Testosterone and 17β-estradiol regulate hippocampal area CA3 sharp waves in male and female rats

Testosterone and 17β-estradiol regulate hippocampal area CA3 sharp waves in male and female rats

Summary: Sharp wave-ripples (SPW-Rs) are critical to hippocampal function, and the same is true of gonadal steroids, but the interactions are unclear. We find that surgical removal of the gonads greatly reduces SPW rates in both sexes. Ripples are greatly reduced also. Testosterone treatment rescues...

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Bibliographic Details
Main Authors: Patrice Pearce, John J. LaFrancois, Vanessa Skucas, Daniel Friedman, André A. Fenton, Dino Dvorak, Neil J. MacLusky, Helen E. Scharfman
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007235
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