<sup>225</sup>Aс-PSMA-617 therapy in metastatic castration-resistant prostate cancer

<sup>225</sup>Aс-PSMA-617 therapy in metastatic castration-resistant prostate cancer

177Lu-PSMA-617 is a new therapy option for PSMA-positive metastatic castrate-resistant metastatic prostate cancer (mCRPC) with proven efficacy. 225Ac-PCMA-617 is an alpha emitter, making this drug potentially more powerful. Despite the active use of 225Ac-PSMA-617 worldwide, no randomized phase III...

Full description

Saved in:

Bibliographic Details
Main Authors:	T. Yu. Kochetova, V. V. Krylov, S. A. Ivanov, A. D. Kaprin
Format:	Article
Language:	Russian
Published:	Russian Academy of Sciences, Tomsk National Research Medical Center 2025-01-01
Series:	Сибирский онкологический журнал
Subjects:	radioligand therapy <sup>225</sup>ac-psma-617 castrate-resistant prostate cancer radium chloride [<sup>223</sup>ra] overall survival
Online Access:	https://www.siboncoj.ru/jour/article/view/3360
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Efficacy of <sup>177</sup>Lu-PSMA-617 Therapy in mCRPC Patients with Liver Metastases: Insights into Survival Outcomes and Predictors of Response
by: Ebuzer Kalender, et al.
Published: (2025-02-01)

Actinium-225-PSMA-617 treatment in a patient with advanced prostate cancer causes secondary myelofibrosis: a case report and literature review
by: Ziye Wang, et al.
Published: (2025-07-01)

Improvement of End-of-Synthesis Radiochemical Purity of <sup>177</sup>Lu-DOTA-PSMA-Ligands with Alternative Synthesis Approaches: Conversion Upswing and Side-Products Minimization
by: Anton Larenkov, et al.
Published: (2024-11-01)

Comparison of ZnS(Ag) Scintillator and Proportional Counter Tube for Alpha Detection in Thin-Layer Chromatography
by: Marc Pretze, et al.
Published: (2024-12-01)

Theranostics Nuclear Medicine in Prostate Cancer
by: Helena Lima, et al.
Published: (2024-11-01)

Long-Term Therapeutic Effects of <sup>225</sup>Ac-DOTA-E[c(RGDfK)]<sub>2</sub> Induced by Radiosensitization via G2/M Arrest in Pancreatic Ductal Adenocarcinoma
by: Mitsuyoshi Yoshimoto, et al.
Published: (2024-12-01)

Estimation of absorbed doses in patients’ organs from the released radionuclide-label during radionuclide therapy with <sup>225</sup>Ac
by: A. E. Petrova, et al.
Published: (2022-04-01)

USE OF <sup>177</sup>Lu-PSMA FOR RADIONUCLIDE THERAPY IN PATIENTS WITH CASTRATE-RESISTANT PROSTATE CANCER
by: A. A. Medvedeva, et al.
Published: (2021-06-01)

Different <sup>212</sup>Pb Generators and Its Radiation Safety Concerning <sup>220</sup>Rn (Thoron) Emanation
by: Marc Pretze, et al.
Published: (2025-05-01)

Optimization Processes of Clinical Chelation-Based Radiopharmaceuticals for Pathway-Directed Targeted Radionuclide Therapy in Oncology
by: Katsumi Tomiyoshi, et al.
Published: (2024-11-01)

Furosemide Reduces Radionuclide Activity in the Bladder in <sup>18</sup>F-PSMA-1007-PET/CT: A Single-Center Retrospective Intra-Individual Comparative Study
by: Martin A. Cahenzli, et al.
Published: (2025-07-01)

The content of natural radionuclides Ra<sup>226</sup>, Th<sup>232</sup>, K<sup>40</sup> in titanium ores and host rocks of the Pizhemskoye deposit
by: A. B. Makeyev
Published: (2022-10-01)

Content of Short-Lived Radionuclides (<sup>95</sup>Zr, <sup>95</sup>Nb, <sup>103</sup>Ru, and <sup>106</sup>Ru) in Fish
by: Nataliia E. Zarubina, et al.
Published: (2025-07-01)

An Innovative Approach with [<sup>68</sup>Ga]Ga-PSMA PET/CT: The Relationship Between PRIMARY Scores and Clinical and Histopathological Findings
by: Gozde Mutevelizade, et al.
Published: (2025-07-01)

Content of Short-Lived Radionuclides (<sup>54</sup>Mn, <sup>60</sup>Co, and <sup>65</sup>Zn) in Fish
by: Nataliia E. Zarubina, et al.
Published: (2025-02-01)

Hematological toxicity of [225Ac]Ac-PSMA-617 and [177Lu]Lu-PSMA-617 in RM1-PGLS syngeneic mouse model
by: Meryl Maria Vilangattil, et al.
Published: (2025-03-01)

Dynamics of subpopulations of CD15<sup>+</sup>CD66b<sup>+</sup> and CD62L<sup>+</sup>CD63<sup>+</sup> circulating neutrophils in patients with benign neoplasms and progression of kidney cancer
by: I. R. Myagdieva, et al.
Published: (2025-06-01)

Effects of low salinity stress on Na<sup>+</sup>-K<sup>+</sup>-ATPase activities, expression of Na<sup>+</sup>-K<sup>+</sup>-ATPase β-subunit mRNA and microscopical structure in gill filaments of juvenile Mugil cephalus
by: Li Lei, et al.
Published: (2014-03-01)

