Enhanced functionalities of biomaterials through metal ion surface modification
The development of new artificial biomaterials for bone defect repair is an ongoing area of clinical research. Metal ions such as zinc, copper, magnesium, calcium, strontium, silver, and cerium play various roles in bone tissue regeneration in the human body and possess a range of biochemical functi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1522442/full |
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| author | Yujie Tao Wayne Nishio Ayre Liming Jiang Siyu Chen Yuqi Dong Lin Wu Yilai Jiao Xiaohan Liu |
| author_facet | Yujie Tao Wayne Nishio Ayre Liming Jiang Siyu Chen Yuqi Dong Lin Wu Yilai Jiao Xiaohan Liu |
| author_sort | Yujie Tao |
| collection | DOAJ |
| description | The development of new artificial biomaterials for bone defect repair is an ongoing area of clinical research. Metal ions such as zinc, copper, magnesium, calcium, strontium, silver, and cerium play various roles in bone tissue regeneration in the human body and possess a range of biochemical functions. Studies have demonstrated that appropriate concentrations of these metal ions can promote osteogenesis and angiogenesis, inhibit osteoclast activity, and deter bacterial infections. Researchers have incorporated metal ions into biomaterials using various methods to create artificial bone materials with enhanced osteogenic and antibacterial capabilities. In addition to the osteogenic properties of all the aforementioned metal ions, Zn, Sr, and Ce can indirectly promote osteogenesis by inhibiting osteoclast activity. Cu, Mg, and Sr significantly enhance angiogenesis, while the antibacterial properties of Zn, Cu, Ag, and Ce can reduce the likelihood of infection and inflammation caused by implanted materials. This paper reviews the mechanisms through which metal ions promote bone tissue growth and improve the antibacterial activity of biomaterials. It also summarizes common loading methods on the surface of biomaterials with different metals and highlights the potential clinical applications of these new artificial bone materials. |
| format | Article |
| id | doaj-art-e655313b9f314da5ab0f6efe09462c59 |
| institution | DOAJ |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-e655313b9f314da5ab0f6efe09462c592025-08-20T03:10:09ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-04-011310.3389/fbioe.2025.15224421522442Enhanced functionalities of biomaterials through metal ion surface modificationYujie Tao0Wayne Nishio Ayre1Liming Jiang2Siyu Chen3Yuqi Dong4Lin Wu5Yilai Jiao6Xiaohan Liu7School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, ChinaSchool of Dentistry, Cardiff University, Cardiff, United KingdomSchool and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, ChinaSchool and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, ChinaSchool and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, ChinaSchool and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, ChinaChinese Academy of Sciences Shenyang Branch, Shenyang, ChinaSchool and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, ChinaThe development of new artificial biomaterials for bone defect repair is an ongoing area of clinical research. Metal ions such as zinc, copper, magnesium, calcium, strontium, silver, and cerium play various roles in bone tissue regeneration in the human body and possess a range of biochemical functions. Studies have demonstrated that appropriate concentrations of these metal ions can promote osteogenesis and angiogenesis, inhibit osteoclast activity, and deter bacterial infections. Researchers have incorporated metal ions into biomaterials using various methods to create artificial bone materials with enhanced osteogenic and antibacterial capabilities. In addition to the osteogenic properties of all the aforementioned metal ions, Zn, Sr, and Ce can indirectly promote osteogenesis by inhibiting osteoclast activity. Cu, Mg, and Sr significantly enhance angiogenesis, while the antibacterial properties of Zn, Cu, Ag, and Ce can reduce the likelihood of infection and inflammation caused by implanted materials. This paper reviews the mechanisms through which metal ions promote bone tissue growth and improve the antibacterial activity of biomaterials. It also summarizes common loading methods on the surface of biomaterials with different metals and highlights the potential clinical applications of these new artificial bone materials.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1522442/fullbone defect repairmetal ionsosteogenesisantibacterial activitybiomaterials |
| spellingShingle | Yujie Tao Wayne Nishio Ayre Liming Jiang Siyu Chen Yuqi Dong Lin Wu Yilai Jiao Xiaohan Liu Enhanced functionalities of biomaterials through metal ion surface modification Frontiers in Bioengineering and Biotechnology bone defect repair metal ions osteogenesis antibacterial activity biomaterials |
| title | Enhanced functionalities of biomaterials through metal ion surface modification |
| title_full | Enhanced functionalities of biomaterials through metal ion surface modification |
| title_fullStr | Enhanced functionalities of biomaterials through metal ion surface modification |
| title_full_unstemmed | Enhanced functionalities of biomaterials through metal ion surface modification |
| title_short | Enhanced functionalities of biomaterials through metal ion surface modification |
| title_sort | enhanced functionalities of biomaterials through metal ion surface modification |
| topic | bone defect repair metal ions osteogenesis antibacterial activity biomaterials |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1522442/full |
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