SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells
Splicing factor 3b subunit 4, a critical component of pre-message RNA splicing complex, has been reported to play an important part in the tumorigenesis. However, the expression pattern and biological role of splicing factor 3b subunit 4 in pancreatic cancer have never been investigated. In this stu...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-03-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317695913 |
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| _version_ | 1849248212054966272 |
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| author | Wentao Zhou Ning Ma Hao Jiang Yefei Rong Yuezhen Deng Yuanyuan Feng Hongxu Zhu Tiantao Kuang Wenhui Lou Dong Xie Dansong Wang |
| author_facet | Wentao Zhou Ning Ma Hao Jiang Yefei Rong Yuezhen Deng Yuanyuan Feng Hongxu Zhu Tiantao Kuang Wenhui Lou Dong Xie Dansong Wang |
| author_sort | Wentao Zhou |
| collection | DOAJ |
| description | Splicing factor 3b subunit 4, a critical component of pre-message RNA splicing complex, has been reported to play an important part in the tumorigenesis. However, the expression pattern and biological role of splicing factor 3b subunit 4 in pancreatic cancer have never been investigated. In this study, we found that both the messenger RNA ( p < 0.001) and protein level of splicing factor 3b subunit 4 were decreased significantly in pancreatic cancer specimens compared with their adjacent normal tissues. Overexpression of splicing factor 3b subunit 4 in pancreatic cancer cells inhibited cell growth and motility in vitro, while suppressing splicing factor 3b subunit 4 expression promoted the proliferation and migration of pancreatic cancer cells. In addition, splicing factor 3b subunit 4 was found to inhibit the activity of signal transducer and activator of transcription 3 signaling via downregulating the phosphorylation of signal transducer and activator of transcription 3 on a tyrosine residue at position 705. Taken together, these findings demonstrated that splicing factor 3b subunit 4 acted as a suppressive role in pancreatic cancer and indicated that restoring the function of splicing factor 3b subunit 4 might be a strategy for cancer therapy. |
| format | Article |
| id | doaj-art-e606117bd642406693a98c35817e773c |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-e606117bd642406693a98c35817e773c2025-08-20T03:57:59ZengSAGE PublishingTumor Biology1423-03802017-03-013910.1177/1010428317695913SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cellsWentao Zhou0Ning Ma1Hao Jiang2Yefei Rong3Yuezhen Deng4Yuanyuan Feng5Hongxu Zhu6Tiantao Kuang7Wenhui Lou8Dong Xie9Dansong Wang10Department of General Surgery, Zhongshan Hospital Affiliated to Fudan University, Shanghai, ChinaLaboratory of Molecular Oncology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai, ChinaEast China University of Science and Technology, Shanghai, ChinaDepartment of General Surgery, Zhongshan Hospital Affiliated to Fudan University, Shanghai, ChinaLaboratory of Molecular Oncology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai, ChinaLaboratory of Molecular Oncology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai, ChinaDepartment of General Surgery, Zhongshan Hospital Affiliated to Fudan University, Shanghai, ChinaDepartment of General Surgery, Zhongshan Hospital Affiliated to Fudan University, Shanghai, ChinaDepartment of General Surgery, Zhongshan Hospital Affiliated to Fudan University, Shanghai, ChinaEast China University of Science and Technology, Shanghai, ChinaDepartment of General Surgery, Zhongshan Hospital Affiliated to Fudan University, Shanghai, ChinaSplicing factor 3b subunit 4, a critical component of pre-message RNA splicing complex, has been reported to play an important part in the tumorigenesis. However, the expression pattern and biological role of splicing factor 3b subunit 4 in pancreatic cancer have never been investigated. In this study, we found that both the messenger RNA ( p < 0.001) and protein level of splicing factor 3b subunit 4 were decreased significantly in pancreatic cancer specimens compared with their adjacent normal tissues. Overexpression of splicing factor 3b subunit 4 in pancreatic cancer cells inhibited cell growth and motility in vitro, while suppressing splicing factor 3b subunit 4 expression promoted the proliferation and migration of pancreatic cancer cells. In addition, splicing factor 3b subunit 4 was found to inhibit the activity of signal transducer and activator of transcription 3 signaling via downregulating the phosphorylation of signal transducer and activator of transcription 3 on a tyrosine residue at position 705. Taken together, these findings demonstrated that splicing factor 3b subunit 4 acted as a suppressive role in pancreatic cancer and indicated that restoring the function of splicing factor 3b subunit 4 might be a strategy for cancer therapy.https://doi.org/10.1177/1010428317695913 |
| spellingShingle | Wentao Zhou Ning Ma Hao Jiang Yefei Rong Yuezhen Deng Yuanyuan Feng Hongxu Zhu Tiantao Kuang Wenhui Lou Dong Xie Dansong Wang SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells Tumor Biology |
| title | SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells |
| title_full | SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells |
| title_fullStr | SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells |
| title_full_unstemmed | SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells |
| title_short | SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells |
| title_sort | sf3b4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells |
| url | https://doi.org/10.1177/1010428317695913 |
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