Frontal Lobe Atrophy in Depression after Stroke
Background. Frontal lobe atrophy (FLA) is associated with late life depression. However, the role that FLA plays in the development of depression after stroke (DAS) remains unknown. This study thus examined the association between FLA and DAS. Methods. A convenience sample of 705 Chinese patients wi...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2013/424769 |
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| _version_ | 1849467770344833024 |
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| author | W. K. Tang Y. K. Chen J. Y. Lu V. C. T. Mok Winnie C. W. Chu Gabor S. Ungvari K. S. Wong |
| author_facet | W. K. Tang Y. K. Chen J. Y. Lu V. C. T. Mok Winnie C. W. Chu Gabor S. Ungvari K. S. Wong |
| author_sort | W. K. Tang |
| collection | DOAJ |
| description | Background. Frontal lobe atrophy (FLA) is associated with late life depression. However, the role that FLA plays in the development of depression after stroke (DAS) remains unknown. This study thus examined the association between FLA and DAS. Methods. A convenience sample of 705 Chinese patients with acute ischemic stroke admitted to the acute stroke unit of a university-affiliated regional hospital in Hong Kong participated in the study. A psychiatrist administered the Structural Clinical Interview for DSM-IV to all patients and made a diagnosis of DAS three months after the index stroke. Results. Eighty-five (12.1%) patients were diagnosed with DAS. In univariate analysis, the DAS patients were more likely to have severe FLA (14.1% versus 5.6%). Severe FLA remained an independent predictor of DAS in multivariate analysis, with an odds ratio of 2.6 (95% confidence intervals = 1.2–5.9). Conclusions. The results suggest that FLA may play a role in the pathogenesis of DAS, which supports the hypothesis that cumulative vascular burden may be important in predicting DAS. Further investigations are needed to clarify the impact of FLA on the clinical presentation, treatment response, and outcome of DAS in stroke survivors. |
| format | Article |
| id | doaj-art-e6199bbb778948d7be437333f91c77bb |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-e6199bbb778948d7be437333f91c77bb2025-08-20T03:26:04ZengWileyStroke Research and Treatment2090-81052042-00562013-01-01201310.1155/2013/424769424769Frontal Lobe Atrophy in Depression after StrokeW. K. Tang0Y. K. Chen1J. Y. Lu2V. C. T. Mok3Winnie C. W. Chu4Gabor S. Ungvari5K. S. Wong6Department of Psychiatry, Chinese University of Hong Kong, Hong Kong Department of Psychiatry, Chinese University of Hong Kong, Hong Kong Department of Psychiatry, Chinese University of Hong Kong, Hong Kong Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong Department of Imaging & Interventional Radiology, Chinese University of Hong Kong, Hong Kong School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Western Australia, AustraliaDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong Background. Frontal lobe atrophy (FLA) is associated with late life depression. However, the role that FLA plays in the development of depression after stroke (DAS) remains unknown. This study thus examined the association between FLA and DAS. Methods. A convenience sample of 705 Chinese patients with acute ischemic stroke admitted to the acute stroke unit of a university-affiliated regional hospital in Hong Kong participated in the study. A psychiatrist administered the Structural Clinical Interview for DSM-IV to all patients and made a diagnosis of DAS three months after the index stroke. Results. Eighty-five (12.1%) patients were diagnosed with DAS. In univariate analysis, the DAS patients were more likely to have severe FLA (14.1% versus 5.6%). Severe FLA remained an independent predictor of DAS in multivariate analysis, with an odds ratio of 2.6 (95% confidence intervals = 1.2–5.9). Conclusions. The results suggest that FLA may play a role in the pathogenesis of DAS, which supports the hypothesis that cumulative vascular burden may be important in predicting DAS. Further investigations are needed to clarify the impact of FLA on the clinical presentation, treatment response, and outcome of DAS in stroke survivors.http://dx.doi.org/10.1155/2013/424769 |
| spellingShingle | W. K. Tang Y. K. Chen J. Y. Lu V. C. T. Mok Winnie C. W. Chu Gabor S. Ungvari K. S. Wong Frontal Lobe Atrophy in Depression after Stroke Stroke Research and Treatment |
| title | Frontal Lobe Atrophy in Depression after Stroke |
| title_full | Frontal Lobe Atrophy in Depression after Stroke |
| title_fullStr | Frontal Lobe Atrophy in Depression after Stroke |
| title_full_unstemmed | Frontal Lobe Atrophy in Depression after Stroke |
| title_short | Frontal Lobe Atrophy in Depression after Stroke |
| title_sort | frontal lobe atrophy in depression after stroke |
| url | http://dx.doi.org/10.1155/2013/424769 |
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