Accumulation of Trospectomycin by Strains of Salmonella typhimurium, escherichia coli and Haemophilus influenzae
Trospectomycin, unlike aminoglycosidic aminocyclitols, is accumulated by a nonsaturable, energy-independent, diffusional process in Salmonella typhimurium, Escherichia coli and Haemophilus influenzae. A deep rough mutant of S typhimurium was more susceptible and accumulated the drug faster, and F po...
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| Format: | Article |
| Language: | English |
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Wiley
1990-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1990/258273 |
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| _version_ | 1850168066270298112 |
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| author | S Wong LE Bryan |
| author_facet | S Wong LE Bryan |
| author_sort | S Wong |
| collection | DOAJ |
| description | Trospectomycin, unlike aminoglycosidic aminocyclitols, is accumulated by a nonsaturable, energy-independent, diffusional process in Salmonella typhimurium, Escherichia coli and Haemophilus influenzae. A deep rough mutant of S typhimurium was more susceptible and accumulated the drug faster, and F porin deficient mutants of E coli were more resistant than parental strains. Trospectomycin likely uses both porin and nonporin pathways to cross the outer membrane. An E coli strain effectively accumulated the drug anaerobically, explaining its anaerobic activity. An H influenzae strain accumulated trospectomycin at concentrations below those for which detectable uptake could be observed with E coli or S typhimurium strains, consistent with greater activity in Haemophilus species. |
| format | Article |
| id | doaj-art-e6479a75194d43c6893778f937657f94 |
| institution | OA Journals |
| issn | 1180-2332 |
| language | English |
| publishDate | 1990-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases |
| spelling | doaj-art-e6479a75194d43c6893778f937657f942025-08-20T02:21:03ZengWileyCanadian Journal of Infectious Diseases1180-23321990-01-0112515610.1155/1990/258273Accumulation of Trospectomycin by Strains of Salmonella typhimurium, escherichia coli and Haemophilus influenzaeS Wong0LE Bryan1Departments of Microbiology and Infectious Diseases, University of Calgary and Foothills Hospital, Calgary, Alberta, CanadaDepartments of Microbiology and Infectious Diseases, University of Calgary and Foothills Hospital, Calgary, Alberta, CanadaTrospectomycin, unlike aminoglycosidic aminocyclitols, is accumulated by a nonsaturable, energy-independent, diffusional process in Salmonella typhimurium, Escherichia coli and Haemophilus influenzae. A deep rough mutant of S typhimurium was more susceptible and accumulated the drug faster, and F porin deficient mutants of E coli were more resistant than parental strains. Trospectomycin likely uses both porin and nonporin pathways to cross the outer membrane. An E coli strain effectively accumulated the drug anaerobically, explaining its anaerobic activity. An H influenzae strain accumulated trospectomycin at concentrations below those for which detectable uptake could be observed with E coli or S typhimurium strains, consistent with greater activity in Haemophilus species.http://dx.doi.org/10.1155/1990/258273 |
| spellingShingle | S Wong LE Bryan Accumulation of Trospectomycin by Strains of Salmonella typhimurium, escherichia coli and Haemophilus influenzae Canadian Journal of Infectious Diseases |
| title | Accumulation of Trospectomycin by Strains of Salmonella typhimurium, escherichia coli and Haemophilus influenzae |
| title_full | Accumulation of Trospectomycin by Strains of Salmonella typhimurium, escherichia coli and Haemophilus influenzae |
| title_fullStr | Accumulation of Trospectomycin by Strains of Salmonella typhimurium, escherichia coli and Haemophilus influenzae |
| title_full_unstemmed | Accumulation of Trospectomycin by Strains of Salmonella typhimurium, escherichia coli and Haemophilus influenzae |
| title_short | Accumulation of Trospectomycin by Strains of Salmonella typhimurium, escherichia coli and Haemophilus influenzae |
| title_sort | accumulation of trospectomycin by strains of salmonella typhimurium escherichia coli and haemophilus influenzae |
| url | http://dx.doi.org/10.1155/1990/258273 |
| work_keys_str_mv | AT swong accumulationoftrospectomycinbystrainsofsalmonellatyphimuriumescherichiacoliandhaemophilusinfluenzae AT lebryan accumulationoftrospectomycinbystrainsofsalmonellatyphimuriumescherichiacoliandhaemophilusinfluenzae |