Association and dynamic change of fecal calprotectin with sepsis associated liver dysfunction in adults with sepsis
Abstract Fecal calprotectin (FC) is a biomarker of gut inflammation but its association with sepsis associated liver dysfunction (SALD) is unclear. This single-center, prospective cohort study investigated the relationship between FC and SALD in adults with sepsis. FC concentrations were measured on...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-98904-1 |
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| author | Beiyuan Zhang Chenzhe He Ting Su Zimeng Qin Qi Cheng Zhanghua Zhu Ming Chen Wenkui Yu |
| author_facet | Beiyuan Zhang Chenzhe He Ting Su Zimeng Qin Qi Cheng Zhanghua Zhu Ming Chen Wenkui Yu |
| author_sort | Beiyuan Zhang |
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| description | Abstract Fecal calprotectin (FC) is a biomarker of gut inflammation but its association with sepsis associated liver dysfunction (SALD) is unclear. This single-center, prospective cohort study investigated the relationship between FC and SALD in adults with sepsis. FC concentrations were measured on days 1 (FC1) and 3 (FC3). The difference between FC3 and FC1 (∆FC) was calculated. The relationship between FC and SALD was assessed using multivariate analysis. Receiver operating characteristic curves were used to assess the predictive value of SALD biomarkers. Ninety-five patients with sepsis (33 with SALD and 62 without SALD) were enrolled between January 2023 and March 2024. The median FC3 level and ∆FC were significantly higher in the SALD group than in the non-SALD group (both p < 0.001), whereas the median FC1 level did not differ significantly between groups. FC3 level and ∆FC were positively associated with SALD in the adjusted analysis (both p < 0.001) with areas under the curve of 0.784 and 0.848, respectively, and cut-off values of 930.88 μg/g and − 8.80 μg/g, respectively. In adults with sepsis, SALD occurrence was more strongly associated with elevated FC3 levels and ∆FC than with FC1 levels; therefore, monitoring FC3 levels and ∆FC could help detect SALD. |
| format | Article |
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| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-e64ed9ed631f4d30b68d39f897b2e6952025-08-20T02:03:31ZengNature PortfolioScientific Reports2045-23222025-05-0115111110.1038/s41598-025-98904-1Association and dynamic change of fecal calprotectin with sepsis associated liver dysfunction in adults with sepsisBeiyuan Zhang0Chenzhe He1Ting Su2Zimeng Qin3Qi Cheng4Zhanghua Zhu5Ming Chen6Wenkui Yu7Department of Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityNanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityDepartment of Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityNanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityDepartment of Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityAbstract Fecal calprotectin (FC) is a biomarker of gut inflammation but its association with sepsis associated liver dysfunction (SALD) is unclear. This single-center, prospective cohort study investigated the relationship between FC and SALD in adults with sepsis. FC concentrations were measured on days 1 (FC1) and 3 (FC3). The difference between FC3 and FC1 (∆FC) was calculated. The relationship between FC and SALD was assessed using multivariate analysis. Receiver operating characteristic curves were used to assess the predictive value of SALD biomarkers. Ninety-five patients with sepsis (33 with SALD and 62 without SALD) were enrolled between January 2023 and March 2024. The median FC3 level and ∆FC were significantly higher in the SALD group than in the non-SALD group (both p < 0.001), whereas the median FC1 level did not differ significantly between groups. FC3 level and ∆FC were positively associated with SALD in the adjusted analysis (both p < 0.001) with areas under the curve of 0.784 and 0.848, respectively, and cut-off values of 930.88 μg/g and − 8.80 μg/g, respectively. In adults with sepsis, SALD occurrence was more strongly associated with elevated FC3 levels and ∆FC than with FC1 levels; therefore, monitoring FC3 levels and ∆FC could help detect SALD.https://doi.org/10.1038/s41598-025-98904-1Fecal calprotectinSepsisSepsis associated liver dysfunctionAdult |
| spellingShingle | Beiyuan Zhang Chenzhe He Ting Su Zimeng Qin Qi Cheng Zhanghua Zhu Ming Chen Wenkui Yu Association and dynamic change of fecal calprotectin with sepsis associated liver dysfunction in adults with sepsis Scientific Reports Fecal calprotectin Sepsis Sepsis associated liver dysfunction Adult |
| title | Association and dynamic change of fecal calprotectin with sepsis associated liver dysfunction in adults with sepsis |
| title_full | Association and dynamic change of fecal calprotectin with sepsis associated liver dysfunction in adults with sepsis |
| title_fullStr | Association and dynamic change of fecal calprotectin with sepsis associated liver dysfunction in adults with sepsis |
| title_full_unstemmed | Association and dynamic change of fecal calprotectin with sepsis associated liver dysfunction in adults with sepsis |
| title_short | Association and dynamic change of fecal calprotectin with sepsis associated liver dysfunction in adults with sepsis |
| title_sort | association and dynamic change of fecal calprotectin with sepsis associated liver dysfunction in adults with sepsis |
| topic | Fecal calprotectin Sepsis Sepsis associated liver dysfunction Adult |
| url | https://doi.org/10.1038/s41598-025-98904-1 |
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