Enhanced prognostic and immunomodulatory effects of novel cuproptosis-related long noncoding RNAs in wilms tumor
ObjectiveThis study aims to develop a model for long non-coding RNA (lncRNA) associated with cuproptosis and assess the efficacy of immunotherapy and chemotherapy in children with Wilms tumor (WT) based on individualized risk scores.MethodsData was obtained from the online database. Cox proportional...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1566551/full |
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| author | Yadong Li Mingjie Li |
| author_facet | Yadong Li Mingjie Li |
| author_sort | Yadong Li |
| collection | DOAJ |
| description | ObjectiveThis study aims to develop a model for long non-coding RNA (lncRNA) associated with cuproptosis and assess the efficacy of immunotherapy and chemotherapy in children with Wilms tumor (WT) based on individualized risk scores.MethodsData was obtained from the online database. Cox proportional hazards analysis and LASSO Cox regression were employed to generate cuproptosis-related lncRNA signatures. Patients were classified into high- and low-risk groups and clinical outcomes were further analysed. Tumor mutation burden and immunoinfiltration were calculated and potential immunotherapy response was evaluated. The sensitivity of immunotherapy and chemotherapy was ultimately analyzed based on individual risk scores associated with cuproptosis.ResultsA eight cuproptosis-related lncRNAs signature was established and high-risk group showed a worse prognosis than the low-risk group. This model showed a good diagnostic performance. Low-risk group displayed an elevated tumor immune dysfunction and was more sensitive to 13 drugs.ConclusionThe current study introduces a novel approach for predicting clinical prognosis and determining the appropriate therapy for patients with WT. |
| format | Article |
| id | doaj-art-e60c4a52b1c64a8890b285a5b29ec07f |
| institution | Kabale University |
| issn | 2296-889X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-e60c4a52b1c64a8890b285a5b29ec07f2025-08-20T03:48:26ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-05-011210.3389/fmolb.2025.15665511566551Enhanced prognostic and immunomodulatory effects of novel cuproptosis-related long noncoding RNAs in wilms tumorYadong Li0Mingjie Li1Department of Clinical Laboratory, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Laboratory Medicine, Fujian Medical University Union Hospital, Fujian Medical University, Fuzhou, Fujian, ChinaObjectiveThis study aims to develop a model for long non-coding RNA (lncRNA) associated with cuproptosis and assess the efficacy of immunotherapy and chemotherapy in children with Wilms tumor (WT) based on individualized risk scores.MethodsData was obtained from the online database. Cox proportional hazards analysis and LASSO Cox regression were employed to generate cuproptosis-related lncRNA signatures. Patients were classified into high- and low-risk groups and clinical outcomes were further analysed. Tumor mutation burden and immunoinfiltration were calculated and potential immunotherapy response was evaluated. The sensitivity of immunotherapy and chemotherapy was ultimately analyzed based on individual risk scores associated with cuproptosis.ResultsA eight cuproptosis-related lncRNAs signature was established and high-risk group showed a worse prognosis than the low-risk group. This model showed a good diagnostic performance. Low-risk group displayed an elevated tumor immune dysfunction and was more sensitive to 13 drugs.ConclusionThe current study introduces a novel approach for predicting clinical prognosis and determining the appropriate therapy for patients with WT.https://www.frontiersin.org/articles/10.3389/fmolb.2025.1566551/fullwilms tumorcuproptosislncRNAprognosisimmunology |
| spellingShingle | Yadong Li Mingjie Li Enhanced prognostic and immunomodulatory effects of novel cuproptosis-related long noncoding RNAs in wilms tumor Frontiers in Molecular Biosciences wilms tumor cuproptosis lncRNA prognosis immunology |
| title | Enhanced prognostic and immunomodulatory effects of novel cuproptosis-related long noncoding RNAs in wilms tumor |
| title_full | Enhanced prognostic and immunomodulatory effects of novel cuproptosis-related long noncoding RNAs in wilms tumor |
| title_fullStr | Enhanced prognostic and immunomodulatory effects of novel cuproptosis-related long noncoding RNAs in wilms tumor |
| title_full_unstemmed | Enhanced prognostic and immunomodulatory effects of novel cuproptosis-related long noncoding RNAs in wilms tumor |
| title_short | Enhanced prognostic and immunomodulatory effects of novel cuproptosis-related long noncoding RNAs in wilms tumor |
| title_sort | enhanced prognostic and immunomodulatory effects of novel cuproptosis related long noncoding rnas in wilms tumor |
| topic | wilms tumor cuproptosis lncRNA prognosis immunology |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1566551/full |
| work_keys_str_mv | AT yadongli enhancedprognosticandimmunomodulatoryeffectsofnovelcuproptosisrelatedlongnoncodingrnasinwilmstumor AT mingjieli enhancedprognosticandimmunomodulatoryeffectsofnovelcuproptosisrelatedlongnoncodingrnasinwilmstumor |