Primary Cardiac Angiosarcoma: A Fatal Disease

A 42-year-old man with a cardiac tamponade underwent an urgent pericardiotomy that showed tumoral tissue, covering the surface of the right atrium. The tumor was then partially excised, and the histological examination revealed the presence of a moderately-differentiated angiosarcoma. The patient wa...

Full description

Saved in:
Bibliographic Details
Main Authors: L. Antonuzzo, V. Rotella, F. Mazzoni, L. Doni, D. Bianchini, F. Garbini, V. Maio, F. Di Costanzo
Format: Article
Language:English
Published: Wiley 2009-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2009/591512
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832558069983215616
author L. Antonuzzo
V. Rotella
F. Mazzoni
L. Doni
D. Bianchini
F. Garbini
V. Maio
F. Di Costanzo
author_facet L. Antonuzzo
V. Rotella
F. Mazzoni
L. Doni
D. Bianchini
F. Garbini
V. Maio
F. Di Costanzo
author_sort L. Antonuzzo
collection DOAJ
description A 42-year-old man with a cardiac tamponade underwent an urgent pericardiotomy that showed tumoral tissue, covering the surface of the right atrium. The tumor was then partially excised, and the histological examination revealed the presence of a moderately-differentiated angiosarcoma. The patient was then referred to the oncology unit and scheduled for a chemotherapy schedule including Epirubicin (60 mg/m2, on days 1 and 2) plus Ifosfamide (2000 mg/m2, on days 1 to 3) and Uromitexan (2000 mg/m2 at hours 0, 4, 8 after IFO). All drugs were administered every three weeks. After two cycles, a restaging work-up revealed a partial remission. The treatment was continued for another two cycles. A new evaluation by cardiac MRI evidenced a local and distant (lung) progression of disease. The patient died after three months. This paper confirms that cardiac angiosarcoma is a fatal disease, and the prognosis is usually 6–11 months from time of diagnosis.
format Article
id doaj-art-e6245ee923834d518655d1138c25453b
institution Kabale University
issn 1687-9627
1687-9635
language English
publishDate 2009-01-01
publisher Wiley
record_format Article
series Case Reports in Medicine
spelling doaj-art-e6245ee923834d518655d1138c25453b2025-02-03T01:33:29ZengWileyCase Reports in Medicine1687-96271687-96352009-01-01200910.1155/2009/591512591512Primary Cardiac Angiosarcoma: A Fatal DiseaseL. Antonuzzo0V. Rotella1F. Mazzoni2L. Doni3D. Bianchini4F. Garbini5V. Maio6F. Di Costanzo7Oncologia Medica, Azienda Ospedale Universitaria Careggi, Viale Pieraccini 17, 50139 Firenze, ItalyOncologia Medica, Azienda Ospedale Universitaria Careggi, Viale Pieraccini 17, 50139 Firenze, ItalyOncologia Medica, Azienda Ospedale Universitaria Careggi, Viale Pieraccini 17, 50139 Firenze, ItalyOncologia Medica, Azienda Ospedale Universitaria Careggi, Viale Pieraccini 17, 50139 Firenze, ItalyOncologia Medica, Azienda Ospedale Universitaria Careggi, Viale Pieraccini 17, 50139 Firenze, ItalyDipartimento di Patologia Umana ed Oncologia, Azienda Ospedale Universitaria Careggi, Viale Pieraccini 17, 50139 Firenze, ItalyDipartimento di Patologia Umana ed Oncologia, Azienda Ospedale Universitaria Careggi, Viale Pieraccini 17, 50139 Firenze, ItalyOncologia Medica, Azienda Ospedale Universitaria Careggi, Viale Pieraccini 17, 50139 Firenze, ItalyA 42-year-old man with a cardiac tamponade underwent an urgent pericardiotomy that showed tumoral tissue, covering the surface of the right atrium. The tumor was then partially excised, and the histological examination revealed the presence of a moderately-differentiated angiosarcoma. The patient was then referred to the oncology unit and scheduled for a chemotherapy schedule including Epirubicin (60 mg/m2, on days 1 and 2) plus Ifosfamide (2000 mg/m2, on days 1 to 3) and Uromitexan (2000 mg/m2 at hours 0, 4, 8 after IFO). All drugs were administered every three weeks. After two cycles, a restaging work-up revealed a partial remission. The treatment was continued for another two cycles. A new evaluation by cardiac MRI evidenced a local and distant (lung) progression of disease. The patient died after three months. This paper confirms that cardiac angiosarcoma is a fatal disease, and the prognosis is usually 6–11 months from time of diagnosis.http://dx.doi.org/10.1155/2009/591512
spellingShingle L. Antonuzzo
V. Rotella
F. Mazzoni
L. Doni
D. Bianchini
F. Garbini
V. Maio
F. Di Costanzo
Primary Cardiac Angiosarcoma: A Fatal Disease
Case Reports in Medicine
title Primary Cardiac Angiosarcoma: A Fatal Disease
title_full Primary Cardiac Angiosarcoma: A Fatal Disease
title_fullStr Primary Cardiac Angiosarcoma: A Fatal Disease
title_full_unstemmed Primary Cardiac Angiosarcoma: A Fatal Disease
title_short Primary Cardiac Angiosarcoma: A Fatal Disease
title_sort primary cardiac angiosarcoma a fatal disease
url http://dx.doi.org/10.1155/2009/591512
work_keys_str_mv AT lantonuzzo primarycardiacangiosarcomaafataldisease
AT vrotella primarycardiacangiosarcomaafataldisease
AT fmazzoni primarycardiacangiosarcomaafataldisease
AT ldoni primarycardiacangiosarcomaafataldisease
AT dbianchini primarycardiacangiosarcomaafataldisease
AT fgarbini primarycardiacangiosarcomaafataldisease
AT vmaio primarycardiacangiosarcomaafataldisease
AT fdicostanzo primarycardiacangiosarcomaafataldisease