Evolutionary history of magnoliid genomes and benzylisoquinoline alkaloid biosynthesis
Abstract Benzylisoquinoline alkaloids (BIAs) are important metabolites synthesized in early-diverging eudicots and magnoliids, yet the genetic basis of BIA biosynthesis in magnoliids remains unclear. Here, we decode the genomes of two magnoliid species, Saruma henryi and Aristolochia manshuriensis,...
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Nature Portfolio
2025-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-59343-8 |
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| author | Yiheng Hu Jinpeng Wang Lumei Liu Xin Yi Xin Wang Jianyu Wang Ya’nan Hao Liuyu Qin Kunpeng Li Yishan Feng Zhongshuai Zhang Hanying Wu Yuannian Jiao |
| author_facet | Yiheng Hu Jinpeng Wang Lumei Liu Xin Yi Xin Wang Jianyu Wang Ya’nan Hao Liuyu Qin Kunpeng Li Yishan Feng Zhongshuai Zhang Hanying Wu Yuannian Jiao |
| author_sort | Yiheng Hu |
| collection | DOAJ |
| description | Abstract Benzylisoquinoline alkaloids (BIAs) are important metabolites synthesized in early-diverging eudicots and magnoliids, yet the genetic basis of BIA biosynthesis in magnoliids remains unclear. Here, we decode the genomes of two magnoliid species, Saruma henryi and Aristolochia manshuriensis, and reconstruct the ancestral magnoliid karyotype and infer the chromosomal rearrangement history following magnoliid diversification. Metabolomic, transcriptomic, and phylogenetic analyses reveal the intermediate chemical components and genetic basis of BIA biosynthesis in A. manshuriensis. Although the core enzymes involved in BIA synthesis appear to be largely conserved between early-diverging eudicots and magnoliids, the biosynthetic pathways in magnoliids seem to exhibit greater flexibility. Significantly, our investigation of the evolutionary history of BIA biosynthetic genes revealed that almost all were duplicated before the emergence of extant angiosperms, with only early-diverging eudicots and magnoliids preferentially retaining these duplicated genes, thereby enabling the biosynthesis of BIAs in these groups. |
| format | Article |
| id | doaj-art-e63eb72fcc8e439883a6fe06587b55f9 |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-e63eb72fcc8e439883a6fe06587b55f92025-08-20T02:55:23ZengNature PortfolioNature Communications2041-17232025-04-0116111810.1038/s41467-025-59343-8Evolutionary history of magnoliid genomes and benzylisoquinoline alkaloid biosynthesisYiheng Hu0Jinpeng Wang1Lumei Liu2Xin Yi3Xin Wang4Jianyu Wang5Ya’nan Hao6Liuyu Qin7Kunpeng Li8Yishan Feng9Zhongshuai Zhang10Hanying Wu11Yuannian Jiao12State Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of SciencesState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of SciencesState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of SciencesState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of SciencesState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of SciencesState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of SciencesDepartment of Bioinformatics, School of Life Sciences, North China University of Science and TechnologyState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of SciencesState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of SciencesDepartment of Bioinformatics, School of Life Sciences, North China University of Science and TechnologyState Key Laboratory of Tree Genetics and Breeding, Chinese Academy of ForestryKey Laboratory of Systematic and Evolutionary Botany, Institute of Botany, the Chinese Academy of SciencesState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of SciencesAbstract Benzylisoquinoline alkaloids (BIAs) are important metabolites synthesized in early-diverging eudicots and magnoliids, yet the genetic basis of BIA biosynthesis in magnoliids remains unclear. Here, we decode the genomes of two magnoliid species, Saruma henryi and Aristolochia manshuriensis, and reconstruct the ancestral magnoliid karyotype and infer the chromosomal rearrangement history following magnoliid diversification. Metabolomic, transcriptomic, and phylogenetic analyses reveal the intermediate chemical components and genetic basis of BIA biosynthesis in A. manshuriensis. Although the core enzymes involved in BIA synthesis appear to be largely conserved between early-diverging eudicots and magnoliids, the biosynthetic pathways in magnoliids seem to exhibit greater flexibility. Significantly, our investigation of the evolutionary history of BIA biosynthetic genes revealed that almost all were duplicated before the emergence of extant angiosperms, with only early-diverging eudicots and magnoliids preferentially retaining these duplicated genes, thereby enabling the biosynthesis of BIAs in these groups.https://doi.org/10.1038/s41467-025-59343-8 |
| spellingShingle | Yiheng Hu Jinpeng Wang Lumei Liu Xin Yi Xin Wang Jianyu Wang Ya’nan Hao Liuyu Qin Kunpeng Li Yishan Feng Zhongshuai Zhang Hanying Wu Yuannian Jiao Evolutionary history of magnoliid genomes and benzylisoquinoline alkaloid biosynthesis Nature Communications |
| title | Evolutionary history of magnoliid genomes and benzylisoquinoline alkaloid biosynthesis |
| title_full | Evolutionary history of magnoliid genomes and benzylisoquinoline alkaloid biosynthesis |
| title_fullStr | Evolutionary history of magnoliid genomes and benzylisoquinoline alkaloid biosynthesis |
| title_full_unstemmed | Evolutionary history of magnoliid genomes and benzylisoquinoline alkaloid biosynthesis |
| title_short | Evolutionary history of magnoliid genomes and benzylisoquinoline alkaloid biosynthesis |
| title_sort | evolutionary history of magnoliid genomes and benzylisoquinoline alkaloid biosynthesis |
| url | https://doi.org/10.1038/s41467-025-59343-8 |
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