Longitudinal Assessment of Parkinson’s Motor Symptoms and Dopaminergic Dysfunction Patterns Using DaTSCAN
Introduction: Determining Parkinson’s disease (PD) stage and severity are among the factors affecting treatment strategy. Dopamine transporter scan (DaTSCAN) has high efficiency in the diagnosis of PD, while its role in predicting motor function, dyskinesia, and symptoms severity trajectory remains...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Clinical Parkinsonism & Related Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590112525000350 |
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| author | Amir Hossein Najmi Armin Ariaei Mahboobeh Khezri Masoud Noroozi Melika Arab Bafrani Avesta Gheysari Farideh Sabetghadam Mehdi Ahmadi Mohammad Sadeghi Mahsa Mayeli |
| author_facet | Amir Hossein Najmi Armin Ariaei Mahboobeh Khezri Masoud Noroozi Melika Arab Bafrani Avesta Gheysari Farideh Sabetghadam Mehdi Ahmadi Mohammad Sadeghi Mahsa Mayeli |
| author_sort | Amir Hossein Najmi |
| collection | DOAJ |
| description | Introduction: Determining Parkinson’s disease (PD) stage and severity are among the factors affecting treatment strategy. Dopamine transporter scan (DaTSCAN) has high efficiency in the diagnosis of PD, while its role in predicting motor function, dyskinesia, and symptoms severity trajectory remains controversial. This study aimed to evaluate the associations between motor symptoms patterns in PD with DaTscan findings. Methods: A total of 196 patients were included and grouped based on tremor score, postural instability and gait difficulty score, and the presentation of dyskinesia. Multivariate and ordinal logistic regression models were used to investigate the association between two-year follow-up of the PD patients’ motor symptoms assessment scores and DaTSCAN finding patterns. Results: Patients with dyskinesia exhibited significantly lower DaTSCAN uptake across all measured regions, with the most pronounced reductions observed in the right caudate and left putamen (p < 0.001). Additionally, DaTSCAN values were strongly associated with overall disease severity (p < 0.001). A notable positive correlation was found between DaTSCAN uptake and Schwab and England Activities of Daily Living (ADL) scores, whereas significant negative correlations were observed between DaTSCAN measures (including the caudate, putamen, and anterior putamen) and clinical motor scores, such as MDS-UPDRS III, MDS-UPDRS II, and PIGD. In contrast, DaTSCAN parameters did not significantly predict tremor-dominant (TD) scores. Conclusion: Beyond its diagnostic utility, DaTSCAN provides meaningful insights into disease severity and motor dysfunction in PD, with particular relevance to postural instability and gait disturbance. |
| format | Article |
| id | doaj-art-e61cde01b6494eeaa6030bd7bce8a6d0 |
| institution | OA Journals |
| issn | 2590-1125 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Parkinsonism & Related Disorders |
| spelling | doaj-art-e61cde01b6494eeaa6030bd7bce8a6d02025-08-20T02:24:42ZengElsevierClinical Parkinsonism & Related Disorders2590-11252025-01-011210033110.1016/j.prdoa.2025.100331Longitudinal Assessment of Parkinson’s Motor Symptoms and Dopaminergic Dysfunction Patterns Using DaTSCANAmir Hossein Najmi0Armin Ariaei1Mahboobeh Khezri2Masoud Noroozi3Melika Arab Bafrani4Avesta Gheysari5Farideh Sabetghadam6Mehdi Ahmadi7Mohammad Sadeghi8Mahsa Mayeli9School of Medicine, North Khorasan University of Medical Sciences, North Khorasan, IranCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran; Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran; Corresponding author at: Armin Ariaei School of Medicine, Iran University of Medical Sciences, Hemmat Highway, next to Milad Tower, Tehran 1449614535, Iran.School of Medicine, Jundishapur University of Medical Sciences, Khuzestan, IranDepartment of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, IranSchool of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Cell and Molecular Biology and Microbiology, Faculty of Biological Sciences and Technology, University of Isfahan, Isfahan, IranDepartment of Psychology, Faculty of Psychology, Islamic Azad University Najafabad Branch, Isfahan, IranSchool of Medicine, Isfahan University of Medical Sciences, Isfahan, IranSchool of Medicine, Tehran University of Medical Sciences, Tehran, IranSchool of Medicine, Tehran University of Medical Sciences, Tehran, IranIntroduction: Determining Parkinson’s disease (PD) stage and severity are among the factors affecting treatment strategy. Dopamine transporter scan (DaTSCAN) has high efficiency in the diagnosis of PD, while its role in predicting motor function, dyskinesia, and symptoms severity trajectory remains controversial. This study aimed to evaluate the associations between motor symptoms patterns in PD with DaTscan findings. Methods: A total of 196 patients were included and grouped based on tremor score, postural instability and gait difficulty score, and the presentation of dyskinesia. Multivariate and ordinal logistic regression models were used to investigate the association between two-year follow-up of the PD patients’ motor symptoms assessment scores and DaTSCAN finding patterns. Results: Patients with dyskinesia exhibited significantly lower DaTSCAN uptake across all measured regions, with the most pronounced reductions observed in the right caudate and left putamen (p < 0.001). Additionally, DaTSCAN values were strongly associated with overall disease severity (p < 0.001). A notable positive correlation was found between DaTSCAN uptake and Schwab and England Activities of Daily Living (ADL) scores, whereas significant negative correlations were observed between DaTSCAN measures (including the caudate, putamen, and anterior putamen) and clinical motor scores, such as MDS-UPDRS III, MDS-UPDRS II, and PIGD. In contrast, DaTSCAN parameters did not significantly predict tremor-dominant (TD) scores. Conclusion: Beyond its diagnostic utility, DaTSCAN provides meaningful insights into disease severity and motor dysfunction in PD, with particular relevance to postural instability and gait disturbance.http://www.sciencedirect.com/science/article/pii/S2590112525000350DaTSCANParkinson’s diseaseMotor symptomsDyskinesia |
| spellingShingle | Amir Hossein Najmi Armin Ariaei Mahboobeh Khezri Masoud Noroozi Melika Arab Bafrani Avesta Gheysari Farideh Sabetghadam Mehdi Ahmadi Mohammad Sadeghi Mahsa Mayeli Longitudinal Assessment of Parkinson’s Motor Symptoms and Dopaminergic Dysfunction Patterns Using DaTSCAN Clinical Parkinsonism & Related Disorders DaTSCAN Parkinson’s disease Motor symptoms Dyskinesia |
| title | Longitudinal Assessment of Parkinson’s Motor Symptoms and Dopaminergic Dysfunction Patterns Using DaTSCAN |
| title_full | Longitudinal Assessment of Parkinson’s Motor Symptoms and Dopaminergic Dysfunction Patterns Using DaTSCAN |
| title_fullStr | Longitudinal Assessment of Parkinson’s Motor Symptoms and Dopaminergic Dysfunction Patterns Using DaTSCAN |
| title_full_unstemmed | Longitudinal Assessment of Parkinson’s Motor Symptoms and Dopaminergic Dysfunction Patterns Using DaTSCAN |
| title_short | Longitudinal Assessment of Parkinson’s Motor Symptoms and Dopaminergic Dysfunction Patterns Using DaTSCAN |
| title_sort | longitudinal assessment of parkinson s motor symptoms and dopaminergic dysfunction patterns using datscan |
| topic | DaTSCAN Parkinson’s disease Motor symptoms Dyskinesia |
| url | http://www.sciencedirect.com/science/article/pii/S2590112525000350 |
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