Cytokines interferon-γ- inducible protein 10 and granulocyte-macrophage colony-stimulating factor are associated with psychiatric symptoms in opioid-dependent patients: A cross- sectional study.
<h4>Background</h4>Psychiatric disorders and chronic hepatitis virus C infection are known to alter blood cytokines levels. However, little is known about the association between cytokines and psychiatric symptoms in patients with chronic hepatitis C virus infection. This study aimed at...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0324365 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849228191067013120 |
|---|---|
| author | Kristin Nygård Odeh Hedda Soløy Nilsen Magnhild Gangsøy Kristiansen Ole Lars Brekke Tom Eirik Mollnes Michael Berk |
| author_facet | Kristin Nygård Odeh Hedda Soløy Nilsen Magnhild Gangsøy Kristiansen Ole Lars Brekke Tom Eirik Mollnes Michael Berk |
| author_sort | Kristin Nygård Odeh |
| collection | DOAJ |
| description | <h4>Background</h4>Psychiatric disorders and chronic hepatitis virus C infection are known to alter blood cytokines levels. However, little is known about the association between cytokines and psychiatric symptoms in patients with chronic hepatitis C virus infection. This study aimed at exploring this association. Moreover, since nearly half of the patients receive opioid maintenance treatment, we also investigated if long-term opioid treatment had any impact on these associations.<h4>Methods</h4>We conducted a cross-sectional study on 120 outpatients referred for antiviral hepatitis C treatment. Serum level of 27 cytokines was measured using multiplex technology, and psychiatric symptom clusters were assessed using the Symptoms Check-List-90-R. Data on confounding factors including age, gender, weight, height, current medication and smoking habits were collected. Multiple linear regression analysis was performed to examine associations, adjusting for confounding factors.<h4>Results</h4>After adjusting for the most commonly known confounding factors, IP-10 and GM-CSF were negatively associated with depression, and GM-CSF was negatively associated with phobic anxiety. Subgroup analyses revealed that these associations were present only in patients receiving opioid maintenance treatment, as demonstrated by repeated regression analysis.<h4>Conclusions</h4>In patients with chronic hepatitis C viral infection, only IP-10 and GM-CSF were negatively associated with self-reported psychiatric symptom clusters. These associations were observed exclusively in patients receiving opioid maintenance treatment. Our study contributes to others investigations pointing to a possible immune dampening caused by long-term opioid treatment. |
| format | Article |
| id | doaj-art-e62e63eb280648c8b7b348d0fb55df6f |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e62e63eb280648c8b7b348d0fb55df6f2025-08-23T05:31:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01208e032436510.1371/journal.pone.0324365Cytokines interferon-γ- inducible protein 10 and granulocyte-macrophage colony-stimulating factor are associated with psychiatric symptoms in opioid-dependent patients: A cross- sectional study.Kristin Nygård OdehHedda Soløy NilsenMagnhild Gangsøy KristiansenOle Lars BrekkeTom Eirik MollnesMichael Berk<h4>Background</h4>Psychiatric disorders and chronic hepatitis virus C infection are known to alter blood cytokines levels. However, little is known about the association between cytokines and psychiatric symptoms in patients with chronic hepatitis C virus infection. This study aimed at exploring this association. Moreover, since nearly half of the patients receive opioid maintenance treatment, we also investigated if long-term opioid treatment had any impact on these associations.<h4>Methods</h4>We conducted a cross-sectional study on 120 outpatients referred for antiviral hepatitis C treatment. Serum level of 27 cytokines was measured using multiplex technology, and psychiatric symptom clusters were assessed using the Symptoms Check-List-90-R. Data on confounding factors including age, gender, weight, height, current medication and smoking habits were collected. Multiple linear regression analysis was performed to examine associations, adjusting for confounding factors.<h4>Results</h4>After adjusting for the most commonly known confounding factors, IP-10 and GM-CSF were negatively associated with depression, and GM-CSF was negatively associated with phobic anxiety. Subgroup analyses revealed that these associations were present only in patients receiving opioid maintenance treatment, as demonstrated by repeated regression analysis.<h4>Conclusions</h4>In patients with chronic hepatitis C viral infection, only IP-10 and GM-CSF were negatively associated with self-reported psychiatric symptom clusters. These associations were observed exclusively in patients receiving opioid maintenance treatment. Our study contributes to others investigations pointing to a possible immune dampening caused by long-term opioid treatment.https://doi.org/10.1371/journal.pone.0324365 |
| spellingShingle | Kristin Nygård Odeh Hedda Soløy Nilsen Magnhild Gangsøy Kristiansen Ole Lars Brekke Tom Eirik Mollnes Michael Berk Cytokines interferon-γ- inducible protein 10 and granulocyte-macrophage colony-stimulating factor are associated with psychiatric symptoms in opioid-dependent patients: A cross- sectional study. PLoS ONE |
| title | Cytokines interferon-γ- inducible protein 10 and granulocyte-macrophage colony-stimulating factor are associated with psychiatric symptoms in opioid-dependent patients: A cross- sectional study. |
| title_full | Cytokines interferon-γ- inducible protein 10 and granulocyte-macrophage colony-stimulating factor are associated with psychiatric symptoms in opioid-dependent patients: A cross- sectional study. |
| title_fullStr | Cytokines interferon-γ- inducible protein 10 and granulocyte-macrophage colony-stimulating factor are associated with psychiatric symptoms in opioid-dependent patients: A cross- sectional study. |
| title_full_unstemmed | Cytokines interferon-γ- inducible protein 10 and granulocyte-macrophage colony-stimulating factor are associated with psychiatric symptoms in opioid-dependent patients: A cross- sectional study. |
| title_short | Cytokines interferon-γ- inducible protein 10 and granulocyte-macrophage colony-stimulating factor are associated with psychiatric symptoms in opioid-dependent patients: A cross- sectional study. |
| title_sort | cytokines interferon γ inducible protein 10 and granulocyte macrophage colony stimulating factor are associated with psychiatric symptoms in opioid dependent patients a cross sectional study |
| url | https://doi.org/10.1371/journal.pone.0324365 |
| work_keys_str_mv | AT kristinnygardodeh cytokinesinterferonginducibleprotein10andgranulocytemacrophagecolonystimulatingfactorareassociatedwithpsychiatricsymptomsinopioiddependentpatientsacrosssectionalstudy AT heddasoløynilsen cytokinesinterferonginducibleprotein10andgranulocytemacrophagecolonystimulatingfactorareassociatedwithpsychiatricsymptomsinopioiddependentpatientsacrosssectionalstudy AT magnhildgangsøykristiansen cytokinesinterferonginducibleprotein10andgranulocytemacrophagecolonystimulatingfactorareassociatedwithpsychiatricsymptomsinopioiddependentpatientsacrosssectionalstudy AT olelarsbrekke cytokinesinterferonginducibleprotein10andgranulocytemacrophagecolonystimulatingfactorareassociatedwithpsychiatricsymptomsinopioiddependentpatientsacrosssectionalstudy AT tomeirikmollnes cytokinesinterferonginducibleprotein10andgranulocytemacrophagecolonystimulatingfactorareassociatedwithpsychiatricsymptomsinopioiddependentpatientsacrosssectionalstudy AT michaelberk cytokinesinterferonginducibleprotein10andgranulocytemacrophagecolonystimulatingfactorareassociatedwithpsychiatricsymptomsinopioiddependentpatientsacrosssectionalstudy |