Antibacterial activity of new ciprofloxacin conjugates
Numerous antibiotics are no longer effective against certain germs, rendering it harder to treat illnesses and inflicting unnecessary suffering and death on many individuals. This necessitates the introduction of new antibacterial agents to counteract bacterial antibiotic resistance. In a previous...
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College of Pharmacy / Mustansiriyah University
2024-10-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
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| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1080 |
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| author | Gheith M Alasadi Zaid Al-Obaidi |
| author_facet | Gheith M Alasadi Zaid Al-Obaidi |
| author_sort | Gheith M Alasadi |
| collection | DOAJ |
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Numerous antibiotics are no longer effective against certain germs, rendering it harder to treat illnesses and inflicting unnecessary suffering and death on many individuals. This necessitates the introduction of new antibacterial agents to counteract bacterial antibiotic resistance. In a previous published work,
new ciprofloxacin conjugates were synthesized by amidification and esterification of the ciprofloxacin core structure. The antibacterial activity of these new ciprofloxacin derivatives was evaluated by clinical and laboratory standard instruments. The Laboratory of Public Health/ Branch of Microbiology in Karbala evaluated their collected strains for each species. All compounds exhibited antibacterial properties, where the inhibition zones were measured and the values reported. Bacterial susceptibility to recently produced chemicals tended to be as follows: Pseudomonas aeruginosa is followed by Klebsiella pneumoniae, Proteus mirabilis, and Escherichia coli. The synthesized compounds had stronger antibacterial properties than the ciprofloxacin used as a starting point.
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| format | Article |
| id | doaj-art-e60e60c154af48cc9dfedbbd33d2feec |
| institution | OA Journals |
| issn | 1815-0993 2959-183X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj-art-e60e60c154af48cc9dfedbbd33d2feec2025-08-20T01:53:30ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2024-10-0124410.32947/ajps.v24i4.1080Antibacterial activity of new ciprofloxacin conjugatesGheith M Alasadi0Zaid Al-Obaidi1Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq2Department of Chemistry and Biochemistry, College of Medicine, University of Kerbala, Karbala, Iraq Numerous antibiotics are no longer effective against certain germs, rendering it harder to treat illnesses and inflicting unnecessary suffering and death on many individuals. This necessitates the introduction of new antibacterial agents to counteract bacterial antibiotic resistance. In a previous published work, new ciprofloxacin conjugates were synthesized by amidification and esterification of the ciprofloxacin core structure. The antibacterial activity of these new ciprofloxacin derivatives was evaluated by clinical and laboratory standard instruments. The Laboratory of Public Health/ Branch of Microbiology in Karbala evaluated their collected strains for each species. All compounds exhibited antibacterial properties, where the inhibition zones were measured and the values reported. Bacterial susceptibility to recently produced chemicals tended to be as follows: Pseudomonas aeruginosa is followed by Klebsiella pneumoniae, Proteus mirabilis, and Escherichia coli. The synthesized compounds had stronger antibacterial properties than the ciprofloxacin used as a starting point. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1080CiprofloxacinAntibioticAmidificationEsterificationAntibacterial |
| spellingShingle | Gheith M Alasadi Zaid Al-Obaidi Antibacterial activity of new ciprofloxacin conjugates Al-Mustansiriyah Journal of Pharmaceutical Sciences Ciprofloxacin Antibiotic Amidification Esterification Antibacterial |
| title | Antibacterial activity of new ciprofloxacin conjugates |
| title_full | Antibacterial activity of new ciprofloxacin conjugates |
| title_fullStr | Antibacterial activity of new ciprofloxacin conjugates |
| title_full_unstemmed | Antibacterial activity of new ciprofloxacin conjugates |
| title_short | Antibacterial activity of new ciprofloxacin conjugates |
| title_sort | antibacterial activity of new ciprofloxacin conjugates |
| topic | Ciprofloxacin Antibiotic Amidification Esterification Antibacterial |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1080 |
| work_keys_str_mv | AT gheithmalasadi antibacterialactivityofnewciprofloxacinconjugates AT zaidalobaidi antibacterialactivityofnewciprofloxacinconjugates |