Integrative Spatial Proteomics and Single-Cell RNA Sequencing Unveil Molecular Complexity in Rheumatoid Arthritis for Novel Therapeutic Targeting

Integrative Spatial Proteomics and Single-Cell RNA Sequencing Unveil Molecular Complexity in Rheumatoid Arthritis for Novel Therapeutic Targeting

Understanding the heterogeneity of Rheumatoid Arthritis (RA) and identifying therapeutic targets remain challenging using traditional bulk transcriptomics alone, as it lacks the spatial and protein-level resolution needed to fully capture disease and tissue complexities. In this study, we applied La...

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Bibliographic Details
Main Authors: Xue Wang, Fei Wang, Archana S. Iyer, Heather Knight, Lori J. Duggan, Yingli Yang, Liang Jin, Baoliang Cui, Yupeng He, Jan Schejbal, Lucy A. Phillips, Bohdan P. Harvey, Sílvia Sisó, Yu Tian
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Proteomes
Subjects:
rheumatoid arthritis
laser capture microdissection
untargeted proteomics
mass spectrometry
multi-omics integration
scRNA-seq
Online Access:https://www.mdpi.com/2227-7382/13/2/17
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