Discovery and development of a safe and efficient COVID-19 mRNA vaccine, STP2104, using a novel capping library screening method

Discovery and development of a safe and efficient COVID-19 mRNA vaccine, STP2104, using a novel capping library screening method

Messenger RNA (mRNA) vaccines represent a critical avenue for coronavirus disease 2019 (COVID-19) prevention. We developed a COVID-19 mRNA vaccine encoding a codon-optimized full-length ancestral spike (S) protein with a signal peptide, which employs our novel patented co-transcriptional 5′-capping...

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Main Authors: Kanghyun Choi, Joo-Young Lee, Uk-Il Kim, So-Hyun Park, So-Hee Hong, Yoo-Jin Bang, Yun-Ho Hwang, Jong-Eun Lee, Suhyun Park, Soochong Kim, Sunhee Lee, Ye-Jin Yun, Tae-Gi Uhm, Inyoung Lee, Minju Kwon, EunJi Kwon, Suyeon Song, Yongkyoung Kweon, Heejene Kim, Eun-Young Oh, Jae-Yong Kim, Tae-Young Lee, Seo-Yeon Kim, Se-Eun Kim, You-Jin Kim, Seonock Lee, Ruijing Sun, Eun-Joo Lee, Gamin Kim, Hanah Lim, Byungkyun Kim, Jungho Kim, Dokeun Kim, Jae-Hwan Nam, Sang-Myeong Lee, Kyungjin Kim, Joo-Sung Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
mRNA vaccine
COVID-19
SARS-CoV-2
STP2104
5′-cap analogues
capping library screening
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571713/full
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