MTAP deficiency is highly homogeneous in advanced, muscle-invasive urothelial carcinoma of the urinary bladder

MTAP deficiency is highly homogeneous in advanced, muscle-invasive urothelial carcinoma of the urinary bladder

Abstract Complete expression loss of S-methyl-5′-thioadenosine phosphorylase (MTAP) is caused by homozygous 9p21 deletion and results in a critical vulnerability of cancer cells towards drugs targeting multiple different pathways. MTAP deficiency is common in urothelial cancer, but data on its intra...

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Main Authors: Natalia Gorbokon, Katharina Teljuk, Viktor Reiswich, Florian Lutz, Sebastian Dwertmann Rico, Clara Lühr, Christian Bernreuther, Yaryna Klos Al Bunni, Cosima Völkel, Henning Plage, Maximilian Lennartz, Margit Fisch, Sarah Minner, Ronald Simon, Guido Sauter, Henrik Zecha, Stefan Steurer, Thorsten Schlomm, Tatjana Vlajnic, Lukas Bubendorf, Michael Rink, Martina Kluth, Florian Viehweger, Morton Freytag
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
MTAP deficiency
FISH
IHC
Tissue microarray
Urothelial bladder cancer
Tumor heterogeneity
Online Access:https://doi.org/10.1038/s41598-025-10157-0
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