Platelet spleen tyrosine kinase is a key regulator of anti-PF4 antibody–induced immunothrombosis

Platelet spleen tyrosine kinase is a key regulator of anti-PF4 antibody–induced immunothrombosis

Abstract: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but serious prothrombotic adverse event after vaccination with adenovector-based COVID-19 vaccines. Laboratory findings indicate that anti–platelet factor 4 (PF4) immunoglobulin G antibodies are the causing factor for the...

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Main Authors: Jan Zlamal, Vera M. Ripoll, Christine S.M. Lee, Filip Toma, Karina Althaus, Flavianna Rigoni, Andreas Witzemann, Shane Whittaker, David Capraro, Günalp Uzun, Tamam Bakchoul, Vivien M. Chen
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952924007377
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