Photocatalytic degradation of antibiotics and antimicrobial and anticancer activities of two-dimensional ZnO nanosheets
Abstract Active pharmaceutical ingredients have emerged as an environmentally undesirable element because of their widespread exploitation and consequent pollution, which has deleterious effects on living things. In the pursuit of sustainable environmental remediation, biomedical applications, and e...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-05-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-59842-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850162803341524992 |
|---|---|
| author | Abhik Bhuin Saranya Udayakumar Janani Gopalarethinam Debdyuti Mukherjee Koyeli Girigoswami Caroline Ponraj Sujoy Sarkar |
| author_facet | Abhik Bhuin Saranya Udayakumar Janani Gopalarethinam Debdyuti Mukherjee Koyeli Girigoswami Caroline Ponraj Sujoy Sarkar |
| author_sort | Abhik Bhuin |
| collection | DOAJ |
| description | Abstract Active pharmaceutical ingredients have emerged as an environmentally undesirable element because of their widespread exploitation and consequent pollution, which has deleterious effects on living things. In the pursuit of sustainable environmental remediation, biomedical applications, and energy production, there has been a significant focus on two-dimensional materials (2D materials) owing to their unique electrical, optical, and structural properties. Herein, we have synthesized 2D zinc oxide nanosheets (ZnO NSs) using a facile and practicable hydrothermal method and characterized them thoroughly using spectroscopic and microscopic techniques. The 2D nanosheets are used as an efficient photocatalyst for antibiotic (herein, end-user ciprofloxacin (CIP) was used as a model antibiotic) degradation under sunlight. It is observed that ZnO NSs photodegrade ~ 90% of CIP within two hours of sunlight illumination. The molecular mechanism of CIP degradation is proposed based on ex-situ IR analysis. Moreover, the 2D ZNO NSs are used as an antimicrobial agent and exhibit antibacterial qualities against a range of bacterial species, including Escherichia coli, Staphylococcus aureus, and MIC of the bacteria are found to be 5 μg/l and 10 μg/l, respectively. Despite having the biocompatible nature of ZnO, as-synthesized nanosheets have also shown cytotoxicity against two types of cancer cells, i.e. A549 and A375. Thus, ZnO nanosheets showed a nontoxic nature, which can be exploited as promising alternatives in different biomedical applications. |
| format | Article |
| id | doaj-art-e6025c9a51514cc991b810985458f286 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-e6025c9a51514cc991b810985458f2862025-08-20T02:22:28ZengNature PortfolioScientific Reports2045-23222024-05-0114111510.1038/s41598-024-59842-6Photocatalytic degradation of antibiotics and antimicrobial and anticancer activities of two-dimensional ZnO nanosheetsAbhik Bhuin0Saranya Udayakumar1Janani Gopalarethinam2Debdyuti Mukherjee3Koyeli Girigoswami4Caroline Ponraj5Sujoy Sarkar6Physics Division, School of Advanced Sciences, Vellore Institute of Technology ChennaiMedical Bionanotechnology Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE)Medical Bionanotechnology Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE)Centre for Fuel Cell Technology (CFCT), International Advanced Research Centre for Powder Metallurgy and New Materials (ARCI), IIT-M Research ParkMedical Bionanotechnology Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE)Physics Division, School of Advanced Sciences, Vellore Institute of Technology ChennaiChemistry Division, School of Advanced Sciences, Vellore Institute of Technology ChennaiAbstract Active pharmaceutical ingredients have emerged as an environmentally undesirable element because of their widespread exploitation and consequent pollution, which has deleterious effects on living things. In the pursuit of sustainable environmental remediation, biomedical applications, and energy production, there has been a significant focus on two-dimensional materials (2D materials) owing to their unique electrical, optical, and structural properties. Herein, we have synthesized 2D zinc oxide nanosheets (ZnO NSs) using a facile and practicable hydrothermal method and characterized them thoroughly using spectroscopic and microscopic techniques. The 2D nanosheets are used as an efficient photocatalyst for antibiotic (herein, end-user ciprofloxacin (CIP) was used as a model antibiotic) degradation under sunlight. It is observed that ZnO NSs photodegrade ~ 90% of CIP within two hours of sunlight illumination. The molecular mechanism of CIP degradation is proposed based on ex-situ IR analysis. Moreover, the 2D ZNO NSs are used as an antimicrobial agent and exhibit antibacterial qualities against a range of bacterial species, including Escherichia coli, Staphylococcus aureus, and MIC of the bacteria are found to be 5 μg/l and 10 μg/l, respectively. Despite having the biocompatible nature of ZnO, as-synthesized nanosheets have also shown cytotoxicity against two types of cancer cells, i.e. A549 and A375. Thus, ZnO nanosheets showed a nontoxic nature, which can be exploited as promising alternatives in different biomedical applications.https://doi.org/10.1038/s41598-024-59842-6ZnO nanosheetPhotocatalysisAntibiotic degradationAnticancerSunlightAntimicrobial activity |
| spellingShingle | Abhik Bhuin Saranya Udayakumar Janani Gopalarethinam Debdyuti Mukherjee Koyeli Girigoswami Caroline Ponraj Sujoy Sarkar Photocatalytic degradation of antibiotics and antimicrobial and anticancer activities of two-dimensional ZnO nanosheets Scientific Reports ZnO nanosheet Photocatalysis Antibiotic degradation Anticancer Sunlight Antimicrobial activity |
| title | Photocatalytic degradation of antibiotics and antimicrobial and anticancer activities of two-dimensional ZnO nanosheets |
| title_full | Photocatalytic degradation of antibiotics and antimicrobial and anticancer activities of two-dimensional ZnO nanosheets |
| title_fullStr | Photocatalytic degradation of antibiotics and antimicrobial and anticancer activities of two-dimensional ZnO nanosheets |
| title_full_unstemmed | Photocatalytic degradation of antibiotics and antimicrobial and anticancer activities of two-dimensional ZnO nanosheets |
| title_short | Photocatalytic degradation of antibiotics and antimicrobial and anticancer activities of two-dimensional ZnO nanosheets |
| title_sort | photocatalytic degradation of antibiotics and antimicrobial and anticancer activities of two dimensional zno nanosheets |
| topic | ZnO nanosheet Photocatalysis Antibiotic degradation Anticancer Sunlight Antimicrobial activity |
| url | https://doi.org/10.1038/s41598-024-59842-6 |
| work_keys_str_mv | AT abhikbhuin photocatalyticdegradationofantibioticsandantimicrobialandanticanceractivitiesoftwodimensionalznonanosheets AT saranyaudayakumar photocatalyticdegradationofantibioticsandantimicrobialandanticanceractivitiesoftwodimensionalznonanosheets AT jananigopalarethinam photocatalyticdegradationofantibioticsandantimicrobialandanticanceractivitiesoftwodimensionalznonanosheets AT debdyutimukherjee photocatalyticdegradationofantibioticsandantimicrobialandanticanceractivitiesoftwodimensionalznonanosheets AT koyeligirigoswami photocatalyticdegradationofantibioticsandantimicrobialandanticanceractivitiesoftwodimensionalznonanosheets AT carolineponraj photocatalyticdegradationofantibioticsandantimicrobialandanticanceractivitiesoftwodimensionalznonanosheets AT sujoysarkar photocatalyticdegradationofantibioticsandantimicrobialandanticanceractivitiesoftwodimensionalznonanosheets |