Severe Thrombocytopenic Purpura in a Child with Brucellosis: Case Presentation and Review of the Literature
Brucellosis is still endemic and a significant public health problem in many Mediterranean countries, including Greece. It is a multisystemic disease with a broad spectrum of clinical manifestations including hematological disorders, such as anemia, pancytopenia, leucopenia, and thrombocytopenia. Th...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2017/3416857 |
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| author | Alexandros Makis Aikaterini Perogiannaki Nikolaos Chaliasos |
| author_facet | Alexandros Makis Aikaterini Perogiannaki Nikolaos Chaliasos |
| author_sort | Alexandros Makis |
| collection | DOAJ |
| description | Brucellosis is still endemic and a significant public health problem in many Mediterranean countries, including Greece. It is a multisystemic disease with a broad spectrum of clinical manifestations including hematological disorders, such as anemia, pancytopenia, leucopenia, and thrombocytopenia. Thrombocytopenia is usually moderate and attributed to bone marrow suppression or hypersplenism. Rarely, autoimmune stimulation can cause severe thrombocytopenia with clinically significant hemorrhagic manifestations. We present the case of a girl with severe thrombocytopenic purpura as one of the presenting symptoms of Brucella melitensis infection. Treatment with intravenous immunoglobulin and the appropriate antimicrobial agents promptly resolved the thrombocyte counts. A review of similar published cases is also presented. |
| format | Article |
| id | doaj-art-e637436e30eb4f2db4457811ca6ffe05 |
| institution | OA Journals |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-e637436e30eb4f2db4457811ca6ffe052025-08-20T02:21:02ZengWileyCase Reports in Infectious Diseases2090-66252090-66332017-01-01201710.1155/2017/34168573416857Severe Thrombocytopenic Purpura in a Child with Brucellosis: Case Presentation and Review of the LiteratureAlexandros Makis0Aikaterini Perogiannaki1Nikolaos Chaliasos2Child Health Department, Faculty of Medicine, University of Ioannina, Ioannina, GreeceChild Health Department, Faculty of Medicine, University of Ioannina, Ioannina, GreeceChild Health Department, Faculty of Medicine, University of Ioannina, Ioannina, GreeceBrucellosis is still endemic and a significant public health problem in many Mediterranean countries, including Greece. It is a multisystemic disease with a broad spectrum of clinical manifestations including hematological disorders, such as anemia, pancytopenia, leucopenia, and thrombocytopenia. Thrombocytopenia is usually moderate and attributed to bone marrow suppression or hypersplenism. Rarely, autoimmune stimulation can cause severe thrombocytopenia with clinically significant hemorrhagic manifestations. We present the case of a girl with severe thrombocytopenic purpura as one of the presenting symptoms of Brucella melitensis infection. Treatment with intravenous immunoglobulin and the appropriate antimicrobial agents promptly resolved the thrombocyte counts. A review of similar published cases is also presented.http://dx.doi.org/10.1155/2017/3416857 |
| spellingShingle | Alexandros Makis Aikaterini Perogiannaki Nikolaos Chaliasos Severe Thrombocytopenic Purpura in a Child with Brucellosis: Case Presentation and Review of the Literature Case Reports in Infectious Diseases |
| title | Severe Thrombocytopenic Purpura in a Child with Brucellosis: Case Presentation and Review of the Literature |
| title_full | Severe Thrombocytopenic Purpura in a Child with Brucellosis: Case Presentation and Review of the Literature |
| title_fullStr | Severe Thrombocytopenic Purpura in a Child with Brucellosis: Case Presentation and Review of the Literature |
| title_full_unstemmed | Severe Thrombocytopenic Purpura in a Child with Brucellosis: Case Presentation and Review of the Literature |
| title_short | Severe Thrombocytopenic Purpura in a Child with Brucellosis: Case Presentation and Review of the Literature |
| title_sort | severe thrombocytopenic purpura in a child with brucellosis case presentation and review of the literature |
| url | http://dx.doi.org/10.1155/2017/3416857 |
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