Association between serum glucose potassium ratio and mortality in critically ill patients with intracerebral hemorrhage
Abstract The effect of serum glucose-to-potassium ratio (GPR) on cerebrovascular diseases has been previously validated. However, the value of the GPR in patients with severe intracerebral hemorrhage (ICH) requiring ICU admission remains unclear. This study aimed to investigate the association betwe...
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Nature Portfolio
2024-11-01
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| Online Access: | https://doi.org/10.1038/s41598-024-78230-8 |
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| author | Jianyi Liu Fuqun Luo Yizhi Guo Yandeng Li Chao Jiang Zhendong Pi Jie Luo Zhiyuan Long Jun Wen Zhihua Huang Jianming Zhu |
| author_facet | Jianyi Liu Fuqun Luo Yizhi Guo Yandeng Li Chao Jiang Zhendong Pi Jie Luo Zhiyuan Long Jun Wen Zhihua Huang Jianming Zhu |
| author_sort | Jianyi Liu |
| collection | DOAJ |
| description | Abstract The effect of serum glucose-to-potassium ratio (GPR) on cerebrovascular diseases has been previously validated. However, the value of the GPR in patients with severe intracerebral hemorrhage (ICH) requiring ICU admission remains unclear. This study aimed to investigate the association between the GPR and the clinical prognosis of critically ill patients with ICH. This study identified patients with severe ICH requiring ICU admission from the Medical Information Mart for Intensive Care (MIMIC-IV) database and divided them into quartiles based on GPR levels. Outcomes included 30-day, 90-day, and 1-year mortality rates. The association between the GPR and clinical outcomes in critically ill patients with ICH was elucidated using Cox proportional hazards regression analysis and restricted cubic splines. In total, 2018 patients (53.8% male), with a median age of 70 years, were enrolled in the study. The 30-day, 90-day, and 1-year mortality rates were 23.9%, 30.1%, and 38.4%, respectively. Per multivariate Cox proportional hazards analysis, an elevated GPR was significantly associated with all-cause mortality. After adjusting for age, sex, Charlson Comorbidity Index, white blood cell count, red blood cell count, platelet count, and Glasgow Coma Scale, patients with an elevated GPR had a higher 30-day mortality (hazard ratio [HR]: 1.32; 95% confidence interval [CI]: 1.22–1.42; P < 0.001), 90-day mortality (HR: 1.27; 95% CI: 1.18–1.37; P < 0.001) and 1-year mortality (HR: 1.22; 95% CI: 1.14–1.31; P < 0.001) when analyzed as a continuous variable. Furthermore, analysis using restricted cubic splines demonstrated a consistent and progressive escalation in the risk of all-cause mortality with an elevated GPR. The GPR was significantly associated with short- and long-term all-cause mortality in critically ill patients with ICH. This finding demonstrates that GPR may be useful in identifying patients with ICH at a high risk of all-cause mortality. |
| format | Article |
| id | doaj-art-e6281117886c4650bf2ec79791ae1c58 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-e6281117886c4650bf2ec79791ae1c582025-08-20T02:13:27ZengNature PortfolioScientific Reports2045-23222024-11-0114111010.1038/s41598-024-78230-8Association between serum glucose potassium ratio and mortality in critically ill patients with intracerebral hemorrhageJianyi Liu0Fuqun Luo1Yizhi Guo2Yandeng Li3Chao Jiang4Zhendong Pi5Jie Luo6Zhiyuan Long7Jun Wen8Zhihua Huang9Jianming Zhu10Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City)Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City)Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City)Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City)Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City)Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City)Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City)Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City)Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City)Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City)Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City)Abstract The effect of serum glucose-to-potassium ratio (GPR) on cerebrovascular diseases has been previously validated. However, the value of the GPR in patients with severe intracerebral hemorrhage (ICH) requiring ICU admission remains unclear. This study aimed to investigate the association between the GPR and the clinical prognosis of critically ill patients with ICH. This study identified patients with severe ICH requiring ICU admission from the Medical Information Mart for Intensive Care (MIMIC-IV) database and divided them into quartiles based on GPR levels. Outcomes included 30-day, 90-day, and 1-year mortality rates. The association between the GPR and clinical outcomes in critically ill patients with ICH was elucidated using Cox proportional hazards regression analysis and restricted cubic splines. In total, 2018 patients (53.8% male), with a median age of 70 years, were enrolled in the study. The 30-day, 90-day, and 1-year mortality rates were 23.9%, 30.1%, and 38.4%, respectively. Per multivariate Cox proportional hazards analysis, an elevated GPR was significantly associated with all-cause mortality. After adjusting for age, sex, Charlson Comorbidity Index, white blood cell count, red blood cell count, platelet count, and Glasgow Coma Scale, patients with an elevated GPR had a higher 30-day mortality (hazard ratio [HR]: 1.32; 95% confidence interval [CI]: 1.22–1.42; P < 0.001), 90-day mortality (HR: 1.27; 95% CI: 1.18–1.37; P < 0.001) and 1-year mortality (HR: 1.22; 95% CI: 1.14–1.31; P < 0.001) when analyzed as a continuous variable. Furthermore, analysis using restricted cubic splines demonstrated a consistent and progressive escalation in the risk of all-cause mortality with an elevated GPR. The GPR was significantly associated with short- and long-term all-cause mortality in critically ill patients with ICH. This finding demonstrates that GPR may be useful in identifying patients with ICH at a high risk of all-cause mortality.https://doi.org/10.1038/s41598-024-78230-8Intracerebral hemorrhageGlucose-to-potassium ratioMortality |
| spellingShingle | Jianyi Liu Fuqun Luo Yizhi Guo Yandeng Li Chao Jiang Zhendong Pi Jie Luo Zhiyuan Long Jun Wen Zhihua Huang Jianming Zhu Association between serum glucose potassium ratio and mortality in critically ill patients with intracerebral hemorrhage Scientific Reports Intracerebral hemorrhage Glucose-to-potassium ratio Mortality |
| title | Association between serum glucose potassium ratio and mortality in critically ill patients with intracerebral hemorrhage |
| title_full | Association between serum glucose potassium ratio and mortality in critically ill patients with intracerebral hemorrhage |
| title_fullStr | Association between serum glucose potassium ratio and mortality in critically ill patients with intracerebral hemorrhage |
| title_full_unstemmed | Association between serum glucose potassium ratio and mortality in critically ill patients with intracerebral hemorrhage |
| title_short | Association between serum glucose potassium ratio and mortality in critically ill patients with intracerebral hemorrhage |
| title_sort | association between serum glucose potassium ratio and mortality in critically ill patients with intracerebral hemorrhage |
| topic | Intracerebral hemorrhage Glucose-to-potassium ratio Mortality |
| url | https://doi.org/10.1038/s41598-024-78230-8 |
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