Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability
Cognitive dysfunction affects 40–65% of multiple sclerosis (MS) patients and can occur in the early stages of the disease. This study aimed to explore cognitive functions by means of the Italian version of the minimal assessment of cognitive function in MS (MACFIMS) in relapsing-remitting MS (RRMS)...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2017/7404289 |
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| author | S. Migliore A. Ghazaryan I. Simonelli P. Pasqualetti F. Squitieri G. Curcio D. Landi M. G. Palmieri F. Moffa M. M. Filippi F. Vernieri |
| author_facet | S. Migliore A. Ghazaryan I. Simonelli P. Pasqualetti F. Squitieri G. Curcio D. Landi M. G. Palmieri F. Moffa M. M. Filippi F. Vernieri |
| author_sort | S. Migliore |
| collection | DOAJ |
| description | Cognitive dysfunction affects 40–65% of multiple sclerosis (MS) patients and can occur in the early stages of the disease. This study aimed to explore cognitive functions by means of the Italian version of the minimal assessment of cognitive function in MS (MACFIMS) in relapsing-remitting MS (RRMS) patients with very mild clinical disability to identify the primarily involved cognitive functions. Ninety-two consecutive RRMS patients with Expanded Disability Status Scale (EDSS) scores ≤ 2.5 and forty-two healthy controls (HC) were investigated. Our results show that 51.1% of MS patients have cognitive dysfunction compared to HC. An impairment of verbal and visual memory, working memory, and executive functions was found in the RRMS group. After subgrouping RRMS by EDSS, group 1 (EDSS ≤ 1.5) showed involvement of verbal memory and executive functions; moreover, group 2 (2 ≤ EDSS ≤ 2.5) patients were also impaired in information processing speed and visual memory. Our results show that utilizing a comprehensive neuropsychological assessment, approximately half of MS patients with very mild physical disability exhibit cognitive impairment with a primary involvement of prefrontal cognitive functions. Detecting impairment of executive functions at an early clinical stage of disease could be useful to promptly enroll MS patients in targeted rehabilitation. |
| format | Article |
| id | doaj-art-e659fc078e9a42ba940264d894b37ef4 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-e659fc078e9a42ba940264d894b37ef42025-02-03T06:45:56ZengWileyBehavioural Neurology0953-41801875-85842017-01-01201710.1155/2017/74042897404289Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical DisabilityS. Migliore0A. Ghazaryan1I. Simonelli2P. Pasqualetti3F. Squitieri4G. Curcio5D. Landi6M. G. Palmieri7F. Moffa8M. M. Filippi9F. Vernieri10Clinical Psychology, University Campus Bio-Medico of Rome, Rome, ItalyDepartment of Neuroscience, Fatebenefratelli Hospital-Isola Tiberina, Rome, ItalyService of Medical Statistics and Information Technology (SeSMIT), Fatebenefratelli Hospital-Isola Tiberina, Rome, ItalyService of Medical Statistics and Information Technology (SeSMIT), Fatebenefratelli Hospital-Isola Tiberina, Rome, ItalyIRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, ItalyDepartment of Neuroscience, Policlinico “Tor Vergata”, Rome, ItalyDepartment of Neuroscience, Policlinico “Tor Vergata”, Rome, ItalyDepartment of Neuroscience, Fatebenefratelli Hospital-Isola Tiberina, Rome, ItalyDepartment of Neuroscience, Fatebenefratelli Hospital-Isola Tiberina, Rome, ItalyNeurology Unit, University Campus Bio-Medico of Rome, Rome, ItalyCognitive dysfunction affects 40–65% of multiple sclerosis (MS) patients and can occur in the early stages of the disease. This study aimed to explore cognitive functions by means of the Italian version of the minimal assessment of cognitive function in MS (MACFIMS) in relapsing-remitting MS (RRMS) patients with very mild clinical disability to identify the primarily involved cognitive functions. Ninety-two consecutive RRMS patients with Expanded Disability Status Scale (EDSS) scores ≤ 2.5 and forty-two healthy controls (HC) were investigated. Our results show that 51.1% of MS patients have cognitive dysfunction compared to HC. An impairment of verbal and visual memory, working memory, and executive functions was found in the RRMS group. After subgrouping RRMS by EDSS, group 1 (EDSS ≤ 1.5) showed involvement of verbal memory and executive functions; moreover, group 2 (2 ≤ EDSS ≤ 2.5) patients were also impaired in information processing speed and visual memory. Our results show that utilizing a comprehensive neuropsychological assessment, approximately half of MS patients with very mild physical disability exhibit cognitive impairment with a primary involvement of prefrontal cognitive functions. Detecting impairment of executive functions at an early clinical stage of disease could be useful to promptly enroll MS patients in targeted rehabilitation.http://dx.doi.org/10.1155/2017/7404289 |
| spellingShingle | S. Migliore A. Ghazaryan I. Simonelli P. Pasqualetti F. Squitieri G. Curcio D. Landi M. G. Palmieri F. Moffa M. M. Filippi F. Vernieri Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability Behavioural Neurology |
| title | Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability |
| title_full | Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability |
| title_fullStr | Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability |
| title_full_unstemmed | Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability |
| title_short | Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability |
| title_sort | cognitive impairment in relapsing remitting multiple sclerosis patients with very mild clinical disability |
| url | http://dx.doi.org/10.1155/2017/7404289 |
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