Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation
Considerable shortages in the supply of available organs continue to plague the field of solid organ transplantation. Despite changes in allocation, as well as the utilization of extended criteria and living donors, the number of patients waiting for organs continues to grow at an alarming pace. Xen...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/6413012 |
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| author | Jigesh A. Shah Miguel A. Lanaspa Tatsu Tanabe Hironosuke Watanabe Richard J. Johnson Kazuhiko Yamada |
| author_facet | Jigesh A. Shah Miguel A. Lanaspa Tatsu Tanabe Hironosuke Watanabe Richard J. Johnson Kazuhiko Yamada |
| author_sort | Jigesh A. Shah |
| collection | DOAJ |
| description | Considerable shortages in the supply of available organs continue to plague the field of solid organ transplantation. Despite changes in allocation, as well as the utilization of extended criteria and living donors, the number of patients waiting for organs continues to grow at an alarming pace. Xenotransplantation, cross-species solid organ transplantation, offers one potential solution to this dilemma. Previous extensive research dedicated to this field has allowed for resolution of xenograft failure due to acute rejection, leaving new areas of unresolved challenges as barriers to success in large animal models. Specific to kidney xenotransplantation, recent data seems to indicate that graft compromise can occur due to discrepancies in growth between breeds of donors and significant proteinuria leading to nephrotic syndrome in the recipient. Given these potential limitations, herein, we review potential pathways behind proteinuria, as well as potential causative factors related to growth discrepancies. Control of both of these has the potential to allow xenotransplantation to become clinically applicable in an effort to resolve this organ shortage crisis. |
| format | Article |
| id | doaj-art-e5f35ecdbdb14287ad21532c4476dd84 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e5f35ecdbdb14287ad21532c4476dd842025-08-20T03:26:04ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/64130126413012Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney XenotransplantationJigesh A. Shah0Miguel A. Lanaspa1Tatsu Tanabe2Hironosuke Watanabe3Richard J. Johnson4Kazuhiko Yamada5Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USADivision of Renal Diseases and Hypertension, University of Colorado, Aurora, CO, USAColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USAColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USADivision of Renal Diseases and Hypertension, University of Colorado, Aurora, CO, USAColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USAConsiderable shortages in the supply of available organs continue to plague the field of solid organ transplantation. Despite changes in allocation, as well as the utilization of extended criteria and living donors, the number of patients waiting for organs continues to grow at an alarming pace. Xenotransplantation, cross-species solid organ transplantation, offers one potential solution to this dilemma. Previous extensive research dedicated to this field has allowed for resolution of xenograft failure due to acute rejection, leaving new areas of unresolved challenges as barriers to success in large animal models. Specific to kidney xenotransplantation, recent data seems to indicate that graft compromise can occur due to discrepancies in growth between breeds of donors and significant proteinuria leading to nephrotic syndrome in the recipient. Given these potential limitations, herein, we review potential pathways behind proteinuria, as well as potential causative factors related to growth discrepancies. Control of both of these has the potential to allow xenotransplantation to become clinically applicable in an effort to resolve this organ shortage crisis.http://dx.doi.org/10.1155/2018/6413012 |
| spellingShingle | Jigesh A. Shah Miguel A. Lanaspa Tatsu Tanabe Hironosuke Watanabe Richard J. Johnson Kazuhiko Yamada Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation Journal of Immunology Research |
| title | Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation |
| title_full | Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation |
| title_fullStr | Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation |
| title_full_unstemmed | Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation |
| title_short | Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation |
| title_sort | remaining physiological barriers in porcine kidney xenotransplantation potential pathways behind proteinuria as well as factors related to growth discrepancies following pig to kidney xenotransplantation |
| url | http://dx.doi.org/10.1155/2018/6413012 |
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