Liver Regeneration as a Model for Studying Cellular Plasticity in Mammals: The Roles of Hepatocytes and Cholangiocytes
In most countries, liver disease is one of the most common pathologic conditions among the population. In this regard, the development of new methods to treat liver diseases is not possible without understanding the mechanisms of regeneration of this organ. A characteristic reaction of the liver to...
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MDPI AG
2025-07-01
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| author | Andrey Elchaninov Polina Vishnyakova Valeria Glinkina Timur Fatkhudinov Gennady Sukhikh |
| author_facet | Andrey Elchaninov Polina Vishnyakova Valeria Glinkina Timur Fatkhudinov Gennady Sukhikh |
| author_sort | Andrey Elchaninov |
| collection | DOAJ |
| description | In most countries, liver disease is one of the most common pathologic conditions among the population. In this regard, the development of new methods to treat liver diseases is not possible without understanding the mechanisms of regeneration of this organ. A characteristic reaction of the liver to certain damaging factors is a pronounced cellular plasticity; this primarily concerns hepatocytes and cholangiocytes. This property is also characteristic of Ito stellate cells and macrophages. In this study, we focus on the plasticity of hepatocytes and cholangiocytes. We consider such manifestations of plasticity as the ability to enter the mitotic cycle, as well as transdifferentiation. The contribution of each type of plasticity to liver regeneration is considered, as well as the molecular mechanisms providing the cellular plasticity of hepatocytes and cholangiocytes. |
| format | Article |
| id | doaj-art-e64730bef092424a8fa38533409846c6 |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-e64730bef092424a8fa38533409846c62025-08-20T04:00:54ZengMDPI AGCells2073-44092025-07-011415112910.3390/cells14151129Liver Regeneration as a Model for Studying Cellular Plasticity in Mammals: The Roles of Hepatocytes and CholangiocytesAndrey Elchaninov0Polina Vishnyakova1Valeria Glinkina2Timur Fatkhudinov3Gennady Sukhikh4Laboratory of Growth and Development, Avtsyn Research Institute of Human Morphology of FSBI “Petrovsky National Research Centre of Surgery”, 3 Tsurupa Street, 117418 Moscow, RussiaLaboratory of Molecular Pathophysiology, Research Institute of Molecular and Cellular Medicine, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, RussiaLaboratory of Molecular Pathophysiology, Research Institute of Molecular and Cellular Medicine, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, RussiaLaboratory of Growth and Development, Avtsyn Research Institute of Human Morphology of FSBI “Petrovsky National Research Centre of Surgery”, 3 Tsurupa Street, 117418 Moscow, RussiaLaboratory of Regenerative Medicine, Institute of Translational Medicine, National Medical Research Centre for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, 117997 Moscow, RussiaIn most countries, liver disease is one of the most common pathologic conditions among the population. In this regard, the development of new methods to treat liver diseases is not possible without understanding the mechanisms of regeneration of this organ. A characteristic reaction of the liver to certain damaging factors is a pronounced cellular plasticity; this primarily concerns hepatocytes and cholangiocytes. This property is also characteristic of Ito stellate cells and macrophages. In this study, we focus on the plasticity of hepatocytes and cholangiocytes. We consider such manifestations of plasticity as the ability to enter the mitotic cycle, as well as transdifferentiation. The contribution of each type of plasticity to liver regeneration is considered, as well as the molecular mechanisms providing the cellular plasticity of hepatocytes and cholangiocytes.https://www.mdpi.com/2073-4409/14/15/1129liverregenerationhepatocytescholangiocytescell plasticity |
| spellingShingle | Andrey Elchaninov Polina Vishnyakova Valeria Glinkina Timur Fatkhudinov Gennady Sukhikh Liver Regeneration as a Model for Studying Cellular Plasticity in Mammals: The Roles of Hepatocytes and Cholangiocytes Cells liver regeneration hepatocytes cholangiocytes cell plasticity |
| title | Liver Regeneration as a Model for Studying Cellular Plasticity in Mammals: The Roles of Hepatocytes and Cholangiocytes |
| title_full | Liver Regeneration as a Model for Studying Cellular Plasticity in Mammals: The Roles of Hepatocytes and Cholangiocytes |
| title_fullStr | Liver Regeneration as a Model for Studying Cellular Plasticity in Mammals: The Roles of Hepatocytes and Cholangiocytes |
| title_full_unstemmed | Liver Regeneration as a Model for Studying Cellular Plasticity in Mammals: The Roles of Hepatocytes and Cholangiocytes |
| title_short | Liver Regeneration as a Model for Studying Cellular Plasticity in Mammals: The Roles of Hepatocytes and Cholangiocytes |
| title_sort | liver regeneration as a model for studying cellular plasticity in mammals the roles of hepatocytes and cholangiocytes |
| topic | liver regeneration hepatocytes cholangiocytes cell plasticity |
| url | https://www.mdpi.com/2073-4409/14/15/1129 |
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