Complement pathway: Risk molecular pattern of cardiovascular diseases in patients with diabetic nephropathy
Background: Among individuals with diabetes mellitus, diabetic nephropathy (DN) is a common microvascular complication. As renal dysfunction progresses in DN patients, the risk of cardiovascular disease (CVD) significantly increases. The current effective treatment of DN and CVD demands identifying...
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Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582504801L.pdf |
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| author | Liu JunFei Qian XiaoPing Wang TaoXia Liu XiaoLi Liu WeiGang Wang LiJie Zhang HuiFang Han Li Li GuiYing Yu XiaoJuan |
| author_facet | Liu JunFei Qian XiaoPing Wang TaoXia Liu XiaoLi Liu WeiGang Wang LiJie Zhang HuiFang Han Li Li GuiYing Yu XiaoJuan |
| author_sort | Liu JunFei |
| collection | DOAJ |
| description | Background: Among individuals with diabetes mellitus, diabetic nephropathy (DN) is a common microvascular complication. As renal dysfunction progresses in DN patients, the risk of cardiovascular disease (CVD) significantly increases. The current effective treatment of DN and CVD demands identifying and managing their risk factors. Methods: Patients diagnosed with DN from October 2022 to October 2023 were selected for cross-sectional study and divided into DN group (n=58) and DN/CVD group (n=40) based on the presence of CVD. Univariate analysis was conducted using clinical data, and statistically significant independent variables were analysed through multivariate Logistic regression to identify independent factors influencing CVD in DN patients. A regression model was developed to examine the non-linear relationship between C1q, UA, CRP, and the risk of CVD. The receiver operating characteristic curve was used to analyse the predictive efficacy of the indicators. Results: When elevated, UA and C1q were independent factors for CVD. A linear relationship existed between UA and C1q and the risk of CVD in DN patients. C1q showed better predictive performance. Conclusions: As UA and C1q levels rise, the risk of CVD in DN patients significantly increases. In DN patients, UA and C1q are associated with CVD development and progression, offering some supportive evaluation value for the patient's condition. |
| format | Article |
| id | doaj-art-e634b7cf8439483f8e6d00208b83f603 |
| institution | DOAJ |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj-art-e634b7cf8439483f8e6d00208b83f6032025-08-20T02:44:38ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-0144480180710.5937/jomb0-562211452-82582504801LComplement pathway: Risk molecular pattern of cardiovascular diseases in patients with diabetic nephropathyLiu JunFei0Qian XiaoPing1Wang TaoXia2Liu XiaoLi3Liu WeiGang4Wang LiJie5Zhang HuiFang6Han Li7Li GuiYing8Yu XiaoJuan9Affiliated Hospital of Hebei University of Engineering, Department of Nephrology, The Key Laboratory of Basic Research on Blood Purification Application in Hebei Province, Handan City, Hebei Province, ChinaAffiliated Hospital of Hebei University of Engineering, Department of Nephrology, The Key Laboratory of Basic Research on Blood Purification Application in Hebei Province, Handan City, Hebei Province, ChinaAffiliated Hospital of Hebei University of Engineering, Department of Nephrology, The Key Laboratory of Basic Research on Blood Purification Application in Hebei Province, Handan City, Hebei Province, ChinaAffiliated Hospital of Hebei University of Engineering, Department of Nephrology, The Key Laboratory of Basic Research on Blood Purification Application in Hebei Province, Handan City, Hebei Province, ChinaAffiliated Hospital of Hebei University of Engineering, Department of Nephrology, The Key Laboratory of Basic Research on Blood Purification Application in Hebei Province, Handan City, Hebei Province, ChinaAffiliated Hospital of Hebei University of Engineering, Department of Nephrology, The Key Laboratory of Basic Research on Blood Purification Application in Hebei Province, Handan City, Hebei Province, ChinaAffiliated Hospital of Hebei University of Engineering, Department of Nephrology, The Key Laboratory of Basic Research on Blood Purification Application in Hebei Province, Handan City, Hebei Province, ChinaAffiliated Hospital of Hebei University of Engineering, Department of Nephrology, The Key Laboratory of Basic Research on Blood Purification Application in Hebei Province, Handan City, Hebei Province, ChinaAffiliated Hospital of Hebei University of Engineering, Department of Nephrology, The Key Laboratory of Basic Research on Blood Purification Application in Hebei Province, Handan City, Hebei Province, ChinaAffiliated Hospital of Hebei University of Engineering, Department of Nutrition, Handan City, Hebei Province, ChinaBackground: Among individuals with diabetes mellitus, diabetic nephropathy (DN) is a common microvascular complication. As renal dysfunction progresses in DN patients, the risk of cardiovascular disease (CVD) significantly increases. The current effective treatment of DN and CVD demands identifying and managing their risk factors. Methods: Patients diagnosed with DN from October 2022 to October 2023 were selected for cross-sectional study and divided into DN group (n=58) and DN/CVD group (n=40) based on the presence of CVD. Univariate analysis was conducted using clinical data, and statistically significant independent variables were analysed through multivariate Logistic regression to identify independent factors influencing CVD in DN patients. A regression model was developed to examine the non-linear relationship between C1q, UA, CRP, and the risk of CVD. The receiver operating characteristic curve was used to analyse the predictive efficacy of the indicators. Results: When elevated, UA and C1q were independent factors for CVD. A linear relationship existed between UA and C1q and the risk of CVD in DN patients. C1q showed better predictive performance. Conclusions: As UA and C1q levels rise, the risk of CVD in DN patients significantly increases. In DN patients, UA and C1q are associated with CVD development and progression, offering some supportive evaluation value for the patient's condition.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582504801L.pdfcomplement pathwaydiabetic nephropathycardiovascular eventscomplications |
| spellingShingle | Liu JunFei Qian XiaoPing Wang TaoXia Liu XiaoLi Liu WeiGang Wang LiJie Zhang HuiFang Han Li Li GuiYing Yu XiaoJuan Complement pathway: Risk molecular pattern of cardiovascular diseases in patients with diabetic nephropathy Journal of Medical Biochemistry complement pathway diabetic nephropathy cardiovascular events complications |
| title | Complement pathway: Risk molecular pattern of cardiovascular diseases in patients with diabetic nephropathy |
| title_full | Complement pathway: Risk molecular pattern of cardiovascular diseases in patients with diabetic nephropathy |
| title_fullStr | Complement pathway: Risk molecular pattern of cardiovascular diseases in patients with diabetic nephropathy |
| title_full_unstemmed | Complement pathway: Risk molecular pattern of cardiovascular diseases in patients with diabetic nephropathy |
| title_short | Complement pathway: Risk molecular pattern of cardiovascular diseases in patients with diabetic nephropathy |
| title_sort | complement pathway risk molecular pattern of cardiovascular diseases in patients with diabetic nephropathy |
| topic | complement pathway diabetic nephropathy cardiovascular events complications |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582504801L.pdf |
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