Expression pattern of lncRNA H19 in oral squamous cell carcinoma tissues in comparison to normal tissues. A systematic review
Background: With a high mortality rate, oral squamous cell carcinoma (OSCC), accounts for more than 90 % of all mouth cancers and is a major global health concern. The necessity for trustworthy biomarkers is highlighted by the fact that early diagnosis and prognosis are still difficult despite advan...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906025000081 |
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| author | Ramya Sekar Selvaraj Jayaraman Saranya Varadarajan Thodur Madapusi Balaji Vishnupriya Veeraraghavan Prabhu Shankar Dayasankar Dharshini Devi J |
| author_facet | Ramya Sekar Selvaraj Jayaraman Saranya Varadarajan Thodur Madapusi Balaji Vishnupriya Veeraraghavan Prabhu Shankar Dayasankar Dharshini Devi J |
| author_sort | Ramya Sekar |
| collection | DOAJ |
| description | Background: With a high mortality rate, oral squamous cell carcinoma (OSCC), accounts for more than 90 % of all mouth cancers and is a major global health concern. The necessity for trustworthy biomarkers is highlighted by the fact that early diagnosis and prognosis are still difficult despite advancements. A key factor in cancer biology, the long non-coding RNA H19 was first discovered for its function in embryogenesis. H19, reactivated in cancers, interacts with microRNAs and signaling pathways such as p53 and PI3K/AKT to affect tumor growth, invasion, and metastasis. Nevertheless, its expression patterns in OSCC in contrast to healthy tissues remain unclear. The evidence currently available about H19's expression in OSCC is assessed in this review. Methods: The keywords H19 or lncRNA H19 or long non-coding RNA H19″ AND “oral cancer or oral squamous cell carcinoma or tongue squamous cell carcinoma or OSCC” were used to search databases such as PubMed, Scopus, and Clinical Key on 9th December 2024. In addition, the authors manually scanned the reference lists of the included studies or relevant reviews identified through the search to ensure literature saturation. Following the exclusion of duplicates and irrelevant articles, full-text screening of the remaining articles was done to select the articles based on inclusion and exclusion criteria. The Risk of Bias in the included studies was evaluated using the Newcastle Ottawa scale (NOS). Results: Of 95 articles obtained (55 from PubMed, 19 from Scopus, 20 from Clinical Key, and 1 from cross-reference), 56 duplicates or irrelevant articles were eliminated. Of the 39 articles, only eight were selected after the full-text screening of nine articles based on eligibility criteria. All the articles reported a low risk of bias and all the studies reported a change in the expression pattern of H19 in oral squamous cell carcinoma compared to the control. Conclusion: Despite some variability in the direction of changes in H19 expression, most studies have shown its dysregulation in OSCC tissues, highlighting its significance in the pathogenesis of OSCC. |
| format | Article |
| id | doaj-art-e6230b36f4cf46638d6458db3ff9de89 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-e6230b36f4cf46638d6458db3ff9de892025-02-07T04:48:34ZengElsevierOral Oncology Reports2772-90602025-03-0113100720Expression pattern of lncRNA H19 in oral squamous cell carcinoma tissues in comparison to normal tissues. A systematic reviewRamya Sekar0Selvaraj Jayaraman1Saranya Varadarajan2Thodur Madapusi Balaji3Vishnupriya Veeraraghavan4Prabhu Shankar Dayasankar5Dharshini Devi J6Department of Oral & Maxillofacial Pathology and Oral Microbiology, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, 600095, Tamil Nadu, India; Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600 077, IndiaCentre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600 077, India; Corresponding author.Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600 077, Tamil Nadu, IndiaResearch Tagore Dental College and Hospital, Near Vandalur, Melakkottaiyur Post, Rathinamangalam, Tamil Nadu, 600127, IndiaCentre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600 077, IndiaDepartment of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, 600095, Tamil Nadu, IndiaDepartment of Oral & Maxillofacial Pathology and Oral Microbiology, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, 600095, Tamil Nadu, IndiaBackground: With a high mortality rate, oral squamous cell carcinoma (OSCC), accounts for more than 90 % of all mouth cancers and is a major global health concern. The necessity for trustworthy biomarkers is highlighted by the fact that early diagnosis and prognosis are still difficult despite advancements. A key factor in cancer biology, the long non-coding RNA H19 was first discovered for its function in embryogenesis. H19, reactivated in cancers, interacts with microRNAs and signaling pathways such as p53 and PI3K/AKT to affect tumor growth, invasion, and metastasis. Nevertheless, its expression patterns in OSCC in contrast to healthy tissues remain unclear. The evidence currently available about H19's expression in OSCC is assessed in this review. Methods: The keywords H19 or lncRNA H19 or long non-coding RNA H19″ AND “oral cancer or oral squamous cell carcinoma or tongue squamous cell carcinoma or OSCC” were used to search databases such as PubMed, Scopus, and Clinical Key on 9th December 2024. In addition, the authors manually scanned the reference lists of the included studies or relevant reviews identified through the search to ensure literature saturation. Following the exclusion of duplicates and irrelevant articles, full-text screening of the remaining articles was done to select the articles based on inclusion and exclusion criteria. The Risk of Bias in the included studies was evaluated using the Newcastle Ottawa scale (NOS). Results: Of 95 articles obtained (55 from PubMed, 19 from Scopus, 20 from Clinical Key, and 1 from cross-reference), 56 duplicates or irrelevant articles were eliminated. Of the 39 articles, only eight were selected after the full-text screening of nine articles based on eligibility criteria. All the articles reported a low risk of bias and all the studies reported a change in the expression pattern of H19 in oral squamous cell carcinoma compared to the control. Conclusion: Despite some variability in the direction of changes in H19 expression, most studies have shown its dysregulation in OSCC tissues, highlighting its significance in the pathogenesis of OSCC.http://www.sciencedirect.com/science/article/pii/S2772906025000081OSCCH19LncRNANon-codingRNA |
| spellingShingle | Ramya Sekar Selvaraj Jayaraman Saranya Varadarajan Thodur Madapusi Balaji Vishnupriya Veeraraghavan Prabhu Shankar Dayasankar Dharshini Devi J Expression pattern of lncRNA H19 in oral squamous cell carcinoma tissues in comparison to normal tissues. A systematic review Oral Oncology Reports OSCC H19 LncRNA Non-coding RNA |
| title | Expression pattern of lncRNA H19 in oral squamous cell carcinoma tissues in comparison to normal tissues. A systematic review |
| title_full | Expression pattern of lncRNA H19 in oral squamous cell carcinoma tissues in comparison to normal tissues. A systematic review |
| title_fullStr | Expression pattern of lncRNA H19 in oral squamous cell carcinoma tissues in comparison to normal tissues. A systematic review |
| title_full_unstemmed | Expression pattern of lncRNA H19 in oral squamous cell carcinoma tissues in comparison to normal tissues. A systematic review |
| title_short | Expression pattern of lncRNA H19 in oral squamous cell carcinoma tissues in comparison to normal tissues. A systematic review |
| title_sort | expression pattern of lncrna h19 in oral squamous cell carcinoma tissues in comparison to normal tissues a systematic review |
| topic | OSCC H19 LncRNA Non-coding RNA |
| url | http://www.sciencedirect.com/science/article/pii/S2772906025000081 |
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