Effect of continuous infusion in alleviating pain during male urethral catheterization
Abstract Aims The aim of this study was to explore whether continuous infusion causing lubrication can effectively alleviate pain during male urethral catheterization. Methods This prospective, multicenter, double-blinded study included 190 male patients scheduled for urethral catheterization. Patie...
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BMC
2024-12-01
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| Series: | BMC Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s12871-024-02848-4 |
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| author | Lijun Cao Xin Qi Dan Liu Xincheng Mao Liu Luo Mengjiang Liu Xinyi Wen Chunhong Cui Jia Qi Junmei Xu Yulong Cui |
| author_facet | Lijun Cao Xin Qi Dan Liu Xincheng Mao Liu Luo Mengjiang Liu Xinyi Wen Chunhong Cui Jia Qi Junmei Xu Yulong Cui |
| author_sort | Lijun Cao |
| collection | DOAJ |
| description | Abstract Aims The aim of this study was to explore whether continuous infusion causing lubrication can effectively alleviate pain during male urethral catheterization. Methods This prospective, multicenter, double-blinded study included 190 male patients scheduled for urethral catheterization. Patients were randomly allocated into four groups: Group A: the catheter was lubricated with paraffin; Group B: the catheter was lubricated with compound lidocaine gel; Group C: the pump continuously infusing with sterilized water; Group D: the pump continuously infusing with 2% lidocaine. The primary outcome was the visual analogue scale (VAS) scores. Statistical analysis system (SAS) (version 9.4) was used to perform all the statistical analyses. Significance for all results was set at P < 0.05. Results The VAS of Group D was the lowest (18.90 ± 11.44), followed by the Group C (33.00 ± 11.07), and the VAS of Group A was the highest (53.98 ± 14.76). There were significant differences in VAS in Group D compared to Group A(P < 0.0001), Group B(P < 0.0001) and Group C (P < 0.0001), Group C compared to Group A (P < 0.0001) and Group B(P < 0.0001), Group B compared to Group A (P < 0.0001), indicating that patients treated with lidocaine infusion (Group D) experienced significantly less pain than did those in the other three groups. Conclusions Continuous infusion with sterilized water during catheterization is an efficient method for lubricating the urethral mucosa; furthermore, infusion with 2% lidocaine provides better analgesia as well as lubrication. Trial registration The study protocol was registered in the Chinese Clinical Trial Registry (ChiCTR2300070866) ( https://www.chictr.org.cn/showproj.html?proj=194591 ) on Apr. 25th, 2023. |
| format | Article |
| id | doaj-art-e5f2aff1f9d049309f4f212232d87d13 |
| institution | OA Journals |
| issn | 1471-2253 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj-art-e5f2aff1f9d049309f4f212232d87d132025-08-20T02:31:52ZengBMCBMC Anesthesiology1471-22532024-12-012411810.1186/s12871-024-02848-4Effect of continuous infusion in alleviating pain during male urethral catheterizationLijun Cao0Xin Qi1Dan Liu2Xincheng Mao3Liu Luo4Mengjiang Liu5Xinyi Wen6Chunhong Cui7Jia Qi8Junmei Xu9Yulong Cui10Department of Anesthesiology, The Second Xiangya Hospital, Central South UniversityDepartment of Ophthalmology, The Second Xiangya Hospital, Central South UniversityDepartment of Anesthesiology, The Second Xiangya Hospital, Central South UniversityDepartment of Anesthesiology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South UniversityDepartment of Anesthesiology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South UniversityDepartment of Anesthesiology, The First People’s Hospital of ChenzhouDepartment of Anesthesiology, Wenzhou People’s HospitalDepartment of Otolaryngology, the Affiliated Hospital of Guizhou Medical UniversityDepartment of Anesthesiology, The Second Xiangya Hospital, Central South UniversityDepartment of Anesthesiology, The Second Xiangya Hospital, Central South UniversityDepartment of Anesthesiology, The Second Xiangya Hospital, Central South UniversityAbstract Aims The aim of this study was to explore whether continuous infusion causing lubrication can effectively alleviate pain during male urethral catheterization. Methods This prospective, multicenter, double-blinded study included 190 male patients scheduled for urethral catheterization. Patients were randomly allocated into four groups: Group A: the catheter was lubricated with paraffin; Group B: the catheter was lubricated with compound lidocaine gel; Group C: the pump continuously infusing with sterilized water; Group D: the pump continuously infusing with 2% lidocaine. The primary outcome was the visual analogue scale (VAS) scores. Statistical analysis system (SAS) (version 9.4) was used to perform all the statistical analyses. Significance for all results was set at P < 0.05. Results The VAS of Group D was the lowest (18.90 ± 11.44), followed by the Group C (33.00 ± 11.07), and the VAS of Group A was the highest (53.98 ± 14.76). There were significant differences in VAS in Group D compared to Group A(P < 0.0001), Group B(P < 0.0001) and Group C (P < 0.0001), Group C compared to Group A (P < 0.0001) and Group B(P < 0.0001), Group B compared to Group A (P < 0.0001), indicating that patients treated with lidocaine infusion (Group D) experienced significantly less pain than did those in the other three groups. Conclusions Continuous infusion with sterilized water during catheterization is an efficient method for lubricating the urethral mucosa; furthermore, infusion with 2% lidocaine provides better analgesia as well as lubrication. Trial registration The study protocol was registered in the Chinese Clinical Trial Registry (ChiCTR2300070866) ( https://www.chictr.org.cn/showproj.html?proj=194591 ) on Apr. 25th, 2023.https://doi.org/10.1186/s12871-024-02848-4Continuous infusionMulticenter studyPainUrethral catheterization |
| spellingShingle | Lijun Cao Xin Qi Dan Liu Xincheng Mao Liu Luo Mengjiang Liu Xinyi Wen Chunhong Cui Jia Qi Junmei Xu Yulong Cui Effect of continuous infusion in alleviating pain during male urethral catheterization BMC Anesthesiology Continuous infusion Multicenter study Pain Urethral catheterization |
| title | Effect of continuous infusion in alleviating pain during male urethral catheterization |
| title_full | Effect of continuous infusion in alleviating pain during male urethral catheterization |
| title_fullStr | Effect of continuous infusion in alleviating pain during male urethral catheterization |
| title_full_unstemmed | Effect of continuous infusion in alleviating pain during male urethral catheterization |
| title_short | Effect of continuous infusion in alleviating pain during male urethral catheterization |
| title_sort | effect of continuous infusion in alleviating pain during male urethral catheterization |
| topic | Continuous infusion Multicenter study Pain Urethral catheterization |
| url | https://doi.org/10.1186/s12871-024-02848-4 |
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