Radioactive Contaminants in Edible Mushrooms: A Comparative Study of <sup>137</sup>Cs and Natural Radionuclides in Amasya and Tekirdağ, Türkiye
by: Afife Akkaya, et al.
Published: (2025-05-01)

Sensitivity Enhancement of Thermometry in Tb<sup>3+</sup>-Doped KY(CO<sub>3</sub>)<sub>2</sub>:Sm<sup>3+</sup> by Energy Transfer
by: Shijian Sun, et al.
Published: (2025-02-01)

A Comparison Between Calcium and Strontium Transport by the (Ca<sup>2+</sup> + Mg<sup>2+</sup>)ATPase of the Basolateral Plasma Membrane of Renal Proximal Convoluted Tubules
by: José Roberto Meyer-Fernandes, et al.
Published: (2025-04-01)

Activity concentrations of <sup>60</sup> Co, <sup>137</sup>Cs and <sup>241</sup>Am in sieved soil and soil inclusions from the «Taiga» peaceful nuclear explosions site
by: V. P. Ramzaev, et al.
Published: (2024-10-01)

Theranostic Potential of the iPSMA-Bombesin Radioligand in Patients with Metastatic Prostate Cancer: A Pilot Study
by: Sofía González-Rueda, et al.
Published: (2024-10-01)

A comparative study of of T regulatory cells numbers (CD4<sup>+</sup>CD25<sup>high</sup>FoxP3<sup>+</sup>CD127<sup>low</sup>) in patients under 1 year of age with cataract, glaucoma, and retinopathy of prematurity (review of the own studies)
by: L. M. Balashova, et al.
Published: (2025-01-01)

Flow-Dependent Modulation of Endothelial Ca<sup>2+</sup> Dynamics by Small Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channels in Mouse Carotid Arteries
by: Mark S. Taylor, et al.
Published: (2024-12-01)

Determination of Trace <sup>55</sup>Fe and <sup>63</sup>Ni in Steel Samples via Liquid Scintillation Counting
by: Giada Gandolfo, et al.
Published: (2025-07-01)

PET/CT con hallazgo incidental de captación de 18F-PSMA en paciente con COVID-19
by: Jhonatan Gómez-Domínguez, et al.
Published: (2025-01-01)

Foraminifers and stable isotopes (О<sup>16</sup>/О<sup>18</sup> and C<sup>12</sup>/С<sup>13</sup>) of their shells at methane seepages on eastern slope of Sakhalin Island (Okhotsk Sea)
by: Sergey P. Pletnev, et al.
Published: (2014-09-01)

Creating an Innovative Approach to Engagement, Connectivity, and Problem-Solving in Higher Education Institutions Using LEGO<sup>®</sup> Serious Play<sup>®</sup>
by: Cecilia Medupin, et al.
Published: (2025-05-01)

<sup>87</sup>Sr/<sup>86</sup>Sr ISOTOPE RATIOS IN THE RIVER WATERS OF THE SOUTHERN URALS
by: D. V. Kiseleva, et al.
Published: (2022-06-01)

Root Response to K<sup>+</sup>-Deprivation in Wheat (<i>Triticum aestivum</i> L.): Coordinated Roles of HAK Transporters, AKT2 and SKOR K<sup>+</sup>-Channels, and Phytohormone Regulation
by: Yuan Huang, et al.
Published: (2025-05-01)

Influence of radioactive isotopes <sup>90</sup>Sr, <sup>137</sup>Cs, <sup>210</sup>Pb on environmental objects and their relationship with bovine leukemia in ecosystems of the Republic of Dagestan
by: A. R. Mustafayev, et al.
Published: (2022-01-01)

Hydrogeochemical zoning of uranium isotopes (<sup>234</sup>U/ <sup>238</sup>U) in the Southern Siberian paleocontinent: the role of the South Baikal reservoir in the groundwater formation
by: S. V. Rasskazov, et al.
Published: (2020-09-01)

[225Ac]Ac-PSMA-617 production method: development of an efficient and reproducible radiolabelling process for establish a clinical routine production
by: Michela Aurilio, et al.
Published: (2025-05-01)

A Retrospective Assessment of Neuropathic Pain in Response to Intraneural Facilitation<sup>®</sup> Therapy and Neurovascular Index-Guided Food Elimination
by: Mark Bussell, et al.
Published: (2025-03-01)

Recent Advances on the Positively-Charged Nanofiltration Membranes for Mg<sup>2+</sup>/Li<sup>+</sup> Separation Through Interfacial Polymerization
by: Xinyu Zeng, et al.
Published: (2025-06-01)

Study on the Influence of Ca<sup>2＋ </sup>and Mg<sup>2＋</sup> on the Properties of Zinc-Manganese Phosphate Coatings
by: LU Guojian, SUN Shenglong, ZHU Xiaohui, WANG Aixiang
Published: (2025-05-01)

Leaching Characteristics of Exogenous Cl<sup>−</sup> in Rain-Fed Potato Fields and Residual Estimation Model Validation
by: Jiaqi Li, et al.
Published: (2025-07-01)

Decreased CCL5 expression in endometrial stromal cells induces deficient CCR5<sup>+</sup>CD4<sup>+</sup> T cells in endometriosis
by: Li Yue, et al.
Published: (2025-01-01)

Research advance of N <sup>6</sup>-methyladenosine (m<sup>6</sup>A) in insect
by: ZHAO Shudi, et al.
Published: (2021-06-01)