Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile.
Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and disease prevention. Here we investigate possible associations between the type o...
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Public Library of Science (PLoS)
2017-05-01
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| Series: | PLoS Genetics |
| Online Access: | https://doi.org/10.1371/journal.pgen.1006756 |
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| author | Justo Lorenzo Bermejo Felix Boekstegers Rosa González Silos Katherine Marcelain Pablo Baez Benavides Carol Barahona Ponce Bettina Müller Catterina Ferreccio Jill Koshiol Christine Fischer Barbara Peil Janet Sinsheimer Macarena Fuentes Guajardo Olga Barajas Rolando Gonzalez-Jose Gabriel Bedoya Maria Cátira Bortolini Samuel Canizales-Quinteros Carla Gallo Andres Ruiz Linares Francisco Rothhammer |
| author_facet | Justo Lorenzo Bermejo Felix Boekstegers Rosa González Silos Katherine Marcelain Pablo Baez Benavides Carol Barahona Ponce Bettina Müller Catterina Ferreccio Jill Koshiol Christine Fischer Barbara Peil Janet Sinsheimer Macarena Fuentes Guajardo Olga Barajas Rolando Gonzalez-Jose Gabriel Bedoya Maria Cátira Bortolini Samuel Canizales-Quinteros Carla Gallo Andres Ruiz Linares Francisco Rothhammer |
| author_sort | Justo Lorenzo Bermejo |
| collection | DOAJ |
| description | Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and disease prevention. Here we investigate possible associations between the type of Native American ancestry and leading causes of death. After an aggregate-data study based on genome-wide genotype data from 1805 admixed Chileans and 639,789 deaths, we validate an identified association with gallbladder cancer relying on individual data from 64 gallbladder cancer patients, with and without a family history, and 170 healthy controls. Native American proportions were markedly underestimated when the two main types of Native American ancestry in Chile, originated from the Mapuche and Aymara indigenous peoples, were combined together. Consideration of the type of Native American ancestry was crucial to identify disease associations. Native American ancestry showed no association with gallbladder cancer mortality (P = 0.26). By contrast, each 1% increase in the Mapuche proportion represented a 3.7% increased mortality risk by gallbladder cancer (95%CI 3.1-4.3%, P = 6×10-27). Individual-data results and extensive sensitivity analyses confirmed the association between Mapuche ancestry and gallbladder cancer. Increasing Mapuche proportions were also associated with an increased mortality due to asthma and, interestingly, with a decreased mortality by diabetes. The mortality due to skin, bladder, larynx, bronchus and lung cancers increased with increasing Aymara proportions. Described methods should be considered in future studies on human population genetics and human health. Complementary individual-based studies are needed to apportion the genetic and non-genetic components of associations identified relying on aggregate-data. |
| format | Article |
| id | doaj-art-e63cd4e21a514f0eb39266928fc9248d |
| institution | OA Journals |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-e63cd4e21a514f0eb39266928fc9248d2025-08-20T02:22:06ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042017-05-01135e100675610.1371/journal.pgen.1006756Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile.Justo Lorenzo BermejoFelix BoekstegersRosa González SilosKatherine MarcelainPablo Baez BenavidesCarol Barahona PonceBettina MüllerCatterina FerreccioJill KoshiolChristine FischerBarbara PeilJanet SinsheimerMacarena Fuentes GuajardoOlga BarajasRolando Gonzalez-JoseGabriel BedoyaMaria Cátira BortoliniSamuel Canizales-QuinterosCarla GalloAndres Ruiz LinaresFrancisco RothhammerLatin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and disease prevention. Here we investigate possible associations between the type of Native American ancestry and leading causes of death. After an aggregate-data study based on genome-wide genotype data from 1805 admixed Chileans and 639,789 deaths, we validate an identified association with gallbladder cancer relying on individual data from 64 gallbladder cancer patients, with and without a family history, and 170 healthy controls. Native American proportions were markedly underestimated when the two main types of Native American ancestry in Chile, originated from the Mapuche and Aymara indigenous peoples, were combined together. Consideration of the type of Native American ancestry was crucial to identify disease associations. Native American ancestry showed no association with gallbladder cancer mortality (P = 0.26). By contrast, each 1% increase in the Mapuche proportion represented a 3.7% increased mortality risk by gallbladder cancer (95%CI 3.1-4.3%, P = 6×10-27). Individual-data results and extensive sensitivity analyses confirmed the association between Mapuche ancestry and gallbladder cancer. Increasing Mapuche proportions were also associated with an increased mortality due to asthma and, interestingly, with a decreased mortality by diabetes. The mortality due to skin, bladder, larynx, bronchus and lung cancers increased with increasing Aymara proportions. Described methods should be considered in future studies on human population genetics and human health. Complementary individual-based studies are needed to apportion the genetic and non-genetic components of associations identified relying on aggregate-data.https://doi.org/10.1371/journal.pgen.1006756 |
| spellingShingle | Justo Lorenzo Bermejo Felix Boekstegers Rosa González Silos Katherine Marcelain Pablo Baez Benavides Carol Barahona Ponce Bettina Müller Catterina Ferreccio Jill Koshiol Christine Fischer Barbara Peil Janet Sinsheimer Macarena Fuentes Guajardo Olga Barajas Rolando Gonzalez-Jose Gabriel Bedoya Maria Cátira Bortolini Samuel Canizales-Quinteros Carla Gallo Andres Ruiz Linares Francisco Rothhammer Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile. PLoS Genetics |
| title | Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile. |
| title_full | Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile. |
| title_fullStr | Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile. |
| title_full_unstemmed | Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile. |
| title_short | Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile. |
| title_sort | subtypes of native american ancestry and leading causes of death mapuche ancestry specific associations with gallbladder cancer risk in chile |
| url | https://doi.org/10.1371/journal.pgen.1006756 |
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