapiesforretinaldystrophies |