Level of long noncoding RNA taurine upregulated gene 1 after narrow band-ultraviolet B phototherapy in vitiligo
Background Vitiligo is a skin disease that is characterized by depigmenting lesions as a result of melanocytes destruction. Long noncoding Taurine upregulated gene 1 (lnc TUG-1) is one of the long noncoding RNA (lnc RNA) family members. The role of lncRNA TUG1 in melanogenesis has been investigated...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-05-01
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| Series: | Journal of the Egyptian Women’s Dermatologic Society |
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| Online Access: | https://journals.lww.com/10.4103/jewd.jewd_76_23 |
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| author | Reham W. Doss Laila A. Rashed Hanaa Ibrahim Rehab M. Naguib |
| author_facet | Reham W. Doss Laila A. Rashed Hanaa Ibrahim Rehab M. Naguib |
| author_sort | Reham W. Doss |
| collection | DOAJ |
| description | Background
Vitiligo is a skin disease that is characterized by depigmenting lesions as a result of melanocytes destruction. Long noncoding Taurine upregulated gene 1 (lnc TUG-1) is one of the long noncoding RNA (lnc RNA) family members. The role of lncRNA TUG1 in melanogenesis has been investigated in recent studies.
Objective
To investigate the impact of narrow-band ultraviolet B (NB-UVB) on lncTUG-1 expression in vitiligo.
Patients and methods
The first step of this work was a case control study that included thirty vitiligo patients and thirty healthy controls. four mm skin biopsies were taken from normal skin in healthy controls and from depigmenting lesions in vitiligo patients. The second step was a prospective single-arm interventional study in which patients were subjected to 12 weeks of NB-UVB phototherapy and biopsies were taken from repigmenting areas. Biopsies were kept frozen at −80°C till by real-time polymerase chain reaction was conducted to evaluate the lnc TUG-1 expression.
Results
The mean lnc TUG-1 expression in skin tissue biopsies of the vitiligo patients was significantly lower compared with control skin biopsies (0.307±0.202 ng/mg vs 1.03±0.063 pg/mg, respectively, P<0.001). Although the level of lnc TUG-1 was not normalized, the mean value of lnc TUG-1 significantly increased after 12 weeks treatment with NB-UVB compared with its value before phototherapy (0.0687 ng/mg vs. 0.307 ng/mg, respectively, P<0.001).
Conclusion
The lnc TUG-1 could be a possible player in the pathogenesis of vitiligo and repigmentation of vitiligo after NB-UVB phototherapy. |
| format | Article |
| id | doaj-art-e659617ee26e4d33b429ea6c639a4872 |
| institution | OA Journals |
| issn | 2090-2565 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Egyptian Women’s Dermatologic Society |
| spelling | doaj-art-e659617ee26e4d33b429ea6c639a48722025-08-20T02:01:19ZengWolters Kluwer Medknow PublicationsJournal of the Egyptian Women’s Dermatologic Society2090-25652024-05-0121213213610.4103/jewd.jewd_76_23Level of long noncoding RNA taurine upregulated gene 1 after narrow band-ultraviolet B phototherapy in vitiligoReham W. DossLaila A. RashedHanaa IbrahimRehab M. NaguibBackground Vitiligo is a skin disease that is characterized by depigmenting lesions as a result of melanocytes destruction. Long noncoding Taurine upregulated gene 1 (lnc TUG-1) is one of the long noncoding RNA (lnc RNA) family members. The role of lncRNA TUG1 in melanogenesis has been investigated in recent studies. Objective To investigate the impact of narrow-band ultraviolet B (NB-UVB) on lncTUG-1 expression in vitiligo. Patients and methods The first step of this work was a case control study that included thirty vitiligo patients and thirty healthy controls. four mm skin biopsies were taken from normal skin in healthy controls and from depigmenting lesions in vitiligo patients. The second step was a prospective single-arm interventional study in which patients were subjected to 12 weeks of NB-UVB phototherapy and biopsies were taken from repigmenting areas. Biopsies were kept frozen at −80°C till by real-time polymerase chain reaction was conducted to evaluate the lnc TUG-1 expression. Results The mean lnc TUG-1 expression in skin tissue biopsies of the vitiligo patients was significantly lower compared with control skin biopsies (0.307±0.202 ng/mg vs 1.03±0.063 pg/mg, respectively, P<0.001). Although the level of lnc TUG-1 was not normalized, the mean value of lnc TUG-1 significantly increased after 12 weeks treatment with NB-UVB compared with its value before phototherapy (0.0687 ng/mg vs. 0.307 ng/mg, respectively, P<0.001). Conclusion The lnc TUG-1 could be a possible player in the pathogenesis of vitiligo and repigmentation of vitiligo after NB-UVB phototherapy.https://journals.lww.com/10.4103/jewd.jewd_76_23polymerase chain reactionphototherapytaurine upregulated gene 1vitiligo |
| spellingShingle | Reham W. Doss Laila A. Rashed Hanaa Ibrahim Rehab M. Naguib Level of long noncoding RNA taurine upregulated gene 1 after narrow band-ultraviolet B phototherapy in vitiligo Journal of the Egyptian Women’s Dermatologic Society polymerase chain reaction phototherapy taurine upregulated gene 1 vitiligo |
| title | Level of long noncoding RNA taurine upregulated gene 1 after narrow band-ultraviolet B phototherapy in vitiligo |
| title_full | Level of long noncoding RNA taurine upregulated gene 1 after narrow band-ultraviolet B phototherapy in vitiligo |
| title_fullStr | Level of long noncoding RNA taurine upregulated gene 1 after narrow band-ultraviolet B phototherapy in vitiligo |
| title_full_unstemmed | Level of long noncoding RNA taurine upregulated gene 1 after narrow band-ultraviolet B phototherapy in vitiligo |
| title_short | Level of long noncoding RNA taurine upregulated gene 1 after narrow band-ultraviolet B phototherapy in vitiligo |
| title_sort | level of long noncoding rna taurine upregulated gene 1 after narrow band ultraviolet b phototherapy in vitiligo |
| topic | polymerase chain reaction phototherapy taurine upregulated gene 1 vitiligo |
| url | https://journals.lww.com/10.4103/jewd.jewd_76_23 |
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