Neonatal Chylothoraces: A 10-Year Experience in a Tertiary Neonatal Referral Centre
Background. Neonatal chylothorax is a rare condition, but has a high mortality. Study Objectives. To analyse the outcomes of a series of neonates with chylothorax and review the literature to determine best practice. Design. A case series review and a literature review using electronic databases inc...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2019/3903598 |
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| _version_ | 1850168170691690496 |
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| author | Marie K. White Ravindra Bhat Anne Greenough |
| author_facet | Marie K. White Ravindra Bhat Anne Greenough |
| author_sort | Marie K. White |
| collection | DOAJ |
| description | Background. Neonatal chylothorax is a rare condition, but has a high mortality. Study Objectives. To analyse the outcomes of a series of neonates with chylothorax and review the literature to determine best practice. Design. A case series review and a literature review using electronic databases including the key words neonates and chylothorax. Results. Six cases of neonatal chylothorax were identified during a ten-year period, two had congenital chylothoraces and four iatrogenic chylothoraces after thoracic surgery or chest instrumentation. The neonates were ventilated for a median of 30 (range 13–125) days with a median maximum daily pleural fluid output of 218 (range 86–310) ml/kg/day. All the neonates were given medium-chain triglyceride (MCT) feeds which stabilised pleural fluid output in four and reduced it in another. Octreotide was used in three neonates, but the dosage used had no significant effect on pleural output. Two neonates required surgical intervention. The literature review demonstrated MCT feeds can reduce or stabilise pleural fluid output, but highlighted variable use of octreotide and inconsistent dosing regimens and outcomes. No consensus regarding indications for surgical intervention was identified. Summary and Conclusion. Neonatal chylothorax is uncommon, but affected neonates require high healthcare utilisation. |
| format | Article |
| id | doaj-art-e6299168af15430581caad113875f79a |
| institution | OA Journals |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-e6299168af15430581caad113875f79a2025-08-20T02:21:02ZengWileyCase Reports in Pediatrics2090-68032090-68112019-01-01201910.1155/2019/39035983903598Neonatal Chylothoraces: A 10-Year Experience in a Tertiary Neonatal Referral CentreMarie K. White0Ravindra Bhat1Anne Greenough2Neonatal Intensive Care Centre, Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UKNeonatal Intensive Care Centre, Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UKNeonatal Intensive Care Centre, Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UKBackground. Neonatal chylothorax is a rare condition, but has a high mortality. Study Objectives. To analyse the outcomes of a series of neonates with chylothorax and review the literature to determine best practice. Design. A case series review and a literature review using electronic databases including the key words neonates and chylothorax. Results. Six cases of neonatal chylothorax were identified during a ten-year period, two had congenital chylothoraces and four iatrogenic chylothoraces after thoracic surgery or chest instrumentation. The neonates were ventilated for a median of 30 (range 13–125) days with a median maximum daily pleural fluid output of 218 (range 86–310) ml/kg/day. All the neonates were given medium-chain triglyceride (MCT) feeds which stabilised pleural fluid output in four and reduced it in another. Octreotide was used in three neonates, but the dosage used had no significant effect on pleural output. Two neonates required surgical intervention. The literature review demonstrated MCT feeds can reduce or stabilise pleural fluid output, but highlighted variable use of octreotide and inconsistent dosing regimens and outcomes. No consensus regarding indications for surgical intervention was identified. Summary and Conclusion. Neonatal chylothorax is uncommon, but affected neonates require high healthcare utilisation.http://dx.doi.org/10.1155/2019/3903598 |
| spellingShingle | Marie K. White Ravindra Bhat Anne Greenough Neonatal Chylothoraces: A 10-Year Experience in a Tertiary Neonatal Referral Centre Case Reports in Pediatrics |
| title | Neonatal Chylothoraces: A 10-Year Experience in a Tertiary Neonatal Referral Centre |
| title_full | Neonatal Chylothoraces: A 10-Year Experience in a Tertiary Neonatal Referral Centre |
| title_fullStr | Neonatal Chylothoraces: A 10-Year Experience in a Tertiary Neonatal Referral Centre |
| title_full_unstemmed | Neonatal Chylothoraces: A 10-Year Experience in a Tertiary Neonatal Referral Centre |
| title_short | Neonatal Chylothoraces: A 10-Year Experience in a Tertiary Neonatal Referral Centre |
| title_sort | neonatal chylothoraces a 10 year experience in a tertiary neonatal referral centre |
| url | http://dx.doi.org/10.1155/2019/3903598 |
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