Effects of Subchronic Exposure to Cadmium and Diazinon on Testis and Epididymis in Rats
The present study aimed to elucidate the structural changes in testis and epididymis of adult rats following subchronic peroral administration of cadmium at 30 mg/L, diazinon at 40 mg/L, cadmium at 30 mg/L, and diazinon at 40 mg/L, respectively. At the end of 90-day experiment, the samples of the te...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/632581 |
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| author | Maria Adamkovicova Robert Toman Michal Cabaj Peter Massanyi Monika Martiniakova Radoslav Omelka Vladimira Krajcovicova Hana Duranova |
| author_facet | Maria Adamkovicova Robert Toman Michal Cabaj Peter Massanyi Monika Martiniakova Radoslav Omelka Vladimira Krajcovicova Hana Duranova |
| author_sort | Maria Adamkovicova |
| collection | DOAJ |
| description | The present study aimed to elucidate the structural changes in testis and epididymis of adult rats following subchronic peroral administration of cadmium at 30 mg/L, diazinon at 40 mg/L, cadmium at 30 mg/L, and diazinon at 40 mg/L, respectively. At the end of 90-day experiment, the samples of the testes and epididymis were assayed by qualitative and quantitative histological methods. The testis and epididymis weights increased following exposure to cadmium and simultaneous exposure to cadmium and diazinon. Testicular damage following cadmium and diazinon coexposure was significantly less expressive than in groups with individual administration of these compounds. Cadmium caused a significant thickening of seminiferous epithelium, cellular degeneration, and necrosis. Desquamation of immature germ cells resulted in a significant increase of intraepithelial spaces and reduced tubule volume in all experimental groups. Vascular dilation and congestion were detected in the interstitial tissue. The changes in epididymal histology in the group exposed to cadmium and group exposed simultaneously included a reduction of epithelium, necrotic epithelial cells, vasoconstriction, and interstitial edema together with mononuclear cell infiltration. Results did not indicate a synergistic or any additional effect from the simultaneous administration of both toxicants. Further research is needed to determine the significance and the mechanism of the adverse effects. |
| format | Article |
| id | doaj-art-e64f62b9d1d54e15bc09c2c6224a53ef |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e64f62b9d1d54e15bc09c2c6224a53ef2025-02-03T06:00:25ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/632581632581Effects of Subchronic Exposure to Cadmium and Diazinon on Testis and Epididymis in RatsMaria Adamkovicova0Robert Toman1Michal Cabaj2Peter Massanyi3Monika Martiniakova4Radoslav Omelka5Vladimira Krajcovicova6Hana Duranova7Department of Botany and Genetics, Constantine the Philosopher University, Nitra 949 74, SlovakiaDepartment of Veterinary Disciplines, Slovak University of Agriculture, Nitra 949 76, SlovakiaDepartment of Veterinary Disciplines, Slovak University of Agriculture, Nitra 949 76, SlovakiaDepartment of Animal Physiology, Slovak University of Agriculture, Nitra 949 76, SlovakiaDepartment of Zoology and Anthropology, Constantine the Philosopher University, Nitra 949 74, SlovakiaDepartment of Botany and Genetics, Constantine the Philosopher University, Nitra 949 74, SlovakiaDepartment of Botany and Genetics, Constantine the Philosopher University, Nitra 949 74, SlovakiaDepartment of Zoology and Anthropology, Constantine the Philosopher University, Nitra 949 74, SlovakiaThe present study aimed to elucidate the structural changes in testis and epididymis of adult rats following subchronic peroral administration of cadmium at 30 mg/L, diazinon at 40 mg/L, cadmium at 30 mg/L, and diazinon at 40 mg/L, respectively. At the end of 90-day experiment, the samples of the testes and epididymis were assayed by qualitative and quantitative histological methods. The testis and epididymis weights increased following exposure to cadmium and simultaneous exposure to cadmium and diazinon. Testicular damage following cadmium and diazinon coexposure was significantly less expressive than in groups with individual administration of these compounds. Cadmium caused a significant thickening of seminiferous epithelium, cellular degeneration, and necrosis. Desquamation of immature germ cells resulted in a significant increase of intraepithelial spaces and reduced tubule volume in all experimental groups. Vascular dilation and congestion were detected in the interstitial tissue. The changes in epididymal histology in the group exposed to cadmium and group exposed simultaneously included a reduction of epithelium, necrotic epithelial cells, vasoconstriction, and interstitial edema together with mononuclear cell infiltration. Results did not indicate a synergistic or any additional effect from the simultaneous administration of both toxicants. Further research is needed to determine the significance and the mechanism of the adverse effects.http://dx.doi.org/10.1155/2014/632581 |
| spellingShingle | Maria Adamkovicova Robert Toman Michal Cabaj Peter Massanyi Monika Martiniakova Radoslav Omelka Vladimira Krajcovicova Hana Duranova Effects of Subchronic Exposure to Cadmium and Diazinon on Testis and Epididymis in Rats The Scientific World Journal |
| title | Effects of Subchronic Exposure to Cadmium and Diazinon on Testis and Epididymis in Rats |
| title_full | Effects of Subchronic Exposure to Cadmium and Diazinon on Testis and Epididymis in Rats |
| title_fullStr | Effects of Subchronic Exposure to Cadmium and Diazinon on Testis and Epididymis in Rats |
| title_full_unstemmed | Effects of Subchronic Exposure to Cadmium and Diazinon on Testis and Epididymis in Rats |
| title_short | Effects of Subchronic Exposure to Cadmium and Diazinon on Testis and Epididymis in Rats |
| title_sort | effects of subchronic exposure to cadmium and diazinon on testis and epididymis in rats |
| url | http://dx.doi.org/10.1155/2014/632581 |
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