Comparative study on government subsidy models for competitive drug supply chains under centralized procurement policy

As the generic drug market tends to be saturated, the structural transformation of generic drug companies is imminent, while the high investment and high-risk attributes of innovative drug research and development aggravate the transformation difficulties. Against the backdrop of drug centralized pr...

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Main Authors: Yan Wen, Yan Wei, Lu Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Public Health
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fpubh.2025.1542858/full
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author Yan Wen
Yan Wei
Lu Liu
author_facet Yan Wen
Yan Wei
Lu Liu
author_sort Yan Wen
collection DOAJ
description As the generic drug market tends to be saturated, the structural transformation of generic drug companies is imminent, while the high investment and high-risk attributes of innovative drug research and development aggravate the transformation difficulties. Against the backdrop of drug centralized procurement policy, considering the effect of health insurance reimbursement and market competition ferocity, this study constructs a differential game model of a secondary drug supply chain comprising two competing drug companies and a single healthcare institution. In addition, this study comparatively analyzes the optimal equilibrium strategies and supply chain profit levels of drug research and development investment and healthcare service efforts under four government subsidy modes, further discussing them along with arithmetic examples. It is found that the government's subsidy behavior markedly influenced drug companies' investment in drug research and development and healthcare institution' service cost investment. Besides, different incentives for supply chain members' decision-making and profits were noted in different markets with different competition intensities. In the low-intensity competition market, the government's subsidies to innovative drug companies generate much higher social welfare than other modes. In the high-intensity competition market, the government subsidized healthcare institution can minimize the mutually exclusive effects of subsidies on the development of innovative and generic drug companies, and eventually drive the reform and development of the entire drug industry.
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spelling doaj-art-e637e15ce5074f6884afe9357f4822c52025-08-20T02:52:58ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-03-011310.3389/fpubh.2025.15428581542858Comparative study on government subsidy models for competitive drug supply chains under centralized procurement policyYan WenYan WeiLu LiuAs the generic drug market tends to be saturated, the structural transformation of generic drug companies is imminent, while the high investment and high-risk attributes of innovative drug research and development aggravate the transformation difficulties. Against the backdrop of drug centralized procurement policy, considering the effect of health insurance reimbursement and market competition ferocity, this study constructs a differential game model of a secondary drug supply chain comprising two competing drug companies and a single healthcare institution. In addition, this study comparatively analyzes the optimal equilibrium strategies and supply chain profit levels of drug research and development investment and healthcare service efforts under four government subsidy modes, further discussing them along with arithmetic examples. It is found that the government's subsidy behavior markedly influenced drug companies' investment in drug research and development and healthcare institution' service cost investment. Besides, different incentives for supply chain members' decision-making and profits were noted in different markets with different competition intensities. In the low-intensity competition market, the government's subsidies to innovative drug companies generate much higher social welfare than other modes. In the high-intensity competition market, the government subsidized healthcare institution can minimize the mutually exclusive effects of subsidies on the development of innovative and generic drug companies, and eventually drive the reform and development of the entire drug industry.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1542858/fullcentralized procurementgovernment subsidiesdifferential gamedrug supply chaininnovative drug
spellingShingle Yan Wen
Yan Wei
Lu Liu
Comparative study on government subsidy models for competitive drug supply chains under centralized procurement policy
Frontiers in Public Health
centralized procurement
government subsidies
differential game
drug supply chain
innovative drug
title Comparative study on government subsidy models for competitive drug supply chains under centralized procurement policy
title_full Comparative study on government subsidy models for competitive drug supply chains under centralized procurement policy
title_fullStr Comparative study on government subsidy models for competitive drug supply chains under centralized procurement policy
title_full_unstemmed Comparative study on government subsidy models for competitive drug supply chains under centralized procurement policy
title_short Comparative study on government subsidy models for competitive drug supply chains under centralized procurement policy
title_sort comparative study on government subsidy models for competitive drug supply chains under centralized procurement policy
topic centralized procurement
government subsidies
differential game
drug supply chain
innovative drug
url https://www.frontiersin.org/articles/10.3389/fpubh.2025.1542858/full
work_keys_str_mv AT yanwen comparativestudyongovernmentsubsidymodelsforcompetitivedrugsupplychainsundercentralizedprocurementpolicy
AT yanwei comparativestudyongovernmentsubsidymodelsforcompetitivedrugsupplychainsundercentralizedprocurementpolicy
AT luliu comparativestudyongovernmentsubsidymodelsforcompetitivedrugsupplychainsundercentralizedprocurementpolicy