Design, Synthesis, and In Vitro Antiplatelet Aggregation Activities of Ferulic Acid Derivatives
In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. The in vitro antiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound 7f had p...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/376527 |
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| author | Peng-Xuan Zhang Hang Lin Cheng Qu Yu-Ping Tang Nian-Guang Li Jun Kai Guanxiong Shang Baoquan Li Li Zhang Hui Yan Pei Liu Jin-Ao Duan |
| author_facet | Peng-Xuan Zhang Hang Lin Cheng Qu Yu-Ping Tang Nian-Guang Li Jun Kai Guanxiong Shang Baoquan Li Li Zhang Hui Yan Pei Liu Jin-Ao Duan |
| author_sort | Peng-Xuan Zhang |
| collection | DOAJ |
| description | In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. The in vitro antiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound 7f had potent antiplatelet aggregation activity with its IC50 27.6 μmol/L, and 7f can be regarded as a novel potent antiplatelet aggregation candidate. |
| format | Article |
| id | doaj-art-e6076347778a4c2fa9247420382b0dd7 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-e6076347778a4c2fa9247420382b0dd72025-08-20T03:26:04ZengWileyJournal of Chemistry2090-90632090-90712015-01-01201510.1155/2015/376527376527Design, Synthesis, and In Vitro Antiplatelet Aggregation Activities of Ferulic Acid DerivativesPeng-Xuan Zhang0Hang Lin1Cheng Qu2Yu-Ping Tang3Nian-Guang Li4Jun Kai5Guanxiong Shang6Baoquan Li7Li Zhang8Hui Yan9Pei Liu10Jin-Ao Duan11Jiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaIn order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. The in vitro antiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound 7f had potent antiplatelet aggregation activity with its IC50 27.6 μmol/L, and 7f can be regarded as a novel potent antiplatelet aggregation candidate.http://dx.doi.org/10.1155/2015/376527 |
| spellingShingle | Peng-Xuan Zhang Hang Lin Cheng Qu Yu-Ping Tang Nian-Guang Li Jun Kai Guanxiong Shang Baoquan Li Li Zhang Hui Yan Pei Liu Jin-Ao Duan Design, Synthesis, and In Vitro Antiplatelet Aggregation Activities of Ferulic Acid Derivatives Journal of Chemistry |
| title | Design, Synthesis, and In Vitro Antiplatelet Aggregation Activities of Ferulic Acid Derivatives |
| title_full | Design, Synthesis, and In Vitro Antiplatelet Aggregation Activities of Ferulic Acid Derivatives |
| title_fullStr | Design, Synthesis, and In Vitro Antiplatelet Aggregation Activities of Ferulic Acid Derivatives |
| title_full_unstemmed | Design, Synthesis, and In Vitro Antiplatelet Aggregation Activities of Ferulic Acid Derivatives |
| title_short | Design, Synthesis, and In Vitro Antiplatelet Aggregation Activities of Ferulic Acid Derivatives |
| title_sort | design synthesis and in vitro antiplatelet aggregation activities of ferulic acid derivatives |
| url | http://dx.doi.org/10.1155/2015/376527 |
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