Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies
The tumor immune microenvironment (TIME) represents a complex battlefield where metabolic competition and immune evasion mechanisms converge to drive cancer progression. Amino acids, with their multifaceted biological roles, have emerged as pivotal regulators of tumor cell proliferation and immune c...
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| Format: | Article |
| Language: | English |
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China Anti-Cancer Association
2025-07-01
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| Series: | Cancer Biology & Medicine |
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| Online Access: | https://www.cancerbiomed.org/content/22/7/726 |
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| _version_ | 1849245414565347328 |
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| author | Ziyou Lin Chang Chang Shuyu Zhao Lan Fang Ping Wang |
| author_facet | Ziyou Lin Chang Chang Shuyu Zhao Lan Fang Ping Wang |
| author_sort | Ziyou Lin |
| collection | DOAJ |
| description | The tumor immune microenvironment (TIME) represents a complex battlefield where metabolic competition and immune evasion mechanisms converge to drive cancer progression. Amino acids, with their multifaceted biological roles, have emerged as pivotal regulators of tumor cell proliferation and immune cell functionality. The sensing mechanisms by which amino acids within the tumor microenvironment influence cellular growth, survival, and immune function are systematically explored in this review; the latest advances in understanding amino acid metabolism in tumor biology are also reviewed. In addition, the multifaceted roles of key amino acids in shaping the TIME with particular emphasis on tumor immunity and malignant growth were investigated. Finally, emerging therapeutic strategies targeting amino acid metabolism to reprogram the TIME are discussed, highlighting promising approaches, such as CAR-T cell therapy and engineered bacterial interventions. Through this comprehensive analysis, critical insights into future research directions and potential clinical translation of amino acid-targeted interventions are provided. |
| format | Article |
| id | doaj-art-e63d3e61059f46d083829304a1ed98d6 |
| institution | Kabale University |
| issn | 2095-3941 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj-art-e63d3e61059f46d083829304a1ed98d62025-08-20T03:58:49ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412025-07-0122772674610.20892/j.issn.2095-3941.2025.0115Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategiesZiyou Lin0Chang Chang1Shuyu Zhao2Lan Fang3Ping Wang4Tongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaTongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaTongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaTongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaTongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaThe tumor immune microenvironment (TIME) represents a complex battlefield where metabolic competition and immune evasion mechanisms converge to drive cancer progression. Amino acids, with their multifaceted biological roles, have emerged as pivotal regulators of tumor cell proliferation and immune cell functionality. The sensing mechanisms by which amino acids within the tumor microenvironment influence cellular growth, survival, and immune function are systematically explored in this review; the latest advances in understanding amino acid metabolism in tumor biology are also reviewed. In addition, the multifaceted roles of key amino acids in shaping the TIME with particular emphasis on tumor immunity and malignant growth were investigated. Finally, emerging therapeutic strategies targeting amino acid metabolism to reprogram the TIME are discussed, highlighting promising approaches, such as CAR-T cell therapy and engineered bacterial interventions. Through this comprehensive analysis, critical insights into future research directions and potential clinical translation of amino acid-targeted interventions are provided.https://www.cancerbiomed.org/content/22/7/726tumor microenvironment (tme)amino acid sensingamino acid metabolismmetabolic reprogrammingimmunotherapy |
| spellingShingle | Ziyou Lin Chang Chang Shuyu Zhao Lan Fang Ping Wang Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies Cancer Biology & Medicine tumor microenvironment (tme) amino acid sensing amino acid metabolism metabolic reprogramming immunotherapy |
| title | Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies |
| title_full | Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies |
| title_fullStr | Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies |
| title_full_unstemmed | Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies |
| title_short | Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies |
| title_sort | amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment from molecular mechanisms to therapeutic strategies |
| topic | tumor microenvironment (tme) amino acid sensing amino acid metabolism metabolic reprogramming immunotherapy |
| url | https://www.cancerbiomed.org/content/22/7/726 |
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