Simultaneous Determination of Preservatives in Dairy Products by HPLC and Chemometric Analysis

Cheese and yogurt are two kinds of nutritious dairy products that are used worldwide. The major preservatives in dairy products are sodium benzoate, potassium sorbate, and natamycin. The maximum permitted levels for these additives in cheese and yogurt are established according to Iranian national s...

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Main Authors: Fatemeh Zamani Mazdeh, Sima Sasanfar, Anita Chalipour, Elham Pirhadi, Ghazal Yahyapour, Armin Mohammadi, Akram Rostami, Mohsen Amini, Mannan Hajimahmoodi
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:International Journal of Analytical Chemistry
Online Access:http://dx.doi.org/10.1155/2017/3084359
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author Fatemeh Zamani Mazdeh
Sima Sasanfar
Anita Chalipour
Elham Pirhadi
Ghazal Yahyapour
Armin Mohammadi
Akram Rostami
Mohsen Amini
Mannan Hajimahmoodi
author_facet Fatemeh Zamani Mazdeh
Sima Sasanfar
Anita Chalipour
Elham Pirhadi
Ghazal Yahyapour
Armin Mohammadi
Akram Rostami
Mohsen Amini
Mannan Hajimahmoodi
author_sort Fatemeh Zamani Mazdeh
collection DOAJ
description Cheese and yogurt are two kinds of nutritious dairy products that are used worldwide. The major preservatives in dairy products are sodium benzoate, potassium sorbate, and natamycin. The maximum permitted levels for these additives in cheese and yogurt are established according to Iranian national standards. In this study, we developed a method to detect these preservatives in dairy products by reversed phase chromatography with UV detection in 220 nm, simultaneously. This method was performed on C18 column with ammonium acetate buffer (pH=5) and acetonitrile (73 : 27 v/v) as mobile phase. The method was carried out on 195 samples in 5 kinds of commercial cheeses and yogurts. The results demonstrated insufficient separation where limit of detection (LOD) and limit of quantitation (LOQ) ranged from 0.326 to 0.520 mg/kg and 0.989 to 1.575 mg/kg in benzoate and sorbate, respectively. The correlation coefficient of each calibration curve was mostly higher than 0.997. All samples contained sodium benzoate in various ranges. Natamycin and sorbate were detected in a remarkable amount of samples, while, according to Iranian national standard, only sorbate is permitted to be added in processed cheeses as a preservative. In order to control the quality of dairy products, determination of preservatives is necessary.
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institution Kabale University
issn 1687-8760
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language English
publishDate 2017-01-01
publisher Wiley
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series International Journal of Analytical Chemistry
spelling doaj-art-e616e0c1267c4a33a517d342a3bdc4352025-08-20T03:26:04ZengWileyInternational Journal of Analytical Chemistry1687-87601687-87792017-01-01201710.1155/2017/30843593084359Simultaneous Determination of Preservatives in Dairy Products by HPLC and Chemometric AnalysisFatemeh Zamani Mazdeh0Sima Sasanfar1Anita Chalipour2Elham Pirhadi3Ghazal Yahyapour4Armin Mohammadi5Akram Rostami6Mohsen Amini7Mannan Hajimahmoodi8Pharmaceutical Quality Assurance Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDrug and Food Control Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranFood and Drug Administration, Tehran University of Medical Sciences, Tehran, IranFood and Drug Administration, Tehran University of Medical Sciences, Tehran, IranFood and Drug Administration, Tehran University of Medical Sciences, Tehran, IranDrug and Food Control Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDrug and Food Control Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranFood and Drug Administration, Tehran University of Medical Sciences, Tehran, IranPharmaceutical Quality Assurance Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranCheese and yogurt are two kinds of nutritious dairy products that are used worldwide. The major preservatives in dairy products are sodium benzoate, potassium sorbate, and natamycin. The maximum permitted levels for these additives in cheese and yogurt are established according to Iranian national standards. In this study, we developed a method to detect these preservatives in dairy products by reversed phase chromatography with UV detection in 220 nm, simultaneously. This method was performed on C18 column with ammonium acetate buffer (pH=5) and acetonitrile (73 : 27 v/v) as mobile phase. The method was carried out on 195 samples in 5 kinds of commercial cheeses and yogurts. The results demonstrated insufficient separation where limit of detection (LOD) and limit of quantitation (LOQ) ranged from 0.326 to 0.520 mg/kg and 0.989 to 1.575 mg/kg in benzoate and sorbate, respectively. The correlation coefficient of each calibration curve was mostly higher than 0.997. All samples contained sodium benzoate in various ranges. Natamycin and sorbate were detected in a remarkable amount of samples, while, according to Iranian national standard, only sorbate is permitted to be added in processed cheeses as a preservative. In order to control the quality of dairy products, determination of preservatives is necessary.http://dx.doi.org/10.1155/2017/3084359
spellingShingle Fatemeh Zamani Mazdeh
Sima Sasanfar
Anita Chalipour
Elham Pirhadi
Ghazal Yahyapour
Armin Mohammadi
Akram Rostami
Mohsen Amini
Mannan Hajimahmoodi
Simultaneous Determination of Preservatives in Dairy Products by HPLC and Chemometric Analysis
International Journal of Analytical Chemistry
title Simultaneous Determination of Preservatives in Dairy Products by HPLC and Chemometric Analysis
title_full Simultaneous Determination of Preservatives in Dairy Products by HPLC and Chemometric Analysis
title_fullStr Simultaneous Determination of Preservatives in Dairy Products by HPLC and Chemometric Analysis
title_full_unstemmed Simultaneous Determination of Preservatives in Dairy Products by HPLC and Chemometric Analysis
title_short Simultaneous Determination of Preservatives in Dairy Products by HPLC and Chemometric Analysis
title_sort simultaneous determination of preservatives in dairy products by hplc and chemometric analysis
url http://dx.doi.org/10.1155/2017/3084359
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