Synthesis and Characterization of New 2-Quinolone Sulfonamide Derivatives
A series of new 2-quinolone derivatives linked to benzene sulphonyl moieties were performed by many steps: the first step involved preparation of different coumarins (A1,A2) by condensation of different substituted phenols with ethyl acetoacetate. The compound A1 was treated with nitric acid to affo...
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| Format: | Article |
| Language: | English |
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University of Baghdad, College of Science for Women
2016-12-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2323 |
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| author | Baghdad Science Journal |
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| author_sort | Baghdad Science Journal |
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| description | A series of new 2-quinolone derivatives linked to benzene sulphonyl moieties were performed by many steps: the first step involved preparation of different coumarins (A1,A2) by condensation of different substituted phenols with ethyl acetoacetate. The compound A1 was treated with nitric acid to afford two isomers of nitrocoumarin derivatives (A3) and (A4). The prepared compounds (A2, A3) were treated with hydrazine hydrate to synthesize different 2-quinolone compounds (A5,A6) while the coumarin treated with different amines gave compounds (A7,A8). Then the synthesized 2-quinolone compounds (A5-A8) treated with benzene sulphonyl chloride to afford new sulfonamide derivatives (A9-A12). The synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR spectra and by measurement some of their physical properties. |
| format | Article |
| id | doaj-art-e64d6a3d525f4a4991de0f6840250ca9 |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-e64d6a3d525f4a4991de0f6840250ca92025-08-20T03:57:59ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862016-12-0113410.21123/bsj.13.4.806-818Synthesis and Characterization of New 2-Quinolone Sulfonamide DerivativesBaghdad Science JournalA series of new 2-quinolone derivatives linked to benzene sulphonyl moieties were performed by many steps: the first step involved preparation of different coumarins (A1,A2) by condensation of different substituted phenols with ethyl acetoacetate. The compound A1 was treated with nitric acid to afford two isomers of nitrocoumarin derivatives (A3) and (A4). The prepared compounds (A2, A3) were treated with hydrazine hydrate to synthesize different 2-quinolone compounds (A5,A6) while the coumarin treated with different amines gave compounds (A7,A8). Then the synthesized 2-quinolone compounds (A5-A8) treated with benzene sulphonyl chloride to afford new sulfonamide derivatives (A9-A12). The synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR spectra and by measurement some of their physical properties.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2323"2-quinolones, coumarin, sulfonamide." |
| spellingShingle | Baghdad Science Journal Synthesis and Characterization of New 2-Quinolone Sulfonamide Derivatives مجلة بغداد للعلوم "2-quinolones, coumarin, sulfonamide." |
| title | Synthesis and Characterization of New 2-Quinolone Sulfonamide Derivatives |
| title_full | Synthesis and Characterization of New 2-Quinolone Sulfonamide Derivatives |
| title_fullStr | Synthesis and Characterization of New 2-Quinolone Sulfonamide Derivatives |
| title_full_unstemmed | Synthesis and Characterization of New 2-Quinolone Sulfonamide Derivatives |
| title_short | Synthesis and Characterization of New 2-Quinolone Sulfonamide Derivatives |
| title_sort | synthesis and characterization of new 2 quinolone sulfonamide derivatives |
| topic | "2-quinolones, coumarin, sulfonamide." |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2323 |
| work_keys_str_mv | AT baghdadsciencejournal synthesisandcharacterizationofnew2quinolonesulfonamidederivatives |