The association between coffee intake and femoral neck bone mineral density based on the NHANES and Mendelian randomisation study
Femoral neck bone mineral density (FNBMD) is a high risk factor for femoral head fractures, and coffee intake affects bone mineral density, but the effect on FNBMD remains to be explored. First, we conducted an observational study in the National Health and Nutrition Examination Survey and collected...
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Cambridge University Press
2025-01-01
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| Series: | Journal of Nutritional Science |
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| author | Ke Wang Guoxin Huang Ying Liu Beibei Zhang Da Qian Bin Pei |
| author_facet | Ke Wang Guoxin Huang Ying Liu Beibei Zhang Da Qian Bin Pei |
| author_sort | Ke Wang |
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| description | Femoral neck bone mineral density (FNBMD) is a high risk factor for femoral head fractures, and coffee intake affects bone mineral density, but the effect on FNBMD remains to be explored. First, we conducted an observational study in the National Health and Nutrition Examination Survey and collected data on coffee intake, FNBMD, and sixteen covariates. Weight linear regression was used to explore the association of coffee intake with FNBMD. Then, Mendelian randomisation (MR) was used to explore the causal relationship between coffee intake and FNBMD, the exposure factor was coffee intake, and the outcome factor was FNBMD. The inverse variance weighting (IVW) method was used for the analysis, while heterogeneity tests, sensitivity, and pleiotropy analysis were performed. A total of 5 915 people were included in the cross-sectional study, including 3 178 men and 2 737 women. In the completely adjusted model, no coffee was used as a reference. The ORs for the overall population at ‘< 1’, ‘1–<2’, ‘2–<4’, and ‘4+’ (95% CI) were 0.02 (–0.01, 0.04), 0.00 (–0.01, 0.02), –0.01 (–0.02, 0.00), and 0.00 (–0.01, 0.02), respectively. The male and female population showed no statistically significant differences in both univariate and multivariate linear regressions. In the MR study, the IVW results showed an OR (95% CI) of 1.06 (0.88–1.27), a P-value of 0.55, and an overall F-value of 80.31. The heterogeneity, sensitivity analyses, and pleiotropy had no statistical significance. Our study used cross-sectional studies and MR to demonstrate that there is no correlation or causal relationship between coffee intake and FNBMD. |
| format | Article |
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| issn | 2048-6790 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Journal of Nutritional Science |
| spelling | doaj-art-e61611381c4e4b87be54034ab87811e72025-08-20T02:40:13ZengCambridge University PressJournal of Nutritional Science2048-67902025-01-011410.1017/jns.2024.38The association between coffee intake and femoral neck bone mineral density based on the NHANES and Mendelian randomisation studyKe Wang0Guoxin Huang1Ying Liu2Beibei Zhang3Da Qian4Bin Pei5https://orcid.org/0000-0001-6245-3476Department of Burn and Plastic Surgery-Hand Surgery, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People’s Hospital, Changshu, ChinaDepartment of Evidence-Based Medicine Center, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, China School of Public Health and Management, Hubei University of Medicine, Shiyan, ChinaDepartment of Evidence-Based Medicine Center, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, ChinaChronic Disease Department of Xiangyang Center for Disease Control and Prevention, Xiangyang, ChinaDepartment of Burn and Plastic Surgery-Hand Surgery, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People’s Hospital, Changshu, ChinaDepartment of Evidence-Based Medicine Center, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, ChinaFemoral neck bone mineral density (FNBMD) is a high risk factor for femoral head fractures, and coffee intake affects bone mineral density, but the effect on FNBMD remains to be explored. First, we conducted an observational study in the National Health and Nutrition Examination Survey and collected data on coffee intake, FNBMD, and sixteen covariates. Weight linear regression was used to explore the association of coffee intake with FNBMD. Then, Mendelian randomisation (MR) was used to explore the causal relationship between coffee intake and FNBMD, the exposure factor was coffee intake, and the outcome factor was FNBMD. The inverse variance weighting (IVW) method was used for the analysis, while heterogeneity tests, sensitivity, and pleiotropy analysis were performed. A total of 5 915 people were included in the cross-sectional study, including 3 178 men and 2 737 women. In the completely adjusted model, no coffee was used as a reference. The ORs for the overall population at ‘< 1’, ‘1–<2’, ‘2–<4’, and ‘4+’ (95% CI) were 0.02 (–0.01, 0.04), 0.00 (–0.01, 0.02), –0.01 (–0.02, 0.00), and 0.00 (–0.01, 0.02), respectively. The male and female population showed no statistically significant differences in both univariate and multivariate linear regressions. In the MR study, the IVW results showed an OR (95% CI) of 1.06 (0.88–1.27), a P-value of 0.55, and an overall F-value of 80.31. The heterogeneity, sensitivity analyses, and pleiotropy had no statistical significance. Our study used cross-sectional studies and MR to demonstrate that there is no correlation or causal relationship between coffee intake and FNBMD.https://www.cambridge.org/core/product/identifier/S2048679024000387/type/journal_articleCoffeeFemoral neck bone mineral densityMendelian randomisationNational Health and Nutrition Examination Survey |
| spellingShingle | Ke Wang Guoxin Huang Ying Liu Beibei Zhang Da Qian Bin Pei The association between coffee intake and femoral neck bone mineral density based on the NHANES and Mendelian randomisation study Journal of Nutritional Science Coffee Femoral neck bone mineral density Mendelian randomisation National Health and Nutrition Examination Survey |
| title | The association between coffee intake and femoral neck bone mineral density based on the NHANES and Mendelian randomisation study |
| title_full | The association between coffee intake and femoral neck bone mineral density based on the NHANES and Mendelian randomisation study |
| title_fullStr | The association between coffee intake and femoral neck bone mineral density based on the NHANES and Mendelian randomisation study |
| title_full_unstemmed | The association between coffee intake and femoral neck bone mineral density based on the NHANES and Mendelian randomisation study |
| title_short | The association between coffee intake and femoral neck bone mineral density based on the NHANES and Mendelian randomisation study |
| title_sort | association between coffee intake and femoral neck bone mineral density based on the nhanes and mendelian randomisation study |
| topic | Coffee Femoral neck bone mineral density Mendelian randomisation National Health and Nutrition Examination Survey |
| url | https://www.cambridge.org/core/product/identifier/S2048679024000387/type/journal_article |
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