Association Between Long-Term Exposure to Ambient Air Pollution and Fasting Blood Glucose: A Systematic Review and Meta-Analysis
Increasing studies are indicating a potential association between ambient air pollution exposure and fasting blood glucose (FBG), an indicator of prediabetes and diabetes. However, there is inconsistency within the existing literature. The aim of this study was to summarize the associations of expos...
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MDPI AG
2024-10-01
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| author | Tong Wu Yang Lan Ge Li Kai Wang Yu You Jiaqi Zhu Lihua Ren Shaowei Wu |
| author_facet | Tong Wu Yang Lan Ge Li Kai Wang Yu You Jiaqi Zhu Lihua Ren Shaowei Wu |
| author_sort | Tong Wu |
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| description | Increasing studies are indicating a potential association between ambient air pollution exposure and fasting blood glucose (FBG), an indicator of prediabetes and diabetes. However, there is inconsistency within the existing literature. The aim of this study was to summarize the associations of exposures to particulate matters (PMs) (with aerodynamic diameters of ≤1 μm (PM<sub>1</sub>), ≤2.5 μm (PM<sub>2.5</sub>), and ≤10 μm (PM<sub>10</sub>), respectively) and gaseous pollutants (sulfur dioxide (SO<sub>2</sub>), nitrogen dioxide (NO<sub>2</sub>) and ozone (O<sub>3</sub>)) with FBG based on the existing epidemiological research for a better understanding of the relationship between air pollution and diabetes. Up to 2 July 2024, we performed a comprehensive literature retrieval from various electronic databases (PubMed, Web of Science, Scopus, and Embase). Random-effect and fixed-effect models were utilized to estimate the pooled percent changes (%) and 95% confidence intervals (CIs). Then, subgroup meta-analyses and meta-regression analyses were applied to recognize the sources of heterogeneity. There were 33 studies eligible for the meta-analysis. The results showed that for each 10 μg/m<sup>3</sup> increase in long-term exposures to PM<sub>1</sub>, PM<sub>2.5</sub>, PM<sub>10</sub>, and SO<sub>2</sub>, the pooled percent changes in FBG were 2.24% (95% CI: 0.54%, 3.96%), 1.72% (95% CI: 0.93%, 2.25%), 1.19% (95% CI: 0.41%, 1.97%), and 0.52% (95% CI:0.40%, 0.63%), respectively. Long-term exposures to ambient NO<sub>2</sub> and O<sub>3</sub> were not related to alterations in FBG. In conclusion, our findings support that long-term exposures to PMs of various aerodynamic diameters and SO<sub>2</sub> are associated with significantly elevated FBG levels. |
| format | Article |
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| institution | OA Journals |
| issn | 2305-6304 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Toxics |
| spelling | doaj-art-e629702ef0aa4b9b86698afd83c4d79c2025-08-20T02:04:44ZengMDPI AGToxics2305-63042024-10-01121179210.3390/toxics12110792Association Between Long-Term Exposure to Ambient Air Pollution and Fasting Blood Glucose: A Systematic Review and Meta-AnalysisTong Wu0Yang Lan1Ge Li2Kai Wang3Yu You4Jiaqi Zhu5Lihua Ren6Shaowei Wu7Department of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, ChinaSchool of Nursing, Peking University, Beijing 100871, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, ChinaIncreasing studies are indicating a potential association between ambient air pollution exposure and fasting blood glucose (FBG), an indicator of prediabetes and diabetes. However, there is inconsistency within the existing literature. The aim of this study was to summarize the associations of exposures to particulate matters (PMs) (with aerodynamic diameters of ≤1 μm (PM<sub>1</sub>), ≤2.5 μm (PM<sub>2.5</sub>), and ≤10 μm (PM<sub>10</sub>), respectively) and gaseous pollutants (sulfur dioxide (SO<sub>2</sub>), nitrogen dioxide (NO<sub>2</sub>) and ozone (O<sub>3</sub>)) with FBG based on the existing epidemiological research for a better understanding of the relationship between air pollution and diabetes. Up to 2 July 2024, we performed a comprehensive literature retrieval from various electronic databases (PubMed, Web of Science, Scopus, and Embase). Random-effect and fixed-effect models were utilized to estimate the pooled percent changes (%) and 95% confidence intervals (CIs). Then, subgroup meta-analyses and meta-regression analyses were applied to recognize the sources of heterogeneity. There were 33 studies eligible for the meta-analysis. The results showed that for each 10 μg/m<sup>3</sup> increase in long-term exposures to PM<sub>1</sub>, PM<sub>2.5</sub>, PM<sub>10</sub>, and SO<sub>2</sub>, the pooled percent changes in FBG were 2.24% (95% CI: 0.54%, 3.96%), 1.72% (95% CI: 0.93%, 2.25%), 1.19% (95% CI: 0.41%, 1.97%), and 0.52% (95% CI:0.40%, 0.63%), respectively. Long-term exposures to ambient NO<sub>2</sub> and O<sub>3</sub> were not related to alterations in FBG. In conclusion, our findings support that long-term exposures to PMs of various aerodynamic diameters and SO<sub>2</sub> are associated with significantly elevated FBG levels.https://www.mdpi.com/2305-6304/12/11/792air pollutionfasting blood glucosegaseous pollutantmeta-analysisparticulate matter |
| spellingShingle | Tong Wu Yang Lan Ge Li Kai Wang Yu You Jiaqi Zhu Lihua Ren Shaowei Wu Association Between Long-Term Exposure to Ambient Air Pollution and Fasting Blood Glucose: A Systematic Review and Meta-Analysis Toxics air pollution fasting blood glucose gaseous pollutant meta-analysis particulate matter |
| title | Association Between Long-Term Exposure to Ambient Air Pollution and Fasting Blood Glucose: A Systematic Review and Meta-Analysis |
| title_full | Association Between Long-Term Exposure to Ambient Air Pollution and Fasting Blood Glucose: A Systematic Review and Meta-Analysis |
| title_fullStr | Association Between Long-Term Exposure to Ambient Air Pollution and Fasting Blood Glucose: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association Between Long-Term Exposure to Ambient Air Pollution and Fasting Blood Glucose: A Systematic Review and Meta-Analysis |
| title_short | Association Between Long-Term Exposure to Ambient Air Pollution and Fasting Blood Glucose: A Systematic Review and Meta-Analysis |
| title_sort | association between long term exposure to ambient air pollution and fasting blood glucose a systematic review and meta analysis |
| topic | air pollution fasting blood glucose gaseous pollutant meta-analysis particulate matter |
| url | https://www.mdpi.com/2305-6304/12/11/792 |
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