Emerging Evidence concerning the Role of Sirtuins in Sepsis

Sepsis, a dysregulated host response to infection, is a major public health concern. Though experimental and clinical studies relating to sepsis are increasing, the mechanism of sepsis is not completely understood. To date, numerous studies have shown that sirtuins (silent mating type information re...

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Main Authors: Lulan Li, Zhongqing Chen, Weijun Fu, Shumin Cai, Zhenhua Zeng
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Critical Care Research and Practice
Online Access:http://dx.doi.org/10.1155/2018/5489571
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author Lulan Li
Zhongqing Chen
Weijun Fu
Shumin Cai
Zhenhua Zeng
author_facet Lulan Li
Zhongqing Chen
Weijun Fu
Shumin Cai
Zhenhua Zeng
author_sort Lulan Li
collection DOAJ
description Sepsis, a dysregulated host response to infection, is a major public health concern. Though experimental and clinical studies relating to sepsis are increasing, the mechanism of sepsis is not completely understood. To date, numerous studies have shown that sirtuins (silent mating type information regulation 2 homolog), which belong to the class III histone deacetylases, may have a varied, or even opposite, effect in the pathogenesis of sepsis. Notably, downstream mechanisms of sirtuins are not fully understood. The sirtuin family consists of sirtuins 1–7; among them, sirtuin 1 (SIRT1) is the most studied one, during the development of sepsis. Furthermore, other sirtuin members are also confirmed to be involved in the regulation of inflammatory or metabolic signaling following sepsis. In addition, sirtuins may interact with each other to form a precise regulatory mechanism in different phases of sepsis. Therefore, in this review, by accumulating data from PubMed, we intend to explain the role of sirtuin in sepsis, which we hope will pave the way for further experimental study and the potential future clinical applications of sirtuins.
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spelling doaj-art-e648ac7cdf48428081a6abfb883e4a3d2025-02-03T01:06:43ZengWileyCritical Care Research and Practice2090-13052090-13132018-01-01201810.1155/2018/54895715489571Emerging Evidence concerning the Role of Sirtuins in SepsisLulan Li0Zhongqing Chen1Weijun Fu2Shumin Cai3Zhenhua Zeng4Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, No. 1023, South Shatai Road, Baiyun District, Guangzhou 510515, Guangdong, ChinaDepartment of Critical Care Medicine, Nanfang Hospital, Southern Medical University, No. 1023, South Shatai Road, Baiyun District, Guangzhou 510515, Guangdong, ChinaDepartment of Critical Care Medicine, Nanfang Hospital, Southern Medical University, No. 1023, South Shatai Road, Baiyun District, Guangzhou 510515, Guangdong, ChinaDepartment of Critical Care Medicine, Nanfang Hospital, Southern Medical University, No. 1023, South Shatai Road, Baiyun District, Guangzhou 510515, Guangdong, ChinaDepartment of Critical Care Medicine, Nanfang Hospital, Southern Medical University, No. 1023, South Shatai Road, Baiyun District, Guangzhou 510515, Guangdong, ChinaSepsis, a dysregulated host response to infection, is a major public health concern. Though experimental and clinical studies relating to sepsis are increasing, the mechanism of sepsis is not completely understood. To date, numerous studies have shown that sirtuins (silent mating type information regulation 2 homolog), which belong to the class III histone deacetylases, may have a varied, or even opposite, effect in the pathogenesis of sepsis. Notably, downstream mechanisms of sirtuins are not fully understood. The sirtuin family consists of sirtuins 1–7; among them, sirtuin 1 (SIRT1) is the most studied one, during the development of sepsis. Furthermore, other sirtuin members are also confirmed to be involved in the regulation of inflammatory or metabolic signaling following sepsis. In addition, sirtuins may interact with each other to form a precise regulatory mechanism in different phases of sepsis. Therefore, in this review, by accumulating data from PubMed, we intend to explain the role of sirtuin in sepsis, which we hope will pave the way for further experimental study and the potential future clinical applications of sirtuins.http://dx.doi.org/10.1155/2018/5489571
spellingShingle Lulan Li
Zhongqing Chen
Weijun Fu
Shumin Cai
Zhenhua Zeng
Emerging Evidence concerning the Role of Sirtuins in Sepsis
Critical Care Research and Practice
title Emerging Evidence concerning the Role of Sirtuins in Sepsis
title_full Emerging Evidence concerning the Role of Sirtuins in Sepsis
title_fullStr Emerging Evidence concerning the Role of Sirtuins in Sepsis
title_full_unstemmed Emerging Evidence concerning the Role of Sirtuins in Sepsis
title_short Emerging Evidence concerning the Role of Sirtuins in Sepsis
title_sort emerging evidence concerning the role of sirtuins in sepsis
url http://dx.doi.org/10.1155/2018/5489571
work_keys_str_mv AT lulanli emergingevidenceconcerningtheroleofsirtuinsinsepsis
AT zhongqingchen emergingevidenceconcerningtheroleofsirtuinsinsepsis
AT weijunfu emergingevidenceconcerningtheroleofsirtuinsinsepsis
AT shumincai emergingevidenceconcerningtheroleofsirtuinsinsepsis
AT zhenhuazeng emergingevidenceconcerningtheroleofsirtuinsinsepsis