The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside
In principle, induced pluripotent stem cells (iPSCs) are generated from somatic cells by reprogramming and gaining the capacity to self-renew indefinitely as well as the ability to differentiate into cells of different lineages. Human iPSCs have absolute advantages over human embryonic stem cells (E...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/6484713 |
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| author | Nina Xie Beisha Tang |
| author_facet | Nina Xie Beisha Tang |
| author_sort | Nina Xie |
| collection | DOAJ |
| description | In principle, induced pluripotent stem cells (iPSCs) are generated from somatic cells by reprogramming and gaining the capacity to self-renew indefinitely as well as the ability to differentiate into cells of different lineages. Human iPSCs have absolute advantages over human embryonic stem cells (ESCs) and animal models in disease modeling, drug screening, and cell replacement therapy. Since Takahashi and Yamanaka first described in 2007 that iPSCs can be generated from human adult somatic cells by retroviral transduction of the four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc, disease specific iPSC lines have sprung up worldwide like bamboo shoots after a spring rain, making iPSC one of the hottest and fastest moving topics in modern science. The craze for iPSCs has spread throughout main branches of clinical medicine, covering neurology, hematology, cardiology, endocrinology, hepatology, ophthalmology, and so on. Here in this paper, we will focus on the clinical application of human iPSCs in disease modeling, drug screening, and cell replacement therapy for neurological diseases. |
| format | Article |
| id | doaj-art-e63c21a49ebe49468fad25e472e299d2 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-e63c21a49ebe49468fad25e472e299d22025-08-20T03:26:04ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/64847136484713The Application of Human iPSCs in Neurological Diseases: From Bench to BedsideNina Xie0Beisha Tang1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaIn principle, induced pluripotent stem cells (iPSCs) are generated from somatic cells by reprogramming and gaining the capacity to self-renew indefinitely as well as the ability to differentiate into cells of different lineages. Human iPSCs have absolute advantages over human embryonic stem cells (ESCs) and animal models in disease modeling, drug screening, and cell replacement therapy. Since Takahashi and Yamanaka first described in 2007 that iPSCs can be generated from human adult somatic cells by retroviral transduction of the four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc, disease specific iPSC lines have sprung up worldwide like bamboo shoots after a spring rain, making iPSC one of the hottest and fastest moving topics in modern science. The craze for iPSCs has spread throughout main branches of clinical medicine, covering neurology, hematology, cardiology, endocrinology, hepatology, ophthalmology, and so on. Here in this paper, we will focus on the clinical application of human iPSCs in disease modeling, drug screening, and cell replacement therapy for neurological diseases.http://dx.doi.org/10.1155/2016/6484713 |
| spellingShingle | Nina Xie Beisha Tang The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside Stem Cells International |
| title | The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside |
| title_full | The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside |
| title_fullStr | The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside |
| title_full_unstemmed | The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside |
| title_short | The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside |
| title_sort | application of human ipscs in neurological diseases from bench to bedside |
| url | http://dx.doi.org/10.1155/2016/6484713 |
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