A Novel Risk Score for Type 2 Diabetes Containing Sleep Duration: A 7-Year Prospective Cohort Study among Chinese Participants
Background. Sleep duration is associated with type 2 diabetes (T2D). However, few T2D risk scores include sleep duration. We aimed to develop T2D scores containing sleep duration and to estimate the additive value of sleep duration. Methods. We used data from 43,404 adults without T2D in the Beijing...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/2969105 |
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| author | Xiangtong Liu Zhiwei Li Jingbo Zhang Shuo Chen Lixin Tao Yanxia Luo Xiaolin Xu Jason Peter Fine Xia Li Xiuhua Guo |
| author_facet | Xiangtong Liu Zhiwei Li Jingbo Zhang Shuo Chen Lixin Tao Yanxia Luo Xiaolin Xu Jason Peter Fine Xia Li Xiuhua Guo |
| author_sort | Xiangtong Liu |
| collection | DOAJ |
| description | Background. Sleep duration is associated with type 2 diabetes (T2D). However, few T2D risk scores include sleep duration. We aimed to develop T2D scores containing sleep duration and to estimate the additive value of sleep duration. Methods. We used data from 43,404 adults without T2D in the Beijing Health Management Cohort study. The participants were surveyed approximately every 2 years from 2007/2008 to 2014/2015. Sleep duration was calculated from the self-reported usual time of going to bed and waking up at baseline. Logistic regression was employed to construct the risk scores. Integrated discrimination improvement (IDI) and net reclassification improvement (NRI) were used to estimate the additional value of sleep duration. Results. After a median follow-up of 6.8 years, we recorded 2623 (6.04%) new cases of T2D. Shorter (both 6-8 h/night and <6 h/night) sleep durations were associated with an increased risk of T2D (odds ratio OR=1.43, 95% confidence interval CI=1.30-1.59; OR=1.98, 95%CI=1.63-2.41, respectively) compared with a sleep duration of >8 h/night in the adjusted model. Seven variables, including age, education, waist-hip ratio, body mass index, parental history of diabetes, fasting plasma glucose, and sleep duration, were selected to form the comprehensive score; the C-index was 0.74 (95% CI: 0.71-0.76) for the test set. The IDI and NRI values for sleep duration were 0.017 (95% CI: 0.012-0.022) and 0.619 (95% CI: 0.518-0.695), respectively, suggesting good improvement in the predictive ability of the comprehensive nomogram. The decision curves showed that women and individuals older than 50 had more net benefit. Conclusions. The performance of T2D risk scores developed in the study could be improved by containing the shorter estimated sleep duration, particularly in women and individuals older than 50. |
| format | Article |
| id | doaj-art-e6219d56d4ff4f73a2d9633f0727b2c7 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-e6219d56d4ff4f73a2d9633f0727b2c72025-08-20T02:21:02ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/29691052969105A Novel Risk Score for Type 2 Diabetes Containing Sleep Duration: A 7-Year Prospective Cohort Study among Chinese ParticipantsXiangtong Liu0Zhiwei Li1Jingbo Zhang2Shuo Chen3Lixin Tao4Yanxia Luo5Xiaolin Xu6Jason Peter Fine7Xia Li8Xiuhua Guo9School of Public Health, Capital Medical University, Beijing 100069, ChinaSchool of Public Health, Capital Medical University, Beijing 100069, ChinaBeijing Physical Examination Center, Beijing 100077, ChinaBeijing Physical Examination Center, Beijing 100077, ChinaSchool of Public Health, Capital Medical University, Beijing 100069, ChinaSchool of Public Health, Capital Medical University, Beijing 100069, ChinaThe University of Queensland, Brisbane, AustraliaUniversity of North Carolina, Chapel Hill 462001, USALa Trobe University, Melbourne, AustraliaSchool of Public Health, Capital Medical University, Beijing 100069, ChinaBackground. Sleep duration is associated with type 2 diabetes (T2D). However, few T2D risk scores include sleep duration. We aimed to develop T2D scores containing sleep duration and to estimate the additive value of sleep duration. Methods. We used data from 43,404 adults without T2D in the Beijing Health Management Cohort study. The participants were surveyed approximately every 2 years from 2007/2008 to 2014/2015. Sleep duration was calculated from the self-reported usual time of going to bed and waking up at baseline. Logistic regression was employed to construct the risk scores. Integrated discrimination improvement (IDI) and net reclassification improvement (NRI) were used to estimate the additional value of sleep duration. Results. After a median follow-up of 6.8 years, we recorded 2623 (6.04%) new cases of T2D. Shorter (both 6-8 h/night and <6 h/night) sleep durations were associated with an increased risk of T2D (odds ratio OR=1.43, 95% confidence interval CI=1.30-1.59; OR=1.98, 95%CI=1.63-2.41, respectively) compared with a sleep duration of >8 h/night in the adjusted model. Seven variables, including age, education, waist-hip ratio, body mass index, parental history of diabetes, fasting plasma glucose, and sleep duration, were selected to form the comprehensive score; the C-index was 0.74 (95% CI: 0.71-0.76) for the test set. The IDI and NRI values for sleep duration were 0.017 (95% CI: 0.012-0.022) and 0.619 (95% CI: 0.518-0.695), respectively, suggesting good improvement in the predictive ability of the comprehensive nomogram. The decision curves showed that women and individuals older than 50 had more net benefit. Conclusions. The performance of T2D risk scores developed in the study could be improved by containing the shorter estimated sleep duration, particularly in women and individuals older than 50.http://dx.doi.org/10.1155/2020/2969105 |
| spellingShingle | Xiangtong Liu Zhiwei Li Jingbo Zhang Shuo Chen Lixin Tao Yanxia Luo Xiaolin Xu Jason Peter Fine Xia Li Xiuhua Guo A Novel Risk Score for Type 2 Diabetes Containing Sleep Duration: A 7-Year Prospective Cohort Study among Chinese Participants Journal of Diabetes Research |
| title | A Novel Risk Score for Type 2 Diabetes Containing Sleep Duration: A 7-Year Prospective Cohort Study among Chinese Participants |
| title_full | A Novel Risk Score for Type 2 Diabetes Containing Sleep Duration: A 7-Year Prospective Cohort Study among Chinese Participants |
| title_fullStr | A Novel Risk Score for Type 2 Diabetes Containing Sleep Duration: A 7-Year Prospective Cohort Study among Chinese Participants |
| title_full_unstemmed | A Novel Risk Score for Type 2 Diabetes Containing Sleep Duration: A 7-Year Prospective Cohort Study among Chinese Participants |
| title_short | A Novel Risk Score for Type 2 Diabetes Containing Sleep Duration: A 7-Year Prospective Cohort Study among Chinese Participants |
| title_sort | novel risk score for type 2 diabetes containing sleep duration a 7 year prospective cohort study among chinese participants |
| url | http://dx.doi.org/10.1155/2020/2969105 |
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