Helminths: Immunoregulation and Inflammatory Diseases—Which Side Are Trichinella spp. and Toxocara spp. on?
Macropathogens, such as multicellular helminths, are considered masters of immunoregulation due to their ability to escape host defense and establish chronic infections. Molecular crosstalk between the host and the parasite starts immediately after their encounter, which influences the course and de...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2013/329438 |
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| author | Carmen Aranzamendi Ljiljana Sofronic-Milosavljevic Elena Pinelli |
| author_facet | Carmen Aranzamendi Ljiljana Sofronic-Milosavljevic Elena Pinelli |
| author_sort | Carmen Aranzamendi |
| collection | DOAJ |
| description | Macropathogens, such as multicellular helminths, are considered masters of immunoregulation due to their ability to escape host defense and establish chronic infections. Molecular crosstalk between the host and the parasite starts immediately after their encounter, which influences the course and development of both the innate and adaptive arms of the immune response. Helminths can modulate dendritic cells (DCs) function and induce immunosuppression which is mediated by a regulatory network that includes regulatory T (Treg) cells, regulatory B (Breg) cells, and alternatively activated macrophages (AAMs). In this way, helminths suppress and control both parasite-specific and unrelated immunopathology in the host such as Th1-mediated autoimmune and Th2-mediated allergic diseases. However, certain helminths favour the development or exacerbation of allergic responses. In this paper, the cell types that play an essential role in helminth-induced immunoregulation, the consequences for inflammatory diseases, and the contrasting effects of Toxocara and Trichinella infection on allergic manifestations are discussed. |
| format | Article |
| id | doaj-art-e62e6a17a1914bba90044edd5a337a53 |
| institution | OA Journals |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-e62e6a17a1914bba90044edd5a337a532025-08-20T02:21:02ZengWileyJournal of Parasitology Research2090-00232090-00312013-01-01201310.1155/2013/329438329438Helminths: Immunoregulation and Inflammatory Diseases—Which Side Are Trichinella spp. and Toxocara spp. on?Carmen Aranzamendi0Ljiljana Sofronic-Milosavljevic1Elena Pinelli2Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The NetherlandsInstitute for the Application of Nuclear Energy (INEP), University of Belgrade, Banatska 31b, 11080 Belgrade, SerbiaCentre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The NetherlandsMacropathogens, such as multicellular helminths, are considered masters of immunoregulation due to their ability to escape host defense and establish chronic infections. Molecular crosstalk between the host and the parasite starts immediately after their encounter, which influences the course and development of both the innate and adaptive arms of the immune response. Helminths can modulate dendritic cells (DCs) function and induce immunosuppression which is mediated by a regulatory network that includes regulatory T (Treg) cells, regulatory B (Breg) cells, and alternatively activated macrophages (AAMs). In this way, helminths suppress and control both parasite-specific and unrelated immunopathology in the host such as Th1-mediated autoimmune and Th2-mediated allergic diseases. However, certain helminths favour the development or exacerbation of allergic responses. In this paper, the cell types that play an essential role in helminth-induced immunoregulation, the consequences for inflammatory diseases, and the contrasting effects of Toxocara and Trichinella infection on allergic manifestations are discussed.http://dx.doi.org/10.1155/2013/329438 |
| spellingShingle | Carmen Aranzamendi Ljiljana Sofronic-Milosavljevic Elena Pinelli Helminths: Immunoregulation and Inflammatory Diseases—Which Side Are Trichinella spp. and Toxocara spp. on? Journal of Parasitology Research |
| title | Helminths: Immunoregulation and Inflammatory Diseases—Which Side Are Trichinella spp. and Toxocara spp. on? |
| title_full | Helminths: Immunoregulation and Inflammatory Diseases—Which Side Are Trichinella spp. and Toxocara spp. on? |
| title_fullStr | Helminths: Immunoregulation and Inflammatory Diseases—Which Side Are Trichinella spp. and Toxocara spp. on? |
| title_full_unstemmed | Helminths: Immunoregulation and Inflammatory Diseases—Which Side Are Trichinella spp. and Toxocara spp. on? |
| title_short | Helminths: Immunoregulation and Inflammatory Diseases—Which Side Are Trichinella spp. and Toxocara spp. on? |
| title_sort | helminths immunoregulation and inflammatory diseases which side are trichinella spp and toxocara spp on |
| url | http://dx.doi.org/10.1155/2013/329438 |
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