Progress of p53/p21 pathway and cell cycle arres in acute kidney injury research
As one of the most common acute and severe diseases in hospitalized patients, acute kidney injury(AKI) can sharply decrease kidney function. DNA damage exists in the early stages of AKI, and one of the major cellular responses to DNA damage is cell cycle arrest, in which the tumor protein p53 plays...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Clinical Nephrology
2019-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57910804&Fpath=home&index=0 |
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| author | LIU Zhuo-liang LI Ya-feng LI Rong-shan |
| author_facet | LIU Zhuo-liang LI Ya-feng LI Rong-shan |
| author_sort | LIU Zhuo-liang |
| collection | DOAJ |
| description | As one of the most common acute and severe diseases in hospitalized patients, acute kidney injury(AKI) can sharply decrease kidney function. DNA damage exists in the early stages of AKI, and one of the major cellular responses to DNA damage is cell cycle arrest, in which the tumor protein p53 plays an important role. Based on our knowledge of the p53/p21 signaling pathway and DNA damage to date, this review focuses on the role of cell cycle arrest and the p53/p21 signaling pathway in progression of AKI. A better understanding of protective effect of cell cycle arrest, and the mechanisms and function of the p53/p21 signaling pathway will enable the development of therapeutic strategies for treating AKI. |
| format | Article |
| id | doaj-art-e62c2f033cdd4f4290f6ce7dc7800e1b |
| institution | DOAJ |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2019-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-e62c2f033cdd4f4290f6ce7dc7800e1b2025-08-20T03:09:27ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902019-01-011953453957910804Progress of p53/p21 pathway and cell cycle arres in acute kidney injury researchLIU Zhuo-liangLI Ya-fengLI Rong-shanAs one of the most common acute and severe diseases in hospitalized patients, acute kidney injury(AKI) can sharply decrease kidney function. DNA damage exists in the early stages of AKI, and one of the major cellular responses to DNA damage is cell cycle arrest, in which the tumor protein p53 plays an important role. Based on our knowledge of the p53/p21 signaling pathway and DNA damage to date, this review focuses on the role of cell cycle arrest and the p53/p21 signaling pathway in progression of AKI. A better understanding of protective effect of cell cycle arrest, and the mechanisms and function of the p53/p21 signaling pathway will enable the development of therapeutic strategies for treating AKI.http://www.lcszb.com/thesisDetails?columnId=57910804&Fpath=home&index=0DNA damagep53/p21 pathwayCell cycle arrestAcute kidney injury |
| spellingShingle | LIU Zhuo-liang LI Ya-feng LI Rong-shan Progress of p53/p21 pathway and cell cycle arres in acute kidney injury research Linchuang shenzangbing zazhi DNA damage p53/p21 pathway Cell cycle arrest Acute kidney injury |
| title | Progress of p53/p21 pathway and cell cycle arres in acute kidney injury research |
| title_full | Progress of p53/p21 pathway and cell cycle arres in acute kidney injury research |
| title_fullStr | Progress of p53/p21 pathway and cell cycle arres in acute kidney injury research |
| title_full_unstemmed | Progress of p53/p21 pathway and cell cycle arres in acute kidney injury research |
| title_short | Progress of p53/p21 pathway and cell cycle arres in acute kidney injury research |
| title_sort | progress of p53 p21 pathway and cell cycle arres in acute kidney injury research |
| topic | DNA damage p53/p21 pathway Cell cycle arrest Acute kidney injury |
| url | http://www.lcszb.com/thesisDetails?columnId=57910804&Fpath=home&index=0 |
| work_keys_str_mv | AT liuzhuoliang progressofp53p21pathwayandcellcyclearresinacutekidneyinjuryresearch AT liyafeng progressofp53p21pathwayandcellcyclearresinacutekidneyinjuryresearch AT lirongshan progressofp53p21pathwayandcellcyclearresinacutekidneyinjuryresearch |